RESEARCH - Serotonin-blocking antidepressants linked to joint disorders

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Serotonin-Blocking Antidepressants Linked to Joint Disorders

NEW YORK (Reuters Health) Nov 12 - The use of serotonin receptor 2A

(5-HT2A)-blocking antidepressants may increase the risk of various

joint disorders, researchers report in the October 15th issue of

Arthritis and Rheumatism.

" From published case reports and cases series, it has been suggested

that 5-HT2A-blocking antidepressant drugs may cause joint disorders, "

Dr. Anders Kling, of University Hospital, Umea, Sweden, and colleagues

write. " These reports could be a signal of a true adverse drug

reaction (ADR), but could also simply be a result of coincidence

because arthritis and arthralgia, even without established rheumatic

disease, are common in general populations. "

In a retrospective study, the researchers examined whether the use of

5-HT2A-blocking atypical antidepressants is associated with joint

disorders. The authors assessed reports of ADRs concerning joint

disorders that were suspected to be linked to use of any of three

5-HT2A-blocking atypical antidepressants (mianserin, mirtazapine, and

nefazodone).

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Read the full article here:

http://www.medscape.com/viewarticle/712311

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