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Plasma 25,OH vitamin D concentrations are not associated with RA-related autoantibodies in individuals at elevated risk for RA

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J Rheumatol. 2009 Mar 13.

Plasma 25,OH Vitamin D Concentrations Are Not Associated with

Rheumatoid Arthritis (RA)-related Autoantibodies in Individuals at

Elevated Risk for RA.

Feser M, Derber LA, Deane KD, Lezotte DC, Weisman MH, Buckner JH,

Mikuls T, O'Dell J, Gregersen PK, Holers VM, Norris JM.

From the Department of Epidemiology, Colorado School of Public Health,

University of Colorado Denver, Denver, Colorado; Division of

Rheumatology, Department of Medicine, University of Colorado Denver,

Aurora, Colorado; Department of Biostatistics, Colorado School of

Public Health, University of Colorado Denver, Denver, Colorado;

Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles,

California; Translational Research Program, Benaroya Research

Institute, Seattle, Washington; Section of Rheumatology and

Immunology, Department of Internal Medicine, University of Nebraska

Medical Center, Omaha, Nebraska; and the Feinstein Institute for

Medical Research, Manhasset, New York, USA.

OBJECTIVE: To evaluate the association between rheumatoid arthritis

(RA)-related autoantibodies and plasma 25,OH vitamin D in subjects at

risk for RA.

METHODS: In 1210 subjects without RA, 76 were positive for anti-cyclic

citrullinated peptide antibodies or for at least 2 rheumatoid factors

(RF; by nephelometry: RF-IgM, RF-IgG, RF-IgA). 25,OH vitamin D was

measured in these cases and 154 autoantibody-negative controls from

this cohort.

RESULTS: 25,OH vitamin D levels did not differ between cases and

controls (adjusted OR 1.23, 95% CI 0.93-1.63). C

ONCLUSION: Vitamin D concentrations are not associated with RA-related

autoimmunity in unaffected subjects at increased risk for RA.

PMID: 19286844

http://www.ncbi.nlm.nih.gov/pubmed/19286844

Not an MD

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Interesting article, . That shoots a big hole in another " theory " I heard

about on one of those infomercials when they said that correcting a Vitamin D

deficiency would help with " arthritis " . People really need to be careful and

beware. There are so many " snake oil salesmen " out there who are only looking to

make a quick buck by touting " miraculous " results with their products that are

aimed at difficult to treat diseases.....Doreen :)

>

> J Rheumatol. 2009 Mar 13.

>

>

> Plasma 25,OH Vitamin D Concentrations Are Not Associated with

> Rheumatoid Arthritis (RA)-related Autoantibodies in Individuals at

> Elevated Risk for RA.

>

>

> Feser M, Derber LA, Deane KD, Lezotte DC, Weisman MH, Buckner JH,

> Mikuls T, O'Dell J, Gregersen PK, Holers VM, Norris JM.

>

> From the Department of Epidemiology, Colorado School of Public

> Health, University of Colorado Denver, Denver, Colorado; Division of

> Rheumatology, Department of Medicine, University of Colorado Denver,

> Aurora, Colorado; Department of Biostatistics, Colorado School of

> Public Health, University of Colorado Denver, Denver, Colorado;

> Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles,

> California; Translational Research Program, Benaroya Research

> Institute, Seattle, Washington; Section of Rheumatology and

> Immunology, Department of Internal Medicine, University of Nebraska

> Medical Center, Omaha, Nebraska; and the Feinstein Institute for

> Medical Research, Manhasset, New York, USA.

>

>

> OBJECTIVE: To evaluate the association between rheumatoid arthritis

> (RA)-related autoantibodies and plasma 25,OH vitamin D in subjects

> at risk for RA.

>

> METHODS: In 1210 subjects without RA, 76 were positive for

> anti-cyclic citrullinated peptide antibodies or for at least 2

> rheumatoid factors (RF; by nephelometry: RF-IgM, RF-IgG, RF-IgA).

> 25,OH vitamin D was measured in these cases and 154 autoantibody-

< negative controls from this cohort.

>

> RESULTS: 25,OH vitamin D levels did not differ between cases and

> controls (adjusted OR 1.23, 95% CI 0.93-1.63). C

>

> CONCLUSION: Vitamin D concentrations are not associated with

> RA-related autoimmunity in unaffected subjects at increased risk

> for RA.

>

>

> PMID: 19286844

>

> http://www.ncbi.nlm.nih.gov/pubmed/19286844

>

>

>

> Not an MD

>

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