Guest guest Posted January 30, 2000 Report Share Posted January 30, 2000 Hi, everyone... just a quick question... what is Trypsinogen? My brother is being tested for the CF gene & the insurance said they'd pay (without a fight!) with proof had it, so I dug out the lab report with the dx, and it shows the DF508 mutations, and also the trypsinogen level which apparently they measured. I have no idea what it is? Thanks, Elaine _______________________________________________________ Get 100% FREE Internet Access powered by Excite Visit http://freeworld.excite.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 31, 2000 Report Share Posted January 31, 2000 Hi Elaine, Can't exactly give you a " what " , but i can take a shot at the " why " . The WI newborn screen tests for trypsin in the heel prick screening test because babies wcf have high trypsin levels. If the trypsin's high, then they proceed to screen for deltaF508 (and some other mutations in newborn screens in other states-- since we got sort of screwed by the fact that they ONLY checked M. for deltaF508, and thus missed the fact that M. has R117H, and then missed her dx for 4 years because of a negative sweat test, I think they should run the blood through the 70-mutation test once they get a high trypsin level!). Anyway, Kailin, who does not have CF, also had a high newborn trypsin level. She was 4 weeks early, and they told us that prematurity can also cause high trypsin. We found out later that she does carry R117H, so maybe all carriers have high newborn trypsin screens (don't know on that one). Quote Link to comment Share on other sites More sharing options...
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