RESEARCH - Diffuse lupus encephalopathy in a case of rhupus syndrome

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Rheumatol Int. 2010 May;30(7):961-3. Epub 2009 Jun 18.

Diffuse lupus encephalopathy in a case of rhupus syndrome.

Wang JG, Tang HH, Tan CY, Liu Y, Lin H, Chen YT.

Department of Rheumatology and Immunology, West China Hospital of

Sichuan University, 610041, Chengdu, China.

Abstract

" Rhupus syndrome " is a rare clinical condition, which is related to

anti-CCP antibody, characterized by overlapping clinical and

immunologic features of rheumatoid arthritis and systemic lupus

erythematosus. Previous reports mentioned that patients have more

RA-associated damage, and little organic damage associated with SLE.

The severe organ damage, especially central nervous system involvement

has been reported to be rare in patients with rhupus syndrome. Here,

we report a very rare concurrence of RA, SLE and diffuse lupus

encephalopathy in a Chinese woman.

Introduction

" Rhupus syndrome " is a rare clinical condition characterized by

overlap of clinical and immunologic features of rheumatoid arthritis

(RA) and systemic lupus erythematosus (SLE). Its observed prevalence

was about 0.09%. Patients usually have more RA-associated and less

SLE-associated damage. These patients always have a mild pathogenic

condition except for arthrosis. Severe organ damage, especially

central nervous system (CNS) involvement, has been reported to be rare

in patients with rhupus syndrome. Here, we report the very rare

concurrence of RA, SLE and diffuse lupus encephalopathy in a Chinese

woman.

PMID: 19536547

http://www.ncbi.nlm.nih.gov/pubmed/19536547

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