Guest guest Posted September 2, 2010 Report Share Posted September 2, 2010 It isw now FDA approved and manufactered by the name ampyra.   http://www.ampyra.com/Joyce Giolitto ________________________________ To: mscured Sent: Thu, September 2, 2010 2:49:28 PM Subject: 4-aminopyridine  This is a prescription drug made with natural elements and it is a potassium channel blocker. There might be other ways to do it that are more alternative medicine friendly. The reasoning is that potassium prevents neurons from healing. This blocks the channels, not allowing potassium to enter the nerves. I'm not sure that this is true, it might be, but I was under the impression that potassium was good for pwms. This product was experimental a few years ago and I don't know how far it went. The claim is that the people who took it walked better. Has anyone here used it or looked into a substitute that does the same thing? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 2, 2010 Report Share Posted September 2, 2010 , sounds almost like you are talking about " Ampyra " , it was just recently approved by FDA after a long fight for this smaller irish-jewish pharm. I believe there was something or is something that is being compounded called, 4-AP. The new drug has some side effects of course - if you have or had seizures you shouldn't take it nor with kidney issues. But at least death is not listed as a side effect;0) Potassium is actually highly important to have proper information flow in your brain, but also for proper nerve and muscle function; a bit tired today to get into all the neuro biological stuff. But either way, potassium is an electrolyte you absolutely need. The idea of the drug is to keep the potassium with it's information longer in the neurons, so that info cannot escape to soon and get to it's " final destiantion " . And the drug is indeed a first symptomatic drug for MSers to help with walking. Our neuro just tried it on some of his pts. Some have rather good results. To me, well I am not the one who has the brain lesions and the symptoms, it's my man, I am still and likely always will be weary of drugs though. He would like to try this one so, since it doesn't mess with the immunesystem per se and may help with walking. Oh well, lots of detox it is for him then! Hope this helps, Bianca ________________________________ To: mscured Sent: Thu, September 2, 2010 2:49:28 PM Subject: 4-aminopyridine  This is a prescription drug made with natural elements and it is a potassium channel blocker. There might be other ways to do it that are more alternative medicine friendly. The reasoning is that potassium prevents neurons from healing. This blocks the channels, not allowing potassium to enter the nerves. I'm not sure that this is true, it might be, but I was under the impression that potassium was good for pwms. This product was experimental a few years ago and I don't know how far it went. The claim is that the people who took it walked better. Has anyone here used it or looked into a substitute that does the same thing? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 2, 2010 Report Share Posted September 2, 2010 , sounds almost like you are talking about " Ampyra " , it was just recently approved by FDA after a long fight for this smaller irish-jewish pharm. I believe there was something or is something that is being compounded called, 4-AP. The new drug has some side effects of course - if you have or had seizures you shouldn't take it nor with kidney issues. But at least death is not listed as a side effect;0) Potassium is actually highly important to have proper information flow in your brain, but also for proper nerve and muscle function; a bit tired today to get into all the neuro biological stuff. But either way, potassium is an electrolyte you absolutely need. The idea of the drug is to keep the potassium with it's information longer in the neurons, so that info cannot escape to soon and get to it's " final destiantion " . And the drug is indeed a first symptomatic drug for MSers to help with walking. Our neuro just tried it on some of his pts. Some have rather good results. To me, well I am not the one who has the brain lesions and the symptoms, it's my man, I am still and likely always will be weary of drugs though. He would like to try this one so, since it doesn't mess with the immunesystem per se and may help with walking. Oh well, lots of detox it is for him then! Hope this helps, Bianca ________________________________ To: mscured Sent: Thu, September 2, 2010 2:49:28 PM Subject: 4-aminopyridine  This is a prescription drug made with natural elements and it is a potassium channel blocker. There might be other ways to do it that are more alternative medicine friendly. The reasoning is that potassium prevents neurons from healing. This blocks the channels, not allowing potassium to enter the nerves. I'm not sure that this is true, it might be, but I was under the impression that potassium was good for pwms. This product was experimental a few years ago and I don't know how far it went. The claim is that the people who took it walked better. Has anyone here used it or looked into a substitute that does the same thing? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 2, 2010 Report Share Posted September 2, 2010 Thanks Bianca, 4-AP/Ampyra is the drug to whch I am referring. It hadn't been registered yet in some of the sites that I looked into. It was brought to my attention by a man that I know and I wanted some feedback so that I had something to rebut him with! I'm not a drug advocate but I'm trying to keep an open mind. I'm not walking at all, not even standing and if there is a chance that there is something to reverse that, I want to know more about it! Let us know if your man ever uses it and what effects it has on him (good and/or bad). And by the way, one of the active ingredients is tarantula venom! > > , sounds almost like you are talking about " Ampyra " , it was just recently > approved by FDA after a long fight for this smaller irish-jewish pharm. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 2, 2010 Report Share Posted September 2, 2010 I started Ampyra on July 14th, and i'm starting to see some improvement, but nothing drastic. i've heard some people are now climbimg stair's that couldn't before and one pt. now walking that was in wheelchair for 7 year's this came from the dr's office i go to. so here is hoping spider's are good for something! LoL Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 3, 2010 Report Share Posted September 3, 2010 The risk of seizures is very dose dependent. I have been taking 4AP--not Ampyra, for several years. It is also used in higher doses by spinal cord injury patients--they can apparently tolerate a higher dose without seizures than msers. I have read they take up to 60mg/day---Ampyra is just 10mg, 2x/day. I have taken 5mg instant release 4AP from a compounding pharmacy and 10 'extended' release, also compounded. Ampyra is supposed to be a far better and safer slow release delivery system and many who have taken both notice a definite advantage with the Ampyra over the older 4AP. 4AP is, however, way cheaper! I found that after being treated for ccsvi, I could dramatically cut my daily dose from 25mg through the day to just 5mg, once or twice a day. I do still notice a little help with muscle strength from it---my legs weren't helped much by the ccsvi treatment. I think the most important thing with either form of this drug is more is not better! If you can't remember if you took a pill, you wait 12 hours to be safe. I ended up getting a daily pill case just to be certain and safe. > talking about " Ampyra " , it was just recently > > approved by FDA after a long fight for this smaller irish-jewish pharm. > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 3, 2010 Report Share Posted September 3, 2010 The risk of seizures is very dose dependent. I have been taking 4AP--not Ampyra, for several years. It is also used in higher doses by spinal cord injury patients--they can apparently tolerate a higher dose without seizures than msers. I have read they take up to 60mg/day---Ampyra is just 10mg, 2x/day. I have taken 5mg instant release 4AP from a compounding pharmacy and 10 'extended' release, also compounded. Ampyra is supposed to be a far better and safer slow release delivery system and many who have taken both notice a definite advantage with the Ampyra over the older 4AP. 4AP is, however, way cheaper! I found that after being treated for ccsvi, I could dramatically cut my daily dose from 25mg through the day to just 5mg, once or twice a day. I do still notice a little help with muscle strength from it---my legs weren't helped much by the ccsvi treatment. I think the most important thing with either form of this drug is more is not better! If you can't remember if you took a pill, you wait 12 hours to be safe. I ended up getting a daily pill case just to be certain and safe. > talking about " Ampyra " , it was just recently > > approved by FDA after a long fight for this smaller irish-jewish pharm. > > > > > > > > Quote Link to comment Share on other sites More sharing options...
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