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>

> Amy and Lucy,

> Hello! You can try giving your daughter Benadryl about 45min to one

hour before the MXT. This took away almost all of my symptoms. Before

I took the Bendadyl I felt like I had the stomach flu every week. I

was ready to tell the Dr I had enough and then someone on another

board suggested I try the Benadryl it worked great. I have since

switched the the injectable form and I have no problems.

Take care

from So. Jersey

PSA dx 3/2004 mother to Kate 18 PSA

>

>

>

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Amy & Lucy - Yes I would definately let the rheumy know. Grant

experienced nausea too and I was very hesitant to call the rheumy

but I finally got sick of him feeling so bad and called. The rheumy

took the call very seriously and wanted to try some different

things. Is lucy also taking folic acid? If not that will

definately help the nausea. Grant took 3 mg/day for a while. I

have also heard about the benedryl from the PsA group I'm in. I've

never heard anyone talk about here though until now. I would ask

the rheumy about that. In fact I think I will ask our rheumy too at

our next appt.

Hope you can get the nausea to subside!

& Grant (11, PsA/Uveitis)

>

> Lucy started mtx injections 10 days ago. She has been nauseous

ever since.

> The rheumy called in a prescription for Zofran a week ago. She is

taking it

> all the time and even then she is still experiencing some nausea.

It's so

> frustrating - the mtx is helping her joints but now she feels

miserable from

> the side effects. She doesn't see the rheumy until Feb. 23. I

don't know

> whether to call him or not. I don't even know what the

alternatives are.

>

>

>

> Amy and Lucy, 6 poly

>

>

>

>

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Hi Amy,

Neat info about Benadryl,it's the first I have heard about it and we have been

dealing withArthur and MTX since July 2001.My son got a bit grean in the face

the first and second dose but then did great.No side effects at all from the

shots.His biggest problem was the awful,yellow color.Now several years later and

in medicated remission he was switched to pills.For a long time he was fine,then

the day before his rheumy apointment he anounced that the pills were making him

sick and sometimes he threw up the pills and asked to be put back on the

dreaded,yellow shot.Luckily when they prescribed the syringes they wrote them

for a little,ity bitty short needle,not the 27 gaugue 1/2 " that he used to do

and what is the smallest,mandatory size for his Enbrel.He almost fell to the

floor laughing at the small size of the needle.We have used Emla for years but

sometimes he doesn't want it for the MTX.

As someone mentioned the folic acid its usualy just a 1mg pill every day,some

docs say not the day of the shot.You can increase the amount to I think 5mg a

day but mayby not for someone so young.Dr.Lehman has a book called It's Not Just

Growing Pains and he says the nausea is not coming from the stomache itself.I

know confusing and he doesn't elaborate much.

I hope you can help your little one get the great benefits that MTX has to offer

without the side effects.

Becki and 10 1/2 systemic onset diagnosed at 2 and 2nd round of medicated

remission

________________________________

From: hendricksonhouseful <nuestrasenora@...>

Sent: Tuesday, January 27, 2009 6:59:22 PM

Subject: MTX side effects

Lucy started mtx injections 10 days ago. She has been nauseous ever since.

The rheumy called in a prescription for Zofran a week ago. She is taking it

all the time and even then she is still experiencing some nausea. It's so

frustrating - the mtx is helping her joints but now she feels miserable from

the side effects. She doesn't see the rheumy until Feb. 23. I don't know

whether to call him or not. I don't even know what the alternatives are.

Amy and Lucy, 6 poly

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My daughter has been on MTX injections for over 3 years now. At first

she has major issues with the vomiting, they seemed to have gone away

after a few months being on it, and they have come back. She throws

up right after the shot, and maybe once after that.

You may want to see if there is something else they can give him.

>

> > Lucy started mtx injections 10 days ago. She has been nauseous ever

> > since.

> > The rheumy called in a prescription for Zofran a week ago. She is

taking it

> > all the time and even then she is still experiencing some nausea.

It's so

> > frustrating - the mtx is helping her joints but now she feels

miserable

> > from

> > the side effects. She doesn't see the rheumy until Feb. 23. I

don't know

> > whether to call him or not. I don't even know what the

alternatives are.

> >

> > Amy and Lucy, 6 poly

> >

> >

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The rheumy wants to take Lucy off of mtx. She's supposed to start Enbrel

tomorrow, but we have to wait for the insurance to approve it and then the

pharmacy to order it. Neither of those things happened today, so she won't

be starting Enbrel until next week. I'm hopeful though.

Amy and Lucy, 6, poly

Re: MTX side effects

My daughter has been on MTX injections for over 3 years now. At first

she has major issues with the vomiting, they seemed to have gone away

after a few months being on it, and they have come back. She throws

up right after the shot, and maybe once after that.

You may want to see if there is something else they can give him.

>

> > Lucy started mtx injections 10 days ago. She has been nauseous ever

> > since.

> > The rheumy called in a prescription for Zofran a week ago. She is

taking it

> > all the time and even then she is still experiencing some nausea.

It's so

> > frustrating - the mtx is helping her joints but now she feels

miserable

> > from

> > the side effects. She doesn't see the rheumy until Feb. 23. I

don't know

> > whether to call him or not. I don't even know what the

alternatives are.

> >

> > Amy and Lucy, 6 poly

> >

> >

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Hi,

My son has been on Enbrel for 6+ yrs now and it was his miricle drug.I hope and

pray Lucy has the same results.

Becki and 10 systemic onset

________________________________

From: hendricksonhouseful <nuestrasenora@...>

Sent: Thursday, January 29, 2009 9:52:53 PM

Subject: RE: MTX side effects

The rheumy wants to take Lucy off of mtx. She's supposed to start Enbrel

tomorrow, but we have to wait for the insurance to approve it and then the

pharmacy to order it. Neither of those things happened today, so she won't

be starting Enbrel until next week. I'm hopeful though.

Amy and Lucy, 6, poly

Re: MTX side effects

My daughter has been on MTX injections for over 3 years now. At first

she has major issues with the vomiting, they seemed to have gone away

after a few months being on it, and they have come back. She throws

up right after the shot, and maybe once after that.

You may want to see if there is something else they can give him.

>

> > Lucy started mtx injections 10 days ago. She has been nauseous ever

> > since.

> > The rheumy called in a prescription for Zofran a week ago. She is

taking it

> > all the time and even then she is still experiencing some nausea.

It's so

> > frustrating - the mtx is helping her joints but now she feels

miserable

> > from

> > the side effects. She doesn't see the rheumy until Feb. 23. I

don't know

> > whether to call him or not. I don't even know what the

alternatives are.

> >

> > Amy and Lucy, 6 poly

> >

> >

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Hmmm I wonder if the methotrexate is causing my gyn problems. I have a

solid type cyst on my left ovary? Anyone else on this topic? My rheumy

never mentioned any of this

Jolene

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Patty B

I also had a bad reaction to MTX and Enbrel.

Used MTX for about 6 yrs. then it started to bother my kidneys. Dr.

said that's not possible -- I told him I'm not taking it any longer.

Enbrel -- I had 3 injections before a big flare up or rash from head

to toe.

I haven't tried anything else so far.

SD

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Yes, I had tongue sores when I took it. It wasn't much of a

problem when I took only the MTX and no biologics, but in combination

with Enbrel, Humira, Remicade, or my current [and last chance that

they can offer just now] I couldn't also take the MTX. The others

all controlled my psoriasis plaques, but the one I " m currently

taking is not controlling the plaques. I didn't give the name

simply because mental mud just took it out of my mind...It will come

to me too late to reply.

" salo99@... " <salo99@...>

> I keep reading all the wonderful things that MTX has done for so

> many of you and cannot help wondering if there are any others out

> there that were unable to take MTX.

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Hi Jolene,

<<Hmmm I wonder if the methotrexate is causing my gyn problems. I

have a solid type cyst on my left ovary?>>

It would be a good idea to have it checked out.

<<Anyone else on this topic? My rheumy never mentioned any of this>>

I think that's what upset me the most -- they didn't go over some of

the negative side effects. In fact, no one even instructed me on how

to give myself the instructions. I got them ON THE PHONE from the

nurse with Enbrel! They were always very helpful with ANY questions.

You might even call them to ask about your problems.

I hope you don't delay seeing a gynecologist or at least your primary

care doctor to relieve your mind one way or the other.

Patty B.

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Hi Patty,

> Were you taking folic acid with MTX? The folic acid should

> eliminate the mouth sores.

Yes, I was taking Folic Acid every day but the rheumy didn't want me

to take more than 2 tabs. (I mentioned that I'd read where others took

as many as 5.); she was adamant about that saying she was going by the

levels reported in my blood work.

The Staph in my nose was the normal staph found in everybody. I

suspect my immune system had been lowered too much and it became an

opportunistic infection. We have to stop Enbrel during any infection

and I just never started it again. I was too SCARED! of all of it by

then.

Patty B.

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Hi SD,

> Enbrel -- I had 3 injections before a big flare up or rash from head

> to toe.

I'm surprised about your skin's reaction to beginning Enbrel. My skin

cleared up completely (although there were only a few patches mostly

my elbows to begin with).

About 9 months after stopping the MTX & Enbrel, my skin really

breaking out -- worse in years. I'm not sure if it's a reaction to

stopping those medications because they DO say it can but it seems

like a very delayed reaction to me. Dunno ....

Patty B.

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Patty B

The rash I had from taking Enbrel was an allergic reaction not

psoriasis.

And after about a year off of Enbrel and MTX my psoriasis also got much

worse. I believe the MTX does a lot to help with our rash and maybe it

takes a lot time to get these meds out of our system.

I'm really not sure what to try next?????

SD

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Hi Jolene,

<<Oh I've seen the gyn I have surgery scheduled on February 18>>

I'm sorry that surgery is needed rather a more conservative treatment.

Do you mind sharing his opinion about whether the cause is related to

MTX or what the diagnosis is?

Please do take good care of yourself,

Patty B.

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Yes I have to have the surgery the cyst I have on my ovary is solid and that

s what concerns them. If it hadn't of grown they would just leave it but it

is. So they are taking the tube, the ovary and of course the cyst. I do

have one on the other side its just small not sure if they are taking that

or not. I have not talked to my rheumatologist about this as of yet. I am

now on now methotrexate starting this week and two weeks after surgery so

not sure what is going to happen. I will ask my gyn about the methotrexate

causing this. To be honest I never had any problems woman wise with cycles

till I started the methotrexate. Strange isn't it. Its going to be

interesting to see how I am without the methotrexate. I also have complex

regional pain syndrome which complicates that too. When I get an answer ill

post it to the group.

Jolene

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