RESEARCH - Predominance of T cells in the lymphocytic infiltrates of synovial tissues in RA

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Arthritis Rheum. 2008 Feb;58(2 Suppl):S58-65.

Predominance of T cells in the lymphocytic infiltrates of synovial

tissues in rheumatoid arthritis.

Bankhurst AD, Husby G, RC Jr.

Department of Medicine, University of New Mexico School of Medicine,

Alburquerque, New Mexico 87131, USA.

Abstract

Synovial tissues from 5 patients with rheumatoid arthritis (RA) were

examined immunofluorescence microscopy for the presence of lymphocytes

with either bone marrow-derived ( or thymus-derived (T) surface

markers. Five synovial tissues with severe to mild lymphocytic

infiltrations by bright field microscopy were examined in parallel

with immunofluorescence. B cells were identified with a

pepsin-digested fluoresceinated anti-F (ab')2 antiserum and T cells

were detected with a specific rabbit and anti-T lymphocyte antiserum.

By these techniques 75-90% of the lymphocytes in these frozen sections

were identified as T cells. Cell suspensions were also prepared by

collagenase digestion of two of the five synovial tissues. The

lymphocytes in these cell suspensions were predominantly T lymphocytes

(78-85%) as shown by their ability to form spontaneous rosettes with

sheep erythrocytes (E rosettes).

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Read the full article here:

http://onlinelibrary.wiley.com/doi/10.1002/art.23359/pdf

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