Re: Enbrel Site Reaction

[Guest guest]

Dear Rivky,

I, too, got a rash at the injection site after the 5th or so injection.

Tonite will be my 10th shot and I don't get rashes anymore. They do go

away as you said. I was not as shocked by the rash, because someone on

this site alerted me to the probability of its occurrence, so I was

ready. The last shot I took, I got a very light colored rash that

disappeared after a day or two, but at the 5th shot, all the injection

sites developed a circular red rash. I knew that it was going to

happen, so didn't freak. You're reaction is typical, from what I've

learned at this site.

Hope you continue to feel good. I am not sure if Enbrel is working,

although there have been some benefits so far. Keep praying, as I do!

Robin

F4s2many@... wrote:

>

> Hi everyone!

>

> Has anyone else experienced an 'injection site reaction' after they

> administer the Enbrel shot? It happened on my 7th injection...the previous

> shots just left me with black and blue marks. This time I was left with a

> roundish, red rash by the injection site. It stayed for a full 4 days and

> then slowly faded away.

>

> I wonder if this is what they call an 'allergic reaction' to the drug? I sure

> hope not 'cuz I've been seeing GREAT results with the Enbrel and I would hate

> to have to stop using it.

>

> If anyone has had this kind of reaction, please let me know how long it

> lasted for and if it happened on ALL subsequent injections or only that one

> time.

>

> Any bit of info would be most appreciated.

>

> Thanks!

>

> Rivky :-)

>

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[Guest guest]

I guess I am one of the unlucky few who have had an allergic reaction to

Enbrel. My reaction included swelling eyes, a terrible flu feeling, and a

wonderful asthma attack (Difficulty breathing.) All this from just 1/2 dose

by the time the 3rd injection was due it was clear Embrel was not a good

choice for me. BTW I am allergic to many medications.

Ilene

[Guest guest]

> Hi everyone!

>

> Has anyone else experienced an 'injection site reaction' after they

> administer the Enbrel shot? It happened on my 7th injection...the

previous

> shots just left me with black and blue marks. - Rivky

From : My rheumatologist recommends making sure you inject

the Enbrel at a 90 degree angle- otherwise the medication will sit in

your adipose tissue- versus the muscle and you will get a site

reaction. Put it in the muscle good and deep next time and you

should have no trouble!!

[Guest guest]

Dear ,

My rd told me the opposite, to put the needle in at 45 degrees and NOT

in the muscle, but in sub-cu. If I get a bump, I rub it over and over

to spread the med around. Did anyone else get infor to inject into

muscle (I don't know if I have the stomach for that, am just getting

used to sub-cu injections.) Would like to hear about this. Thnx. and

Gillian, I just LOVE your messages!!!!

Robin

Atwood-Stack wrote:

>

>

> > Hi everyone!

> >

> > Has anyone else experienced an 'injection site reaction' after they

> > administer the Enbrel shot? It happened on my 7th injection...the

> previous

> > shots just left me with black and blue marks. - Rivky

>

> >From : My rheumatologist recommends making sure you inject

> the Enbrel at a 90 degree angle- otherwise the medication will sit in

> your adipose tissue- versus the muscle and you will get a site

> reaction. Put it in the muscle good and deep next time and you

> should have no trouble!!

>

>

>

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> ------------------------------------------------------------------------

>

> Please visit our new web page at:

> http://www.wpunj.edu/icip/pa

>

> and attend our weekly chat on Dr Koop at

> 7 PM EST on Monday evenings!!

> Go to the www.Dr.Koop.com website ahead of time and register as a user that

way you can come right in on Monday nights. Hope to see you there

> at the chat!!!

[Guest guest]

I am in my third month on Enbrel, so far my site reactions are much as you

describe. Not sure that anything really works except time. I rotate my shots

from leg to leg then side to side on my stomach. So far that has worked for

me, by the time I get back to " oldest " injection site I have plenty of room

and normally cannot find the exact location of the site. I have also found

out that if you wait for the alcohol to dry on the vial and on your skin, the

injection has a bit less sting. Hope this helps.

Bob in VA

[Guest guest]

In a message dated 2/6/03 11:45:25 AM Central Standard Time, mika93@...

writes:

> after my 4th dose of Enbrel I got an injection site reaction ~~~ I'm

concerned that it may not > go away by the time I need to use that injection

> site area again.~~~

>

This is from Wyeth's own enbrel site; <A

HREF= " www.wyeth.com/content/ShowFile.asp?id=101 " >

www.wyeth.com/content/ShowFile.asp?id=101</A>

" Rotate sites for injection (thigh, abdomen, or upper arm). New injections

should be given at least one inch from an old site and never into areas where

the skin is tender, bruised, red, or hard. "

I read a post on another message board about site reactions and wondered if a

person could possibly divide the dose 1/2 in one injection site and 1/2 in

another to reduce site reaction. There may be reasons, of which I am

unaware, that this would be bad idea such as increased rate of dispersion of

the med so maybe you should contact Wyeth to see if you can get an informed

opinion on the matter. Orin

[Guest guest]

In a message dated 2/6/2003 12:45:09 PM Eastern Standard Time,

mika93@... writes:

> Also, what are

> your recommendations for how to make it go away quickly, like

> favorite lotions or rubbing it or not rubbing or something?

I would put some mild cortisone crean on it and it will probably help

Janet

[Guest guest]

> Have any of you noticed contributing factors to the site reaction,

> like why you get it sometimes and not others? Also, what are

> your recommendations for how to make it go away quickly, like

> favorite lotions or rubbing it or not rubbing or something?

At my rheumatologist appt last week the nurse asked me how it was

going with the injections and I mentioned the site reactions I was

having. She said to try icing down the area before and after the

shot. The next shot I did that and had a far smaller reaction.

(Size of a nickel as opposed to 4 inches diameter!) Not only that

but I literally did not feel a thing when the needle went in. We'll

see how it goes with today's shot.

Kathy

[Guest guest]

I just started using Enbrel. What do you mean by a site reaction.

After I give myself the shot the skin feels like there is a lump in

there. Is that what you mean by a site reaction? Please help.

J

> I am in my third month on Enbrel, so far my site reactions are much

as you

> describe. Not sure that anything really works except time. I

rotate my shots

> from leg to leg then side to side on my stomach. So far that has

worked for

> me, by the time I get back to " oldest " injection site I have plenty

of room

> and normally cannot find the exact location of the site. I have

also found

> out that if you wait for the alcohol to dry on the vial and on your

skin, the

> injection has a bit less sting. Hope this helps.

> Bob in VA

>

>

>

[Guest guest]

My site reactions have been a red, splotchy oval, like 3 or 4

inches by 2 or 3 inches. The red area has been slightly raised. I

think one time there was a small bump or lump at the needled

point. But I've only taken 6 shots so far so I'm a newbie.

I wanted to thank the person who recommended icing the area. I

did this last time and it helped so so so much! Well, I also shot

in my thigh rather than my belly, which also helped. I should

know by now not to try two new things at once cause I can't tell

apart the effect of the ice and using my thigh... but either way it

was a much better experience than before. The site reaction

was very small (a small red patch), barely noticable, and

injecting into the cold, iced area was so easy and painless.

Actually the ice was more painful than the injection! Had to

remind myself that too much icing can be damaging!

I'll report back after a few more times.

And, thanks to the other person for recommending using the

cream, but I've been avoiding cortisones ever since I was 14,

had p, used cortisone creams on recommendation from a

derm., which made the p spread like crazy. Ah well, no

cortisones for me!

> I just started using Enbrel. What do you mean by a site

reaction.

> After I give myself the shot the skin feels like there is a lump in

> there. Is that what you mean by a site reaction? Please help.

>

[Guest guest]

Thanks for advice.

I have insulin needles. I get them every time I get Enbrel. The

pharmacy sends it to me per my request. I never used them so far,

because I was warned that changing the needle might leed to an

infection.

But you are right, I should use insulin needles. Next Monday I will

follow your advice.

Thanks,

> > On a third day after my 4th injections, I developed the site

> > reaction.

> > It started like a rash, and then all the red dots " got together " ,

> and

> > now I have big, almost 2 inch in radius bright red spot. It is

> > painful and itches at the same time.

> >

> > I called 1-888-4Enbrel, and they told me that 37% of patients

have

> > this allergic reaction.

> > I called my doctor, and he told me to skip today's injections,

and

> to

> > see him on Monday.

> >

> > Anyone with similar problem? When will it go away?

> >

> > Thanks,

> >

>

>

>

>

[Guest guest]

In a message dated 3/28/2003 9:03:24 PM Eastern Standard Time,

gynot@... writes:

> . Then once it's mixed, I take that needle out, insert the insulin needle

> (available at any drug store) into the same hole so that any dulling effect

> is less, and draw out the mixture. Then I inject with no pain or

> difficulty. I hope this will work for , and anyone else

> who's experiencing this problem. All the best ...

>

> Skana in Nova Scotia

>

Thanks for the advice. I am going to see if this works for me. I have been

getting an injection site reaction that has been lasting for about 5 days..

I started Enbrel 4 weeks ago and have had a cold, cough and congestion ever

since. I was starting to feel like it was working and taking the edge off my

pain. Now my rheumy said to skip my injection yesterday. Does anyone know

if this is going to set back my improvement much?

Janet

[Guest guest]

Thank you, Kathy F. I am going to call today. The

bigger blotch has grown to a 4in by 2in, and the other

one is spreading also. I need to have them show me

where on the tummy to inject because I'd like to wear

my swimsuit.

I haven't noticed anything else... but I am surprised

that it took so long to have a site reaction.

Thank you again....

Jody

--- Jody son <jodpaulson@...> wrote:

> Hi Everyone,

> I have some questions regarding what I think is a

> site

> reaction. I have only had two injections and used

__________________________________________________

[Guest guest]

Hi Rivky

I occasionally get a reaction and when I first started I had that

problem... a lot.....especially when it was a few injections a week

I would try another location

I don't think it is serious

June

>

> Hi everyone!

>

> Has anyone else experienced an 'injection site reaction' after

they

> administer the Enbrel shot? It happened on my 7th injection...the

previous

> shots just left me with black and blue marks. This time I was

left with a

> roundish, red rash by the injection site. It stayed for a full 4

days and

> then slowly faded away.

>

> I wonder if this is what they call an 'allergic reaction' to the

drug? I sure

> hope not 'cuz I've been seeing GREAT results with the Enbrel and I

would hate

> to have to stop using it.

>

> If anyone has had this kind of reaction, please let me know how

long it

> lasted for and if it happened on ALL subsequent injections or only

that one

> time.

>

> Any bit of info would be most appreciated.

>

> Thanks!

>

> Rivky :-)

>

[Guest guest]

Hi Rivky....

I was away for a few days and am behind on my post reading. I recently brought

up this topic as well as I was experiencing site reactions. My reactions came a

few days after the injection and one got as big as my hand. Then a couple days

later they dissappeared. My nurse told me what I was experiencing was normal

and they will start to lessen most likely. This last time I tried my tummy ( SO

MUCH BETTER THAN THE THIGH, for me) and the reaction was minimal.

I was hoping the same as you.... I have received such relief that I did not want

to hear that I could not take it anymore!!!

Have a happy day.

Jody

June on <Juneon@...> wrote:

Hi Rivky

I occasionally get a reaction and when I first started I had that

problem... a lot.....especially when it was a few injections a week

I would try another location

I don't think it is serious

June

>

> Hi everyone!

>

> Has anyone else experienced an 'injection site reaction' after

they

> administer the Enbrel shot? It happened on my 7th injection...the

previous

> shots just left me with black and blue marks. This time I was

left with a

> roundish, red rash by the injection site. It stayed for a full 4

days and

> then slowly faded away.

>

> I wonder if this is what they call an 'allergic reaction' to the

drug? I sure

> hope not 'cuz I've been seeing GREAT results with the Enbrel and I

would hate

> to have to stop using it.

>

> If anyone has had this kind of reaction, please let me know how

long it

> lasted for and if it happened on ALL subsequent injections or only

that one

> time.

>

> Any bit of info would be most appreciated.

>

> Thanks!

>

> Rivky :-)

>

---------------------------------

Want to be your own boss? Learn how on Small Business.

[Guest guest]

Yep, that's right about when mine kicked in. I used the topical cream like

you're describing. I also took Tagamet during the day and benadryl at night.

It didn't last for me. I think it was only a fierce hive for 3-6 mos. Now I

just get a small red patch, much less of a big deal. Kate F

________________________________

From: ~Kami~ <kamilleon@...>

< >

Sent: Sat, May 8, 2010 7:51:52 AM

Subject: [ ] Enbrel Site Reaction

Thursday I administered my 5th Enbrel shot. I had no problems with shots 1-3 but

with shots 4 and 5, I have had noticeable site reactions. Last weeks was large

but did not itch. This week.... itches like crazy!

Does antone else get these? What do you find effective to stop the itching? I am

going to pick up some benedryl cram later. I am going to take a Zyrtec as well

to see if itcalms it down.

Kami

[Guest guest]

Kami....I will sometimes get a pink itchy area but it goes away after a day

usually. I wouldn't give up my enbrel either. I told a friend who had

a similar problem, to take benadryl a couple of days before the shot and

also the day of. it's helped her alot. I expect to get a pinkish itchy area

and if I don't..that's good. sometimes the area is about 3 inches but

will go away. I had a bad reaction to Humira....it was horrible...but enbrel

is mild compared to that.

Hugs..a

In a message dated 5/10/2010 11:48:38 A.M. Eastern Daylight Time,

kalfoley@... writes:

Hi Kami, my whole body would have to break out in hives before I would

give up Enbrel. That stuff is my crack

Try the creams, icing, benadryl in pms beginning the day before injection

and continuing for a few days after and use Tagamet during the day. It went

away and I have to strain to fins the site now. But at first, it was

really impressive, it was hot to the touch thru my clothes! Kate F

Sent from my iPhone

On May 10, 2010, at 9:36 AM, " ~Kami~ " <kamilleon@...> wrote:

,

So you are still taking it? My doctor mentioned last week that if it

continued, I may have to discontinue this medication.

This morning it is 3 in wide and 2.5 long.... hivelive in appearance. I

think it has gotten bigger overnight!

Kami

[ ] Enbrel Site Reaction

Thursday I administered my 5th Enbrel shot. I had no problems with shots

1-3 but with shots 4 and 5, I have had noticeable site reactions. Last weeks

was large but did not itch. This week.... itches like crazy!

Does antone else get these? What do you find effective to stop the

itching? I am going to pick up some benedryl cram later. I am going to take a

Zyrtec as well to see if itcalms it down.

Kami

[Non-text portions of this message have been removed]

[Non-text portions of this message have been removed]

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of the information provided.

For archives or to change subscription options:

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[Guest guest]

,

So you are still taking it? My doctor mentioned last week that if it continued,

I may have to discontinue this medication.

This morning it is 3 in wide and 2.5 long.... hivelive in appearance. I think it

has gotten bigger overnight!

Kami

[ ] Enbrel Site Reaction

Thursday I administered my 5th Enbrel shot. I had no problems with shots 1-3

but with shots 4 and 5, I have had noticeable site reactions. Last weeks was

large but did not itch. This week.... itches like crazy!

Does antone else get these? What do you find effective to stop the itching? I

am going to pick up some benedryl cram later. I am going to take a Zyrtec as

well to see if itcalms it down.

Kami

[Guest guest]

Hi Kami, my whole body would have to break out in hives before I would give up

Enbrel. That stuff is my crack

Try the creams, icing, benadryl in pms beginning the day before injection and

continuing for a few days after and use Tagamet during the day. It went away and

I have to strain to fins the site now. But at first, it was really impressive,

it was hot to the touch thru my clothes! Kate F

Sent from my iPhone

On May 10, 2010, at 9:36 AM, " ~Kami~ " <kamilleon@...> wrote:

,

So you are still taking it? My doctor mentioned last week that if it continued,

I may have to discontinue this medication.

This morning it is 3 in wide and 2.5 long.... hivelive in appearance. I think it

has gotten bigger overnight!

Kami

[ ] Enbrel Site Reaction

Thursday I administered my 5th Enbrel shot. I had no problems with shots 1-3 but

with shots 4 and 5, I have had noticeable site reactions. Last weeks was large

but did not itch. This week.... itches like crazy!

Does antone else get these? What do you find effective to stop the itching? I am

going to pick up some benedryl cram later. I am going to take a Zyrtec as well

to see if itcalms it down.

Kami

[Guest guest]

I use the self mix 25 mgs 2 times a week. This does not have the

preservative in it that causes the burning when injecting. There is no burn at

all

when I inject. I still get a pinkish itchy site reaction some times but

not all the time and it goes away after a bit.

Hope this helps Kami.

Hugs..a

In a message dated 5/11/2010 6:42:27 A.M. Eastern Daylight Time,

Rheumatoid.Arthritis.Support@... writes:

Kami,

I'm sorry that you're having site reaction problems.

According to the reports of other Enbrel users in our group, site

reactions are less likely if you use the Enbrel formulation which you

mix yourself.

Not an MD

On Sat, May 8, 2010 at 7:51 AM, ~Kami~ <kamilleon@...> wrote:

> Thursday I administered my 5th Enbrel shot. I had no problems with shots

1-3 but with shots 4 and 5, I have had noticeable site reactions. Last

weeks was large but did not itch. This week.... itches like crazy!

>

> Does antone else get these? What do you find effective to stop the

itching? I am going to pick up some benedryl cram later. I am going to take a

Zyrtec as well to see if itcalms it down.

>

>

>

>

> Kami

------------------------------------

This is a private list. Should you wish to forward any mail to

nonsubscribers, you must first obtain the writer's permission.

We are NOT physicians. Information on this list is not to be construed

as medical advice, and we cannot guarantee the accuracy and currency

of the information provided.

For archives or to change subscription options:

! Groups Links

[Guest guest]

Kami,

I'm sorry that you're having site reaction problems.

According to the reports of other Enbrel users in our group, site

reactions are less likely if you use the Enbrel formulation which you

mix yourself.

Not an MD

On Sat, May 8, 2010 at 7:51 AM, ~Kami~ <kamilleon@...> wrote:

> Thursday I administered my 5th Enbrel shot. I had no problems with shots 1-3

but with shots 4 and 5, I have had noticeable site reactions. Last weeks was

large but did not itch. This week.... itches like crazy!

>

> Does antone else get these? What do you find effective to stop the itching? I

am going to pick up some benedryl cram later. I am going to take a Zyrtec as

well to see if itcalms it down.

>

>

>

>

> Kami

[Guest guest]

I also use the self mix Enbrel and don't get a burn when I inject.

Occasionally I get a mild injection site reaction, about like a

mosquito bite that is gone the next day. Usually after I inject, I rub

some Sarna lotion or Gold Bond anti-itch cream on the site.

Sue

On May 11, 2010, at 7:38 AM, rascalsniche@... wrote:

> I use the self mix 25 mgs 2 times a week. This does not have the

> preservative in it that causes the burning when injecting. There is

> no burn at all

> when I inject. I still get a pinkish itchy site reaction some

> times but

> not all the time and it goes away after a bit.