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Citrulline

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Ive ordered some supplements to help me build up ..but one of the actions of

citruline is to increase nitric oxide which isnt desireable if you have CFS

....so Im cancelling the order..

Regards

CS

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  • 3 years later...
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The following information was found at www.wikipedia.com

<http://www.wikipedia.com> and Springboard

Watermelons contain a significant amount of Citrulline and after

consumption of several kg, an elevated concentration is measured in the

blood plasma, this could be mistaken for Citrullinaemia or other urea

cycle disorder.

Patients with RA often have detectable antibodies against proteinis

containing citrulline. Although the origin of this immune response is

not known, detection of antibodies reactive with citrulline

(anticitrullinated protein antibodies) containing proteins or peptides

is now becomiing an important help in the diagnosis of Rheumatoid

Arthritis.

In recent studies, citrulline has been found to relax blood vessels.

Citrulline is a nonessential amino acid, which means that it is not

manufactured from other amino acids in the liver; it does not have to be

obtained directly through the diet.

Citrulline is a precursor to arginine (Arginine is a contributing member

of the various amino acids found in the urea cycle, which is responsible

for detoxifying ammonia. Ammonia is a by-product of bacterial

metabolism in the intestinal tract and must be detoxified iin the liver.

The urea cycle is also responsible for eliminating other catabolic

sources of nitrogen so the body does not build up toxic nitrogen

metabolites.)and is involved in the formation of urea in the liver. The

synthesis and elimination of urea is essential for removing toxic

nitrogen metabolites from the body. These metabolites build up from the

digestion, absorption, and metabolism of protein.

Citrulline works along with aspartic acid, citric acid, and magnesium in

helping to improve nitrogen metabolite excretion.

Studies suggest that deficiencies may occur in some infants and adults

because the rate of production may not be equal to their need.

No therapeutic application of citrulline has been identified. Some

individuals possess a genetic defect which prevents proper conversion of

citrulline to arginine. This results in the buildup of citrulline in

the blood and a deficiency of arginine. This condition is associated

with ammonia build up in the body and symptoms such as irritability and

mental confusion. Zinc and vitamin B-6 are useful for promoting the

conversion of citrulline to arginine.

Take Care everyone,

(musiclvr3237)

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