Re: REVIEW - Drug-induced pancreatitis

[Guest guest]

In a message dated 3/29/2011 10:16:49 A.M. Central Daylight Time,

Rheumatoid.Arthritis.Support@... writes:

Drug induced pancreatitis.

Wow, thanks for all the research. A surgeon just came in to see me and

agreed that it's not drug-induced, that it probably is from a gall stone that

passed through the common bile duct.

The treatment plan changes like the weather. Here's the latest.

I will be weaned from the PCA and get onto real food tomorrow and maybe go

home.

I will be able to go to Boston and hope that I don't get a reoccurrence.

My gall bladder will come out right after i get back. I may have to push my

Remicade infusion out.

I'm happy with this decision.

Thanks again for the research,

dd

[Guest guest]

You are so welcome, dd. Thanks for the update.

I hope you are able to attend and enjoy your dancing event.

Good luck,

Not an MD

On Tue, Mar 29, 2011 at 6:29 PM, <dgd301@...> wrote:

> In a message dated 3/29/2011 10:16:49 A.M. Central Daylight Time,

> Rheumatoid.Arthritis.Support@... writes:

>

> Drug  induced pancreatitis.

>

> Wow, thanks for all the research. A surgeon just came in to see me and

> agreed that it's not drug-induced, that it probably is from a gall stone that

> passed through the common bile duct.

>

> The treatment plan changes like the weather. Here's the latest.

>

> I will be weaned from the PCA and get onto real food tomorrow and maybe go

> home.

>

> I will be able to go to Boston and hope that I don't get a  reoccurrence.

> My gall bladder will come out right after i get back. I may have to push my

>  Remicade infusion out.

>

> I'm happy with this decision.

>

> Thanks again for the research,

>

> dd

[Guest guest]

Pancreatitis is a rare side effect of Victoza, a diabetes injectable.

I was sick for over a month. Absolutel awful. I hope to never have it again.

>

> Best Pract Res Clin Gastroenterol. 2010 Apr;24(2):143-55.

>

>

> Drug induced pancreatitis.

>

>

> Nitsche CJ, son N, Lerch MM, Mayerle JV.

> Department of Medicine A, Ernst-Moritz-Arndt-University Greifswald,

> Friedrich-Loeffler-Strasse 23a, Greifswald 17475, Germany.

>

>

> Abstract

>

> 525 different drugs that can, as an adverse reaction, induce acute

> pancreatitis are listed in a WHO database. Compared to other causes

> drugs represent a relatively rare cause of pancreatitis. They should

> be considered as a triggering event in patients with no other

> identifiable cause of the disease, who takes medications that have

> been shown to induce pancreatitis. The prevalence of drug-induced

> pancreatitis is still unclear because most incidences have been

> documented only as isolated case reports. The overall incidence

> probably ranges from between 0.1 and 2% of pancreatitis cases. For

> only very few substances evidence from controlled trials has been

> obtained.

>

> Epidemiologic data suggest the risk of pancreatitis is highest for

> mesalazine (HR 3.5,) azathioprine (HR 2,5) and simvastatine (HR 1,8).

>

> Even when a definite association has been demonstrated it is often

> impossible to determine whether the drug, or the underlying condition

> for which the drug was taken has conferred the risk of pancreatitis

> (e.g. azathioprine and Crohns disease or pentamidine and HIV).

> Knowledge about the underlying pathophysiologic mechanisms as well as

> evidence for a direct causality often remains sparse. For only 31

> drugs a definite causality has been established. The most frequently

> reported are mesalazine (nine cases in total, three cases with

> re-exposure), azathioprine (five cases in total, two cases with

> re-exposure) and simvastatin (one case in total, this one with

> re-exposure). As cause-effect relationship is generally accepted when

> symptoms re-occur upon re-challenge. Available data from case control

> studies suggest that even drugs with solid evidence for an association

> with pancreatitis only rarely cause the disease. Even when

> pancreatitis is induced as an adverse drug event the disease course is

> usually mild or even subclinical.

>

>

> PMID: 20227028

>

> http://www.ncbi.nlm.nih.gov/pubmed/20227028

>

>

>

>

> Not an MD

>