REVIEW - What can the periodontal community learn from the pathophysiology of RA?

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J Clin Periodontol. 2011 Mar;38 Suppl 11:106-13. doi:

10.1111/j.1600-051X.2010.01669.x.

What can the periodontal community learn from the pathophysiology of

rheumatoid arthritis?

Culshaw S, McInnes IB, Liew FY.

Glasgow Dental Hospital and School, University of Glasgow, Glasgow, UK.

Abstract

AIM: The aim of this paper is to provide a narrative review of the

aetiopathogeneis and treatments of rheumatoid arthritis (RA), focusing

on aspects that may share commonality with periodontitis.

RESULTS: A myriad of cell types, cytokines and pathways have been

investigated in both periodontitis and RA. Chronic inflammatory

diseases, including RA, psoriatic arthritis, ankylosing spondylitis

and periodontitis are likely to share pathogenic mechanisms of

inflammation-mediated solid tissue destruction. The aetiopathogenesis

of these diseases has been extensively researched over the last

several decades and advances in understanding have revolutionized

arthritis therapeutics.

CONCLUSION: The rational, targeted inhibition of mediators in RA has

provided clinically useful therapeutics and shed light on mechanisms

underpinning disease pathogenesis. RA should be considered a

prototypic disease revealing how understanding disease pathogenesis

may transform therapeutic options and patient outcomes.

PMID: 21323707

http://www.ncbi.nlm.nih.gov/pubmed/21323707

Not an MD