Fwd: Know the facts with ENBREL.

[Guest guest]

Hi,

I received this last night and thought that this may be helpful for those

considering going on Enbrel. There are many links to click for further

reading.

Heidi in Mass.

_

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From: amgenwyeth@...

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Sent: 3/30/2009 8:45:27 P.M. Eastern Daylight Time

Subj: Know the facts with ENBREL.

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Enliven® Services: Advice, assistance,

and answers for people taking ENBREL _Important Safety Information_

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INDICATION

Moderate to Severe Rheumatoid Arthritis (RA)

ENBREL is indicated for reducing signs and symptoms, keeping joint damage

from getting worse, and improving physical function in patients with moderate

to severe rheumatoid arthritis. ENBREL can be taken with methotrexate or used

alone.

* In medical studies, ENBREL was shown to be effective in about 2 out

of 3 adults with RA who used it, and has been shown to begin working in as

few as 2 weeks, with most patients receiving benefit within 3 months. In an RA

medical study, 55% of patients had no progression of joint damage.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ENBREL?

ENBREL is a medicine, called a tumor necrosis factor (TNF) blocker, that

blocks the action of a substance your body's immune system makes, called TNF.

People with immune diseases, such as rheumatoid arthritis, juvenile idiopathic

arthritis, ankylosing spondylitis, psoriatic arthritis, or psoriasis, have

too much TNF in their bodies. ENBREL can reduce the amount of active TNF in

the body to normal levels, helping to treat your disease. But, in doing so,

ENBREL can lower the ability of your immune system to fight infections.

Serious infections have happened in patients taking ENBREL. These

infections include tuberculosis (TB) and infections caused by viruses, fungi,

or

bacteria that have spread throughout the body. Some patients have died from

these

infections. Many of these serious infections occurred in people prone to

infection, such as patients with advanced or poorly controlled diabetes. Do not

start ENBREL if you have an infection or are allergic to ENBREL or its

components. Once on ENBREL, if you get an infection or have any sign of an

infection, including fever, cough, or flu-like symptoms, or have open cuts or

sores,

tell your doctor.

Serious nervous system disorders, such as multiple sclerosis, seizures, or

inflammation of the nerves of the eyes have been reported. There have been

rare reports of serious blood disorders (some fatal).

In medical studies, more cases of lymphoma (a type of cancer) were seen in

patients taking TNF blockers compared to similar patients who were not taking

TNF blockers. The risk of lymphoma may be several-fold higher in people with

rheumatoid arthritis and psoriasis. The role of TNF blockers in the

development of cancer is unknown.

Tell your doctor if you:

* Think you have an infection. You should not start taking ENBREL if

you have any kind of infection.

* Have any open cuts or sores

* Have TB or have been in close contact with someone who has had TB

* Were born in, lived in or traveled to countries where there is more

risk for getting TB. Ask your doctor if you are not sure.

* Live or have lived in certain parts of the country (such as, the

Ohio and Mississippi River valleys, or the Southwest) where there is a greater

risk for certain kinds of fungal infections, such as histoplasmosis. These

infections may develop or become more severe if you take ENBREL. If you don't

know if histoplasmosis or other fungal infections are common in the areas

where you live or have lived, ask your doctor.

* Have or have had hepatitis B

* Have ever been diagnosed with or treated for heart failure

* Have ever had or if you develop a serious nervous system disorder

* Develop symptoms such as persistent fever, bruising, bleeding, or

paleness while taking ENBREL

Common side effects in adult clinical trials were injection site reaction,

infection and headache.

If you have any questions about this information, be sure to discuss them

with your doctor. You are encouraged to report negative side effects of

prescription drugs to the FDA. Visit _www.fda.gov/medwatch_

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call 1-800-FDA-1088.

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_Medication Guide_

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