REVIEW - The environment, geo-epidemiology, and autoimmune diseases: RA

[Guest guest]

Display Settings:AbstractFormatSummarySummary (text)AbstractAbstract

(text)MEDLINEXMLPMID ListApply

Send to:Choose DestinationFileClipboardCollectionsE-mailOrder

FormatSummary (text)Abstract (text)MEDLINEXMLPMID ListCreate File

1 selected item: 20080387FormatSummarySummary (text)AbstractAbstract

(text)MEDLINEXMLPMID ListE-mailAdditional textE-mail " SPAM " filtering

software notice

Add to Clipboard

Add to CollectionsOrder articles

J Autoimmun. 2010 Jan 15. [Epub ahead of print]

The environment, geo-epidemiology, and autoimmune disease: Rheumatoid arthritis.

Tobón GJ, Youinou P, Saraux A.

EA2216, IFR148, Université de Bretagne Occidentale, Brest, and Service

de Rhumatologie, Centre Hospitalier Universitaire de Brest, Brest,

France.

Rheumatoid arthritis (RA) is a chronic inflammatory joint disease

characterized by a distinctive pattern of bone and joint destruction.

RA patients have an increased risk of death. The incidence and

prevalence of RA vary across populations, statistical methods, and

disease definitions. In North America and Northern Europe, the

incidence of RA is estimated at 20-50 cases per 100,000 population and

the prevalence at 0.5-1.1%. Lower incidences and prevalences have been

reported in Southern Europe, and few data are available for developing

countries. Some studies showed declining incidences and prevalences

after the 1960s. RA is a multifactorial disease that results from

interactions between genetic and environmental factors. The main

genetic factors are HLA-DRB1 and the tyrosine-phosphatase gene PTPN22.

Among environmental factors implicated in the development of RA,

smoking shows the strongest association with RA susceptibility and is

also linked to worse outcomes. The aim of this review is to discuss

the available data on the incidence and prevalence of RA, as well as

the genetic and environmental risk factors associated with RA.

PMID: 20080387

http://www.ncbi.nlm.nih.gov/pubmed/20080387

Not an MD