Re: RESEARCH - Postpartum onset of RA and other chronic arthritides

[Guest guest]

Good morning again,

I'm really enjoying reading your posts and hope you don't mind me responding so

much today.  I find this post both interesting and confusing.  I find it

interesting because I have Norwegian ancestry on my birthfather's side.  I find

it confusing because the onset of my RA was within 0-24 months after delivery of

my first born son when I was 21.  I was given

a " something, maybe Rh " hemogloubin shot within hours of giving birth because I

have A - blood and my son had positive blood.

I would find this study more interesting if with the patients they studied, they

could find out

what type blood these patients had, and how many were given the same shot I

was.  I've

kind of always wondered how hereditary immune diseases are....is it in

our blood?

Thank you . and take care.

(musiclvr3237)

From: <Rheumatoid.Arthritis.Support@...>

Subject: [ ] RESEARCH - Postpartum onset of RA and other chronic

arthritides

" " < >

Date: Wednesday, September 9, 2009, 9:31 AM

 

Ann Rheum Dis. 2009 Aug 27.

Post partum onset of rheumatoid arthritis and other chronic

arthritides: results from a patient register linked to a medical birth

registry.

Wallenius M, Skomsvoll JF, Irgens L, Salvesen KA, Koldingsnes W,

Mikkelsen K, Kaufmann C, Kvien TK.

Norwegian University of Science and Technology, Norway.

OBJECTIVE: It is known that onset of rheumatoid arthritis (RA) is

increased post partum. We wanted to compare incidence rates between RA

and other chronic arthritides (OCA) 0-24 months after delivery, and to

compare the incidence rates within each group 0-24 versus 25-48 months

post partum.

METHODS: Premenopausal women from a Norwegian patient register were

linked with the Medical Birth Registry of Norway to study the interval

between delivery and time of diagnosis. regression analysis with

adjustments for age at delivery and birth order was applied to compare

proportions of incident cases of RA and OCA with onset 0-24 months

post partum. Poisson regression analysis with adjustment for

population at risk was applied to estimate incidence rate ratio (IRR)

0-24 versus 25-48 months post partum.

RESULTS: Out of 183 RA and 110 OCA patients diagnosed after delivery,

69 (37.7 %) had RA and 31 (28.2 %) OCA during the first 24 months post

partum (p=0.09). The IRR (95 % CI) for diagnosis during 0-24 months

versus 25-48 months was 1.73 (1.11, 2.70) (p=0.01) for RA, 1.05 (0.59,

1.84) (p=0.86) for OCA. The IRR was 2.23 (1.06, 4.70) and 1.87 (0.67,

5.21), respectively, when only considering diagnoses after 1st

pregnancy. Clinical characteristics were similar within each

diagnostic group.

CONCLUSION: The proportions of incident cases with onset 0-24 months

after delivery were not different between RA and OCA. A peak in

incidence during 0-24 months was seen in the RA group, both when

considering all pregnancies and only the first pregnancy.

PMID: 19717397

http://www.ncbi. nlm.nih.gov/ pubmed/19717397

Not an MD

[Guest guest]

Of course I don't mind when people read and wish to discuss the studies, !

The cause of RA isn't known yet, but there is strong evidence that

there are both genetic prerequisites and environmental triggers

involved.

I think you're referring to RhoGAM. I had six of those and sometimes

wonder about them, but I haven't seen any research on any connection

to immune system dysfunction.

Not an MD

On Wed, Sep 9, 2009 at 9:42 AM, (musiclvr)<musiclvr3237@...> wrote:

> Good morning again,

> I'm really enjoying reading your posts and hope you don't mind me responding

so much today.  I find this post both interesting and confusing.  I find it

interesting because I have Norwegian ancestry on my birthfather's side.  I find

it confusing because the onset of my RA was within 0-24 months after delivery of

my first born son when I was 21.  I was given

> a " something, maybe Rh " hemogloubin shot within hours of giving birth because

I have A - blood and my son had positive blood.

> I would find this study more interesting if with the patients they studied,

they could find out

> what type blood these patients had, and how many were given the same shot I

was.  I've

> kind of always wondered how hereditary immune diseases are....is it in

our blood?

> Thank you . and take care.

> (musiclvr3237)