Fwd: Very Important 3 New Studies - Dr. Mark Geier & Geier

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Ana Brushingham

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> Subject: Fwd: Very Important 3 New Studies - Dr. Mark Geier

> & Geier

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> Date: Sunday, November 16, 2008, 4:52 PM

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> ----- Forwarded Message -----

> Subject: Very Important 3 New Studies - Dr. Mark Geier

> & Geier

>

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> Dear Everyone,

>  

> This email is to give a status update regarding the

> continuing avalanche of ever increasing numbers of studies

> that are emphatically supporting and extending the theory

> that mercury exposure, and particularly, mercury exposure

> from Thimerosal-containing vaccines plays a significant role

> in causing autism and other neurodevelopmental disorders.

>  

> First, and perhaps most importantly, is the first

> epidemiological peer-reviewed study on US children (other

> than our own extensive body of peer-reviewed studies) to

> show a statistically significant increased risk for

> neurodevelopmental disorders following exposure to

> increasing doses of mercury from Thimerosal-containing

> childhood vaccines. This study is attached to this email

> saved as Hepatitis B triple series vaccine and developmental

> disability in US children aged 1-9 years1.pdf in Adobe

> Acrobat Format.

>  

> This study was published in the journal of Toxicological

> and Environmental Chemistry by newly published researchers

> on Thimerosal from the School of Public Health, Stony Brook

> University Medical Center, Health Sciences Center, State

> University of New York at Stony Brook.

>  

> These researchers reported their, " study investigated

> the association between the hepatitis B triple serieis

> vaccination in children age 1-9 years and developmental

> disability, proxied by parental report of early intervention

> or special education services (EIS) in the 1999-2000

> National Health and Nutrition Examination Survey

> (NHANES). "

>  

> Further, they stated, " while this study uses EIS as a

> proxy for developmental disability in general, but not

> specifically autism, autism mertis consideration because it

> is a develpmental disorder with recent notable impacts on

> EIS. The number of children receiving special education

> services for autism increased 500% from 1991/92 to 1998/99

> (CDC 2007b). "

>  

> Finally, " vaccination with hepatitis B triple series

> vaccine during the time period vaccines were manufactured

> with Thimerosal exposed newborns and infants to ethylHg (CDC

> 2000). By using NHANES 1999-2000 data for children age 1-9

> years of age, children who were candidates for the

> Thimerosal-containing triple series hepatitis B vaccine were

> included in the study sample. The eldest children who

> received the triple series hepatitis B vaccine would have

> been vaccinated during 1991, the first year that the

> thimerosal-containing vaccine was recommended for newborns

> (CDC 1991), while the youngest children would have been

> vaccinated during 1999, the last full year of known access

> to only Thimerosal-containing vaccines (CDC 2000). "

>  

> These researchers reported, " The study sample data set

> was obtained from the National Health and Nutrition

> Examination Survey (NHANES) 1999-2000 data set, which

> included a total of 9965 participants - both adults and

> children. NHANES is a cross-sectional, random household

> survey of the civilian population based on a complex

> probability sampling design. The survey is a continous

> program of the National Center for Health Statistics (CHS),

> which is a part of the Centers for Disease Control and

> Prevention (CDC). NHANES provides information about the

> distribution of health problems and risk factors that

> contribute to poor health outcomes. In addition to

> conducting interview of almost 10,000 persons per year, the

> survey examines a nationally representative of about 5000

> persons each year. The sample for the survey is selected to

> represent the US population of all ages...Epidemiologists

> and health science researchers use NHANES data to generate

> findings that

> provide guidance for public health policy development and

> health program design. NHANES data provide researchers with

> important clues to the causes of disease (CDC 2004a). "

>  

> In the present study, the researchers examined the status

> of hepatitis B vaccination among the participants examined.

> A total of 1,824 observations included children aged 1-9

> years of age and with parents who answered either

> 'yes' or 'no' to the survey questions,

> " Does your child receive Special Education or Early

> Intervention Services? " Participants were evaluated

> that had either received a full course of hepatitis B

> vaccination or were unvaccinated, and a number of other

> variables were considered in evaluating the children. The

> researchers conducted statistical analyses using SAS, and

> analytical methods employed were those previously suggested

> by the NCHS of the CDC.

>  

> These researchers reported regarding their findings,

> " the odds of receiving EIS were approximately nine

> times as great for vaccination boys (n=46) as for

> unvaccinated boys (n=7) after adjustment for

> confounders. "

>  

> The researchers strongly concluded, " This study

> contributes to answering an unresolved question of the

> Institute of Medicine¢s (IOM¢s) 2001 Immunization Safety

> Review (IOM 2001) as well as the same question not addressed

> by the IOM¢s 2004 review (IOM 2004), namely, whether there

> is an association between thimerosal-containing vaccines and

> neurodevelopmental disorders, in general (McCormick 2004).

> As did the IOM in their 2004 study, et al. (2004)

> more specifically concluded that studies did not demonstrate

> a link between thimerosal-containing vaccines and autism,

> and cited supporting evidence from cohort studies conducted

> in the United Kingdom (UK), Denmark, and Sweden. However,

> unlike the United States, past (CDC 1991; CDC 1998) and

> present (CDC 2006b), these countries¢ vaccination

> schedules do not recommend universal vaccination of newborns

> with the Hepatitis B vaccine (ECDC 2006a, . Sweden

> recommends that Hepatitis B be given at birth

> only to infants of mothers positive for Hepatitis B (ECDC

> 2006c). In 1998, the UK vaccinated newborns with the

> Hepatitis B vaccine, but again, only to infants of mothers

> positive for Hepatitis B (Ovetchkine and Reinert 1998).

> Thus, it is reasonable to question the applicability of

> findings from the UK, Denmark and Sweden studies to the US

> immunized pediatric population. This study found

> statistically significant evidence of an association between

> the thimerosal-containing Hepatitis B triple series vaccine

> and EIS, a proxy for developmental

> disability. Although Hepatitis B vaccines administered to

> children in United States no longer contain thimerosal,

> those administered to children in developing countries

> without the means to prepare single dose vials do contain

> thimerosal (WHO 2004, 2006). Moreover, influenza vaccines

> distributed in United States do contain thimerosal (CDC

> 2006a). Thus, children¢s previous and potential future

> exposure to thimerosal remains an important public health

> concern. Future research should (1) examine how public

> health efforts might better identify harmful exposures and

> susceptible children; (2) institute effective protective and

> quality improvement measures; (3) conduct cost-benefit

> analyses that more comprehensively consider the costs and

> more accurately assess the risks for the US population of

> children, especially subpopulations of susceptible

> children. "

>  

> Second, a study, " Vaccine Preservative, Thimerosal,

> Causes Wide-Spread Neurodevelopmental Disturbances in Young

> Rats " by Researchers from University of Warsaw,

> Dpartment of Pharmacology, Institute of of Psychiatry and

> Neurology, including the Marie Curie Chair, European Union,

> was presented at the International Conference on Autism and

> Vaccinations: Is There a Link? at the University of Warsaw

> (October 25-26, 2008). We attended this conference and had

> meetings with many of the researchers from various European

> countries (including Poland, Germany, England, and France),

> as well as US researchers, presenting evidence of the role

> of mercury, and in particular, Thimerosal, as a causal

> factor for autistic disorders. A copy of an abstract from

> the above cited study published in the conference

> proceedings is attached to this email saved as Vaccine

> Preservative Thimerosal Causes Wide Spread

> Neurodevelopmental Disturbances in Young Rats1.pdf in Adobe

> Acrobat

> Format.

>  

> These researchers described, " in this study, we

> examined the potential neurotoxic effects of Thimerosal,

> which was administered to rat pups i.m. on postnatal days 7,

> 9, 11, 14 in four equal doses, mimicking infants'

> immunization scheme. We monitored mercury distribution to

> different organs, general animal development, conducted

> several behavioral tests and examined the brains for

> neuropthaological changes. The following evahvioral tests

> were chosen to monitor alterations of rats' beavior in

> the context of beahviors observed in Autism Spectrum

> Disorders: motor acitivity in the open field, pain reaction

> and pain sensitivity (hot plate), sociation interactions,

> learning and memory (water maze). Brain hisopathological

> obsercations (H & E and immunohistochemsitry - GFAP,

> neurofilaments, synaptophysins) were carried out as

> well. "

>  

> These researchers observed, " mercury from postnatally

> administered Thimerosal accumulated in several organs and

> remained there in large amounts for at least 30 days...The

> brain contained 13-18% of the amount of mercury originally

> injected i.m., calculated per tissue/body weight. Mercury

> remained in the brain in significant amounts at least for 30

> days after Thimerosal injection. "

>  

> Further, " the animals exposed postnatally to

> Thimerosal had noticeably impaired locomotor acitivity. They

> were significantly slower in the open field and in water

> maze, and exhibited more anxiety than control rats. They had

> markedly impaired pain reactions, measured in hot plate test

> and their social interactions were disturbed. "

>  

> Finally, " the brain weights of Thimerosal injected

> rats were signficantly reduced and there were wide spread

> morphological and pathological changes in several brain

> regioins, particularly in the cerebral cortex, striatum,

> amygdale, hippocampus and the cerebellum.

>  

> These researchers concluded, " the multiple behavioral

> and neuropathological changes observed in young rats exposed

> postnally to Thimerosal confirm that this vaccine

> preservative is neurotoxic to the developing mammalian

> organisms. As such it could be responsible, in part, for the

> brain and other organs damage in children, exposed to it in

> many vaccines. "

>  

> Third, we have attached to this email a copy of a new

> peer-reviewed study (in press) from the journal of

> Environmental Health saved as Feeding Mice with Diets

> Containing Low Dose Methylmercury-Fish & Adverse

> Effects1.pdf in Adobe Acrobat Format.

>  

> The importance of this study is that it examines very, very

> low dose exposure to postnatal methylmercury dosing and its

> effects on behavioral testing, brain and other organ

> pathology (as measured by gene expression), and

> mitochondrial dysfucntion in mice. The dosing regiments

> resulted in brain levels of mercury as follow:

>  

> Low Dose = 5 parts-per-billion (equal to the amount of

> mercury presumed to present in Hornig et al.'s mouse

> model of Thimerosal induced autism, and 10-fold lower than

> that present in the brain of Burbacher et al.'s infant

> monkeys dosed with Thimerosal-containing vaccines mimicking

> the US childhood vaccine schedule.

>  

> Medium Dose = 63 parts-per-billion (about equal to the

> brain mercury level present in Burbacher et al.'s

> Thimerosal-exposed infant monkeys)

>  

> High Dose = 299 parts-per-billion (about 5-fold higher to

> the mercury level present in the brain of Burbacher et

> al.'s Thimerosal-exposed infant monkeys, and within a

> few fold of the brain mercury level of Burbacher et

> al.'s methylmercury exposed infant monkeys).

>  

> These researchers observed that mercury expoure at all the

> levels examined induced significant differences in gene

> expression related to mitochondrial metabolism, oxidiative

> stress, detoxication processes, and cellular apoptosis. It

> was observed in the hippocampus region of the brain (a key

> damaged area in autism) that the moderate dose of mercury

> exposure significantly induced up-regulation of genes

> associated with oxidative stress, detoxification processes,

> and cellular apoptosis (i.e. cell programmed death).

>  

> Further, these researchers observed that significant

> mitochondrial dysfunction was observed even in the low dose

> exposure group, and that the type of damage that occured

> involved cytochrome c oxidase (a key component of electron

> transport in the mitochondrial), which previously reported

> to be abnormal in many children diagnosed with autistic

> disorders.

>  

> Finally, these researchers observed that in the low and

> moderate dose groups significant negative impacts were

> observed in behaviors as measured in a large battery of

> beavhioral measurements.

>  

> If anyone has questions/comments concerning the materials

> provided, please contact us.

>  

> Sincerely,

> Dr. Mark Geier

> Geier