SchaferAutismReport: Landmark Study: Autism Recognized As Medically Treatable

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RESEARCH

Landmark Study: Autism Recognized As Medically Treatable

Clue to Cause of Epileptic Seizures Discovered

Virtual Faces Created With Emotions, Moods And Personality

PUBLIC HEALTH

One In 3 Toys Is Toxic, Group Says

Scientists Back Brain Drugs For Healthy People

PEOPLE

Girl Scouts Find Room For Autistic Girl

7-Year-Old Holt Boy Recovering From Bathtub Burns

Investigator: Drowning Accidental

MEDIA

Autism Life Skills: Self-Esteem

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RESEARCH

Landmark Study: Autism Recognized

As Medically Treatable

In April of 2008, the American College of

Medical Genetics (ACMG), an AMA- recognized board, issued clinical practice

guidelines that clinical geneticists should follow in determining the

etiology for those with an autistic spectrum disorder (ASD) diagnosis and

in treating patients with this diagnosis. This study, “Autism spectrum

disorder-associated biomarkers for case evaluation and management by

clinical geneticists” in Expert Review of Molecular Diagnostics,1 confirms

that there are now well- established, routine, clinically available,

identified biomarkers to help clinical geneticists medically evaluate and

treat individuals diagnosed with an ASD and briefly outlines some

recognized biomarkers. Depending on the cause of the ASD, these researchers

have found that “associated medical risks may be identified, which may lead

to screening and potential morbidity prevention in patients and other

family members.” The non-profit CoMeD, Inc., and, through a grant from the

Brenen Hornstein Autism Research & Education (BHARE) Foundation, the

non-profit Institute of Chronic Illnesses, Inc. funded this research study.

The important clinical tools identified for

medical evaluation and treatment response monitoring included:

• Pophyrin biomarkers – to help determine if

mercury toxicity is present, and, when it is found, to monitor changes in

mercury-burden during detoxification therapies.

• Trans-Sulfuration biomarkers – to help

determine if mercury biochemical susceptibility is present and, when it is

found, to monitor patient response during supplementation with nutritional

therapies such as methylcobalamin (the methyl form of vitamin B12), folinic

acid, and pyroxidine (vitamin B6).

• Oxidative Stress/Inflammation biomarkers –

to help determine if there are excessive by-products of metabolic pathways,

and, when they are found, to monitor patient progress during

supplementation with anti-inflammatory drugs such as Aldactone®

(spironolactone).

• Hormonal biomarkers – to help determine if

hormonal abnormalities are present and, when they are found, to monitor patient

progress during the indicated treatment with hormonal regulation drugs such

as Lupron® (leuprolide acetate) and Yaz® (drospirenone/ethynyl estradiol).

• Mitochondrial Dysfunction biomarkers – to

help determine if there are disruptions in the energy production pathways,

and, when they are found, to monitor patient progress during

supplementation with drugs such as Carnitor® (L-carnitine).

• Genetic biomarkers – to help determine if

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Vol. 12 No.

172p

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