Guest guest Posted September 12, 2010 Report Share Posted September 12, 2010 FingolimodFingolimod has also been reported to be a cannabinoid receptorantagonist, a cPLA2inhibitor and a ceramide synthaseinhibitor.rINN, codenamed FTY720) is an immunosuppressivedrug. It is derived from the myriocin(ISP-1) metabolite of the fungus Isaria sinclairii. It is a structural analogueof sphingosineand gets phosphorylatedby sphingosine kinasesin the cell (most importantly sphingosine kinase 2). The molecular biology of phospho-fingolimod is thought to lie in its activity at one of the five sphingosine-1-phosphate receptors, S1PR1. It can sequester lymphocytesin lymph nodes, preventing them from moving to the central nervous system for auto-immune responses in multiple sclerosisand was originally proposed as a anti-rejection medication indicated post-transplantation. It has been reported to stimulate the repair process of glial cells and precursor cells after injury. ( Quote Link to comment Share on other sites More sharing options...
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