RESEARCH - Effects of glucosamine-chondroitin-quercetin glucoside on synovial fluid in OA and RA

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Biosci Biotechnol Biochem. 2009 Feb;73(2):288-92. Epub 2009 Feb 7.

Effects of an oral administration of glucosamine-chondroitin-quercetin

glucoside on the synovial fluid properties in patients with

osteoarthritis and rheumatoid arthritis.

Matsuno H, Nakamura H, Katayama K, Hayashi S, Kano S, Yudoh K, Kiso Y.

Matsuno Clinic for Rheumatic Diseases, Toyama, Japan.

The effects of an orally administered combination of a

glucosamine-chondroitin-quercetin glucoside (GCQG) supplement on the

synovial fluid properties of patients with osteoarthritis (OA) and

rheumatoid arthritis (RA) were investigated from the clinical

nutrition view point. In this study, forty-six OA and twenty-two RA

patients were administered with the GCQG supplement orally for 3

months. Several parameters of the knee joints were monitored before

and after supplementation. The OA patients showed a significant

improvement in pain symptoms, daily activities (walking and climbing

up and down stairs), and visual analogue scale, and changes in the

synovial fluid properties with respect to the protein concentration,

molecular size of hyaluronic acid, and chondroitin 6-sulphate

concentration were also observed. However, no such effects were

observed in the RA patients. These results suggest that the GCQG

supplement exerted a special effect on improving the synovial fluid

properties in OA patients.

PMID: 19202302

http://www.ncbi.nlm.nih.gov/pubmed/19202302

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