Enbrel

[Guest guest]

Hello Group,

I clipped this from part of the ArthritisNet Newsletter for anyone

interested...............

November 2, 1998 Enbrel Receives FDA Approval for RA Treatment

Enbrel, the first in a new class of rheumatoid arthritis (RA) drugs known as

biologic response modifiers was given the OK by the FDA today. It is indicated

for the reduction of symptoms of moderate to severe RA in those who have

failed to respond to DMARDS. It can be used alone or in combination with

Methotrexate. It targets tumor necrosis factor, or TNF, an immune system

protein that also causes rheumatoid inflammation. When Enbrel is injected, it

literally sops up excess TNF in patients' blood before the substance can make

its way to joints to do damage.

ENBREL has been studied in more than 1,000 people with RA. At 3 months, Phase

III study results in 234 patients demonstrated that 62 percent of the patients

receiving a 25 mg dose of ENBREL reached the primary endpoint of 20 percent

improvement by ACR criteria -- a composite score of select measurements of RA

symptoms including joint pain, joint swelling, and patient and physician

global assessment -- compared to 23 percent of the patients in the placebo

group. In this study, responses were rapid, often appearing within one to two

weeks after initiation of therapy, and nearly always occurred within 3 months.

At 6 months, the secondary endpoints of this study demonstrated a 69% median

improvement in pain (vs. 2% for placebo), a 71% median improvement in tender

joint counts (vs. 6% for placebo), a 51% median improvement in swollen joint

counts (vs. 2% for placebo), and an 88% median reduction in duration of

morning stiffness (vs. 4% for placebo). Phase III results confirmed earlier

Phase II findings.

Immunex said Enbrel, known chemically as etanercept, will be on pharmacy

shelves within days. Patients require subcutaneous injections of 25mg of the

drug twice weekly, costing about $220 a week.

Additional information about ENBREL, including full prescribing information,

can be found on the company-sponsored web site at (www.Enbrelinfo.com). There

is also a Reimbursement Hotline to help you learn if your insurance is going

to cover Enbrel. That number is 1-800-282-7704.

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

[Guest guest]

Hi Deanna,

WE haven't used enbrel here is an article about it though.I found this web

site to be very informative when trying to find out info.just click on the

blue <A HREF= " http://pharminfo.com/drugpr/enbrel_pr.html " >Enbrel (Etanercept)

Recommended for Approval For Rheumatoid Arthritis</A> or

<A HREF= " http://pharminfo.com/disease/ra/ra-site.html " >Rheumatoid Arthritis

Disease Center</A> hope it helps

[Guest guest]

Dear RA,

My rheumatologist at Columbia told me that it is pretty well common knowledge

among his peers that after twelve weeks - if the Enbrel doesn't work - it

won't ever work. I was on it for several weeks, but I got folliculitis, an

infection of hair follicles all over my body, and gained considerable weight,

so I went off of it and had to take antibiotics for the infection. The

latest news on Enbrel has been scary - half a dozen deaths from infections

and a lot more people with infections of all sorts.

I would personally recommend Arava. It is stronger than Methotrexate- and of

the same class- an anti-metabolite. I need to take Prilosec and Tagamet

twice a day due to the stomach inflammation that I have with it. Several

others I know do the same. You also need to watch your blood pressure -

around week seven mine spiked. Corgard twice a day is keeping it in check

now.

The excellent news is that my sed rate is now 21 - a three year low!

[Guest guest]

Ive been on Zoloft for about 4 months, and I do NOT notice a reduction in

pain. I was on MTX for about 3 months, but I just stopped due to the side

effects. I am about to start Arava as soon as I have the script filled. I

dont have insurance and it costs 231 for 30 pills, and that is at costco

Randi

[Guest guest]

On Wed, 19 May 1999 06:46:23 -0700 (PDT), robert harris

<raharris@...> wrote:

>So the questions -- has anyone been on Enbrel for a

>while? Do you find it helpful? Any side effects pop

>up after having taken it for a long period of time?

>If is has not really worked after three months is

>there any chance it will start working after six

>months

I don't think Enbrel has been around long enough to say what the long

term effects might be.

Steve

http://www.zoomnet.net/~steve

[Guest guest]

Rick,

I am so sorry for your pain. Perhaps you can talk with your dr about the

meds I'm currently taking. Azulfadine, (I understand it is slow acting

so you might try again) 500 mg 3X daily, Voltaren - 100 mg 2X daily,

Methotrexate - 2.5 mg 5tabs 1x weekly, Plaquinil - dosage??? 2X daily.

I also found that as I've mentioned to everyone last week, that I was

feeling depression pretty heavy. My doctor put me on Zoloft and after

checking with a few Family practitioner friends of mine, they mentioned

that it also helps with pain control. Has anyone ever heard of this

before??? I'm here to tell you, it was a miracle and I am so lucky to

have been given it.

I never in my wildest dreams would have thought to try an

anti-depressant. Hope this helps.

Dez

[Guest guest]

OK, depression medication. I guess I'll ring in on

this one as I'm there as well.

I have been on Paxil for more than a year and it has

changed my life. I *never* thought that depression

meds would ever work, so the results surprised me as

much as anyone else.

As for pain -- Paxil and Zoloft are the same kind of

medications: SSRIs (selective serotonin re-uptake

inhibitors). My family-practice MD tells me that

Paxil and Prozac (another SSRI) represent polar

opposites of the drug, and Zoloft fits in the middle.

He suggests that none of them really reduce pain per

se, but that in reducing stress/depression they serve

to ease the conditions which complicate and increase

pain.

I don't think it's any coincidence that many of us who

suffer chronic pain also experience depression.

Whether SSRIs serve to reduce pain as a part of their

chemical properties or through the introduction of

emotional balance is irrelevant to me. The fact is I

have found it much easier to deal with the many joys

of this particular disease because I augment my pain

medication with SSRI anti-depressant, and I'd

encourage

others to explore this option as well.

cheers --

RA

--- Randi66@... wrote:

> From: Randi66@...

>

> Ive been on Zoloft for about 4 months, and I do NOT

> notice a reduction in

> pain. I was on MTX for about 3 months, but I just

> stopped due to the side

> effects. I am about to start Arava as soon as I

> have the script filled. I

> dont have insurance and it costs 231 for 30 pills,

> and that is at costco

>

> Randi

>

>

------------------------------------------------------------------------

> Where do some of the Internet's largest email lists

> reside?

>

> At ONElist - the most scalable and reliable service

> on the Internet.

>

_____________________________________________________________

[Guest guest]

Randi,

Sorry, the Zoloft isn't helping. You might talk with your Rheumy about a

different prescription??? that has similar effects.

Also, FYI, my parents get their prescriptions filled at a local Savon

but they honor the prices of other pharmacys. I understand " Wal-Mart (Im

not sure but I'll check) " sometimes has cheaper prices, so their

pharmacist calls over their to compare BEFORE my parents pick up their

prescription. Often times they save $10 to $25 on individual orders. You

might shop around and compare.

Good Luck.

Dez

[Guest guest]

Dear Dave,

Welcome, and glad to hear from you and of your great progress. It gives hope

to many.

I wondered if you could fill us in on Neurotonin, what it is used for in PA

and what kind of drug it is. I have not used it yet, but I was wondering if

it would help with all the pins and needles and nerve pain that results from

the joint degeneration, and inflammation pressing in on the nerves?

I was also wondering about your appetite on Enbrel. It is becoming fairly

evident that it can really increase appetite. I myself went off it due to a

20 lb weight gain in January. Carbohydrate craving drove me nuts. My sed

rate went down by half, but I figured that a large weight gain would be a

side effect that would be extremely detrimental to me since I am already 5'

10 " and 200 ish. My doctor told me that at the pharmaceutical companies

meeting of NY area physicians from teaching hospitals that it had come up as

a side effect believed to be connected to the anti-tumor necrosis factor in

Enbrel. Seems that if you have a lot of excess TNF- you can get " wasting " -

or lose weight - or in my case maintain my weight easily on a very sedentary

schedule, while still enjoying some treats occassionally. The cool thing is

that the company is considering doing a trial for using Enbrel for anorexics!

[Guest guest]

There may be a few on Enbrel, although the expense makes it prohibitive for

many. In addition, I believe this email list's purpose is to focus on the

treatment of RA via the use of antibiotics as well as study other

" alternative methods " that enhance the ability of antibiotics in doing their

job. Normally these " alternative methods " fall outside the realm of

conventional medicines (methotrexate, plaquenil, Enbrel, Arava,etc). I

think many on the list here are trying things like RA-Spes, different herbal

combinations , herbs to treat " leaky gut " such as slippery elm and olive

leaf extract, as well as diet,exercise,etc.

This does not preclude you, however, from reporting your success with Enbrel

or any other drugs you might decide to try (Plaquenil, for instance). That

is always of interest to those of us who may have such a full blown case

that stronger measures may eventually be necessary (at least from the

viewpoint of the individual).

Am very glad to hear that you are getting some relief!

Mark

rheumatic Enbrel

> Is anyone on Enbrel? I have been taking it for a few months now. I seem

to

> be doing very well on it. I don't appear to have any side effects other

> than very sore throat the day after I have the injection. Then it goes

> away.

>

> JB

>

[Guest guest]

" HOLMES, MARK T. " wrote:

>

> From: MHOLMES@... (HOLMES, MARK T.)

>

> There may be a few on Enbrel, although the expense makes it prohibitive for

> many. In addition, I believe this email list's purpose is to focus on the

> treatment of RA via the use of antibiotics as well as study other

> " alternative methods " that enhance the ability of antibiotics in doing their

> job. Normally these " alternative methods " fall outside the realm of

> conventional medicines (methotrexate, plaquenil, Enbrel, Arava,etc). I

> think many on the list here are trying things like RA-Spes, different herbal

> combinations , herbs to treat " leaky gut " such as slippery elm and olive

> leaf extract, as well as diet,exercise,etc.

>

> This does not preclude you, however, from reporting your success with Enbrel

> or any other drugs you might decide to try (Plaquenil, for instance). That

> is always of interest to those of us who may have such a full blown case

> that stronger measures may eventually be necessary (at least from the

> viewpoint of the individual).

Just $0.02 here about the " severity " comment, not to argue, but to

clarify...

Do understand, please, that many of us using/trying these " alternatives "

have severe crippling disease, including but not limited to loss of bone

mass, loss of entire bone sections, confinement to wheelchairs, etc.

Don't let yourself fall into the assumption that these " alternatives "

are " light weight " answers and the Rx meds such as Plaquenil, et al are

" heavy weights " . A more appropriate interpretation would be that for

this individual that works, and that does (did) not. Perhaps it will

work for you as well.

For example, in my case, I have poly RA in *every* joint in my body,

connective tissue involvement, complications from prescriptive meds, was

in a wheelchair, last year, the joint end and lower third of the outer

bone of my right arm is dissolved leaving me with what in x-rays looks

like a hack saw, and I've been dx'd with full blown RA since 1986

requiring (then) 85mg/d of Prednsione for 3 years to come close to

controlling. This is hardly less than " full blown " . And yet, even with

such severity - " things " such as Mark mentioned above did indeed beat

back this horrid disease and give me back my life.

Yes, please do feel free to write about your experiences, but don't make

the mistake of dismissing alternatives such as herbals and Homeopathy

because someone mistakenly labels them " light weights " . They aren't,

they're just different.

HTH

--

Geoff Crenshaw -----------------------

Captain Cook's Cruise Center ** Usual Disclaimers **

-----------------------

Religion: Man's attempt to discover God

Christianity: God's offer to save humankind

[Guest guest]

my insurance will only cover 80% and we have a cap I would hate to start

some thing than not be able to pay for it :-(

>From: " " <charles_c_s@...>

>Reply- onelist

> onelist

>Subject: [ ] Enbrel

>Date: Fri, 03 Sep 1999 09:50:59 PDT

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>From: " " <charles_c_s@...>

>

>Our doctor views Enbrel as a promising drug without much downsize (i.e., he

>doesn't think there will be significant side effects). But who knows. We

>are using it, but our insurance covers it. If insurance doesn't cover it

>the cost (over $US 1000 a month) could be prohibitive.

>Also, it hasn't seem to done the trick for us (although it's hard to know

>what it's really doing when you're on so many drugs together). But I know

>there has been a number of siginificant success cases. If you're insured

>and they'll cover it, it's worth a try. In the U.S. it's FDA approved for

>JRA, so most insurers would probably cover it with the proper prompting

>from

>the doctor.

>Charlie

>

>

>

>

>________________________________________________________________

>Get FREE voicemail, fax and email at http://voicemail.excite.com

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>---------------------------

[Guest guest]

In a message dated 9/4/99 2:06:48 AM !!!First Boot!!!, shancna@...

writes:

<< my insurance will only cover 80% and we have a cap I would hate to start

some thing than not be able to pay for it :-( >>

Hi again,

Are we discussing Enbrel, I assume? Gee, and I thought I must be the only

one in the world taking this weird medication. I only started it a week ago,

so it hasn't done much yet, but I'm trying to stay hopeful. My doctor

assures me it's the latest miracle cure and it will fix me right up. He also

assured me a few years ago that methotrexate was the miracle cure, and then

cyclosporine, and then cytoxin (three days in the hospital hooked up to an IV

each month and puking my guts out for 48 hours straight after the dose was

Not Fun), and then imuran. Honestly I'm starting to lose faith. But there

isn't much else left to try. :\

Anyhow, what kind of insurance do you have, ? I'm on Vytra, and they

are truly awful about it, but they do cover it if you're loud enough -- my

doctor is relentless in calling them every week, sending nasty letters, and

generally being a hardass until they give in and pay up. I have a $10

copayment for each prescription, which sounds like a lot considering all the

meds I'm taking, but when you remember the Enbrel is around $1000 monthly

it's peanuts.

cheers

Jenni

[Guest guest]

Hi all, Guess what my daughters doctor put on Enbrel on Mon she had a

wonderful week she took another on Fri she is moving around like a

cheerleader now. Binding over touching her toes she has never been able to

do that before. It was almost instant for her by Monday night, most amazing!

It scared me to death when the doctor said he wanted to put her on it but so

far looks like its working. It ought to for $12,000.00a year.

[Guest guest]

I have Fallon it is not such a wonderful HMO it has a lot of caps my

daughter only gets 20 visits to rehab a year that is nothing s meds

are not to bad but I have a 1000 a year cap on that to so who know s well I

hope the Embrel is the one for you it sounds like you have had them all . Do

you currently take pred? well see you

>From: ChaosPearl@...

>Reply- onelist

> onelist

>Subject: Re: [ ] Enbrel

>Date: Fri, 3 Sep 1999 22:18:39 EDT

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>From: ChaosPearl@...

>

>In a message dated 9/4/99 2:06:48 AM !!!First Boot!!!, shancna@...

>writes:

>

><< my insurance will only cover 80% and we have a cap I would hate to start

> some thing than not be able to pay for it :-( >>

>

>Hi again,

>

>Are we discussing Enbrel, I assume? Gee, and I thought I must be the only

>one in the world taking this weird medication. I only started it a week

>ago,

>so it hasn't done much yet, but I'm trying to stay hopeful. My doctor

>assures me it's the latest miracle cure and it will fix me right up. He

>also

>assured me a few years ago that methotrexate was the miracle cure, and then

>cyclosporine, and then cytoxin (three days in the hospital hooked up to an

>IV

>each month and puking my guts out for 48 hours straight after the dose was

>Not Fun), and then imuran. Honestly I'm starting to lose faith. But there

>isn't much else left to try. :\

>

>Anyhow, what kind of insurance do you have, ? I'm on Vytra, and

>they

>are truly awful about it, but they do cover it if you're loud enough -- my

>doctor is relentless in calling them every week, sending nasty letters, and

>generally being a hardass until they give in and pay up. I have a $10

>copayment for each prescription, which sounds like a lot considering all

>the

>meds I'm taking, but when you remember the Enbrel is around $1000 monthly

>it's peanuts.

>

>cheers

>Jenni

>

>---------------------------

[Guest guest]

Elliot was diagnosed with systemic JRA three years ago June. He had systemic

features at that time- high fever, rash ,stiffness/joint pain. Actually

four months prior to this he had high fever for about three weeks with liver

and spleen enlargement. Elliot had several blood workups and the M.D. for

infectious disease concluded at that time that he had Epstien Barr

virus(mono). I believe that was the beginning of the JRA - we never took

new lab tests to see that his results returned to normal. Anyway the more

classic systemic symptoms manifested itself in June. Elliot began steriods in

July and mtx towards the end of August. We haven't seen any rash for

quite some time. When he flares, Elliot presents with fever and a lot of

joint pain/arthritis. We began Enbrel this past February -Elliot wasn't

actually in a flare but we had been trying to taper the steroids and his

labs continued to reflect increasing loss of control. Our doctor told us

that it would probably take three weeks to notice a change and the first labs

showed improvement ESR dropped down to 25 . But after that the ESR kept

rising so we tried doubling the dose about two months ago. We really

haven't seen any change.

Our doctor has a group of patients on Enbrel with only one or two who are

successful cases.- one of which I know is a child with systemic JRA . I

hope those of you who have children on it are having success.

Rena

[Guest guest]

Rena,

Thanks for your input on Elliot's symptoms. We are going to start on

Enbrel at the point when break through pain starts as we lower the steroids.

At least that's the plan. Step by step....

[Guest guest]

Hi Georgina, has had her 3rd shot, we give them here at the house they

showed us how at the hospital. Sent the med. home on Ice. Must stay cold! So

far last Monday then the 2nd on Friday then again this Monday. She is doing

great, getting up early, moving around more. Happier too. No redness at

injection site or hives nothing everything looks good and hopeful right now

no fevers nothing. Infect She says its better to get the shot then to have

the pain smiling again.

[Guest guest]

Hi Gerogina ;

Not so good of a day setbacks today:

My Husband Russ was a Paramedic for 14 years, so he does them the nurse

checked him off on injections, she is on dose number 6 I forgot a week their

and we rotate legs as much as possible, she said getting the shot in the arm

hurt to much and is not willing to try the stomach yet. Woke up today and She

was complaining of pain in both hands and knees with some swelling and point

tenderness and we had to take her to the doctor today because she had night

sweats last night and C/O of a sore throat and sinus hurting today which as

you are aware could be a side affect, and the Doctor said just that; it could

be a side effect or maybe viral he wasn't sure so he placed her on

antibiotics and said to watch her close and if she worsened we would have to

stop shots until she is clear and start again. Her range of motion is still

the same and she is trying real hard to convince us or herself it is better

and the shots are helping. I think if their is improvement it is only a small

percentage. Her Fatigue factor is still high and blood work shows low iron,

high wbc and low hemo while sedrate is still high. Noticing more mood changes

going from happy to grumpy to crying to ready to bite the head off any body

that looked at her; not sure which it could be from the meds, pain or the

sore throat or the combination of all will have to watch her and see.

Have a good weekend and remember to take it one hour at a time, day by day

and at the end of the day when you go to bed and the kids are asleep give

thanks where thanks are due because you survived, defeated it, conquered it

and won now smile and sleep peaceful.

Lin

[Guest guest]

In a message dated 9/11/99 12:03:18 AM Eastern Daylight Time,

LinGS544@... writes:

<< she said getting the shot in the arm

hurt to much and is not willing to try the stomach yet. >>

It hurts worse in the stomach, I've tried that. And it bleeds a bit more. I

do my injections myself, and I need one hand to pinch the skin and the other

to slide the needle in, so upper arms are out ... I rotate both thighs. I

haven't had any injection site flares or redness, for what it's worth. Only

nickle-sized purple bruises. But I'm anemic as well as taking a lot of

prednisone and I bruise when someone looks at me the wrong way, so that's

kinda to be expected. :\

cheers

Jenni

[Guest guest]

I have been away for two weeks,and would also like to hear from anyone who has

had

any experience with enbrel.

> X-Unix-From: jmj@... Wed Aug 25 00:19:07 1999

> X-BadHeader: Wed Aug 25 00:19:07 1999

> X-Sender: jmj@...

> @...

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> Mime-Version: 1.0

> Subject: rheumatic Enbrel

>

> From: jmj@... (Joanne Jacquette)

>

> I am interested to know of any experiences with Enbrel...

>

> Thanks

> Joanne

>

>

>

_____________________________________________________________________

______

/_____/\ Burnett

/____ \\ \ International Partner Sales Manager MEA

/_____\ \\ / Sun Microsystems

/_____/ \/ / / Middle East Africa Region

/_____/ / \//\

\_____\//\ / / P.O. Box 50769

\_____/ / /\ / Dubai/ U.A.E.

\_____/ \\ \ Phone: +971 4 366333

\_____\ \\ Fax: +971 4 366526

\_____\/ Mob: +971 50 6507049

email: .Burnett@...

URL: http://www.sun.com/

_____________________________________________________________________

[Guest guest]

,

Nice day on SUNW yesterday- UP 5

I have been on Enbrel for about 6 months and feel great- No side effects

yet, feeling great!! Energy level is coming back and I'm working out

regularly which I wasn't able to do before- I would highly recommend

it...

Burnett - Sales Manager - Finance Sector - Sun Microsystems Middle

East wrote:

>

> From: Burnett - Sales Manager - Finance Sector - Sun Microsystems Middle

East <.Burnett@...>

>

> I have been away for two weeks,and would also like to hear from anyone who has

had

> any experience with enbrel.

> > X-Unix-From: jmj@... Wed Aug 25 00:19:07 1999

> > X-BadHeader: Wed Aug 25 00:19:07 1999

> > X-Sender: jmj@...

> > @...

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rheumatic-owneronelist

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> > Mime-Version: 1.0

> > Subject: rheumatic Enbrel

> >

> > From: jmj@... (Joanne Jacquette)

> >

> > I am interested to know of any experiences with Enbrel...

> >

> > Thanks

> > Joanne

> >

> >

> >

> _____________________________________________________________________

> ______

> /_____/\ Burnett

> /____ \\ \ International Partner Sales Manager MEA

> /_____\ \\ / Sun Microsystems

> /_____/ \/ / / Middle East Africa Region

> /_____/ / \//\

> \_____\//\ / / P.O. Box 50769

> \_____/ / /\ / Dubai/ U.A.E.

> \_____/ \\ \ Phone: +971 4 366333

> \_____\ \\ Fax: +971 4 366526

> \_____\/ Mob: +971 50 6507049

> email: .Burnett@...

> URL: http://www.sun.com/

> _____________________________________________________________________

>

>

--

Matzelle

Private Client Services

Stanley & Co.

matzelle@...

312-706-4512

[Guest guest]

What is enbrel?

rheumatic Enbrel

> >

> > From: jmj@... (Joanne Jacquette)

> >

> > I am interested to know of any experiences with Enbrel...

> >

> > Thanks

> > Joanne

> >

> >

> >

> _____________________________________________________________________

> ______

> /_____/\ Burnett

> /____ \\ \ International Partner Sales Manager MEA

> /_____\ \\ / Sun Microsystems

> /_____/ \/ / / Middle East Africa Region

> /_____/ / \//\

> \_____\//\ / / P.O. Box 50769

> \_____/ / /\ / Dubai/ U.A.E.

> \_____/ \\ \ Phone: +971 4 366333

> \_____\ \\ Fax: +971 4 366526

> \_____\/ Mob: +971 50 6507049

> email: .Burnett@...

> URL: http://www.sun.com/

> _____________________________________________________________________

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Matzelle

Private Client Services

Stanley & Co.

matzelle@...

312-706-4512

[Guest guest]

,

You might want to check out the newsgroup alt.support.arthritis - you'll

find a number of folks there who are on Enbrel.

Mark

Re: rheumatic Enbrel

I have been away for two weeks,and would also like to hear from anyone who

has had any experience with Enbrel

[Guest guest]

Hi Sahra,

I have Medicaide-if you want to call that insurance- and yes they do

amazingly enough cover the Enbrel. When, if one thinks about it, the Doc

writes the script it doesn`t ask what the medication is for, RA or PA.

As far as I know it was approved for the use in RA but when I took the

script to the Pharmacy the only thing they told me was that it is a

special order. They do not keep it on hand. So I pay my co-pay and that

is it. Sometime, if you have insurance, call your Pharmacy and ask if

Enbrel is coverd by your insurance. It just might be.

So far no luck with the Enbrel and I have been in a terrible flare for 3

weeks now.

Doc keeps saying give it time. If it is going to work I wish it would

hurry up soI can get some relief. It is attacking the Achillies Tendons

and the ligaments in my ankles.

Good luck if you decide to try it .

aunt-blabby