REVIEW - Effects of tobacco smoke on immunity, inflammation, and autoimmunity

[Guest guest]

J Autoimmun. 2010 May;34(3):J258-65. Epub 2009 Dec 29.

Effects of tobacco smoke on immunity, inflammation and autoimmunity.

Arnson Y, Shoenfeld Y, Amital H.

Department of Medicine D, Meir Medical Center, Kfar Saba, Israel.

Abstract

Smoking is a central factor in many pathological conditions. Its role

in neoplasm, lung and cardiovascular diseases has been well

established for years. However it is less acknowledged the cigarette

smoking affects both the innate and adoptive immune arms. Cigarette

smoke was shown to augment the production of numerous pro-inflammatory

cytokines such as TNF-alpha, IL-1, IL-6, IL-8 GM-CSF and to decrease

the levels of anti-inflammatory cytokines such as IL-10. Tobacco smoke

via multiple mechanisms leads to elevated IgE concentrations and to

the subsequent development of atopic diseases and asthma. Cigarette

smoke has also been shown activate in many ways macrophage and

dendritic cell activity. While it is better evident how cigarette

smoke evokes airway diseases more mechanisms are being revealed

linking this social hazard to autoimmune disorders, for instance via

the production of antibodies recognizing citrullinated proteins in

rheumatoid arthritis or by the elevation of anti-dsDNA titers in

systemic lupus erythematosus. The current review underlines the

importance of smoking prevention and eradication not only in

respiratory disorders but also in autoimmune conditions as well.

PMID: 20042314

http://www.ncbi.nlm.nih.gov/pubmed/20042314

Not an MD

[Guest guest]

EEK!!!!!!!!! I quit years ago but lately I've been having a smoke here and there

when I'm really stressed out. Time to knock it off!

Candace

No shadows to depress you

Only joys to surround you

Many friends to love you

God himself to bless you

These are my wishes for you,

For today, tomorrow & everyday.

Sent from my iPhone

On Aug 4, 2010, at 9:07 AM, <Rheumatoid.Arthritis.Support@...>

wrote:

> J Autoimmun. 2010 May;34(3):J258-65. Epub 2009 Dec 29.

>

> Effects of tobacco smoke on immunity, inflammation and autoimmunity.

>

> Arnson Y, Shoenfeld Y, Amital H.

> Department of Medicine D, Meir Medical Center, Kfar Saba, Israel.

>

> Abstract

>

> Smoking is a central factor in many pathological conditions. Its role

> in neoplasm, lung and cardiovascular diseases has been well

> established for years. However it is less acknowledged the cigarette

> smoking affects both the innate and adoptive immune arms. Cigarette

> smoke was shown to augment the production of numerous pro-inflammatory

> cytokines such as TNF-alpha, IL-1, IL-6, IL-8 GM-CSF and to decrease

> the levels of anti-inflammatory cytokines such as IL-10. Tobacco smoke

> via multiple mechanisms leads to elevated IgE concentrations and to

> the subsequent development of atopic diseases and asthma. Cigarette

> smoke has also been shown activate in many ways macrophage and

> dendritic cell activity. While it is better evident how cigarette

> smoke evokes airway diseases more mechanisms are being revealed

> linking this social hazard to autoimmune disorders, for instance via

> the production of antibodies recognizing citrullinated proteins in

> rheumatoid arthritis or by the elevation of anti-dsDNA titers in

> systemic lupus erythematosus. The current review underlines the

> importance of smoking prevention and eradication not only in

> respiratory disorders but also in autoimmune conditions as well.

>

> PMID: 20042314

>

> http://www.ncbi.nlm.nih.gov/pubmed/20042314

>

>

> Not an MD

>