NCC/Dentist/TO STEPHEN

[Guest guest]

Hi ,

I did a search for you and found this information! Its 7:15 am and only

had three hours sleep last night, so had nothing better to do! Smile! I

hope it helps some! I hope you start to feel better real soon! God

bless Robin

Metronidazole: Adverse Reactions

High doses or long-term administration of metronidazole can cause

a peripheral neuropathy with sensory disturbances e.g. at the hands and

feet. Neuropathy is often only slowly reversible or not reversible at

all.

Neutropenia can also develop. Metallic taste in the mouth, nausea,

upper abdominal pain, or headaches sometimes occur following usual

therapeutic doses. Convulsions, ataxia, skin problems (skin rashes,

urticaria), and vaginal candidiasis are not as common. Isolated cases of

pancreatitis, cystitis, mucous colitis, and hemolysis have been

observed. Mutagenic effects have been observed in animal experiments;

no carcinogenic effect has yet been demonstrated in man.

Metronidazole: Interactions

Metronidazole can reinforce the effect of oral anticoagulants. A

combination with cimetidine results in higher metronidazole levels.

Antabus reactions were observed when combined with alcohol.

Concomitant administration of disulfiram can cause psychotic

reactions.

****************

Metronidazole, a synthetic 5-nitroimidazole, has an antibiotic action

that is based on the modification of the genetic substance of

microorganisms. Its spectrum contains anaerobic bacteria (bacteroides

fragilis, clostridia, fusobacteria, peptococci, peptostreptococci),

certain other bacteria (e.g. gardnerella vaginalis), and protozoas

(giardia lamblia, entameba hystolytica, trichomonas vaginalis).

Bactericidal tissue

concentrations are achieved in the central nervous system, in the

liver and the bile ducts, in the bones, in vaginal secretions, and in

the pelvic organs.