Re: DES or Estradiol Patches

[Guest guest]

Emerson wrote:

> It looks like it's time for me to make a change in my

> treatment. My PSA from Monday went from 103 on 2/1 to 159 on

> 3/1

> I am currently on HDK/HC and have already failed Casodex,

> Nilandron and a previous course of HDK/HC. Additionally, I did

> a 12 session Chemo round between June 08 and Jan 09. Currently

> I am not interested in a Phase III placebo controlled trial,

> such as Abiraterone, although I like many HRPCa patients have

> high hopes for the drug!

> My Oncologist is recommending I try DES as a next step. He is

> open minded and will consider Estradiol patches but I'd like to

> provide information or studies that show one is better than the

> other.

> Any help would be appreciated!

> (BTW - I do have mets in my ribs, hips etc. but am currently

> not experiencing any pain related to these areas. Also, my Alk

> Phosphate level is normal (60) and have had several CTC tests

> that continue to come back at 0. T level has been below 10 for

> months. I will have updated T, PSA, CTC etc along with a bone

> scan on Friday)

,

I'm sorry to hear about the PSA rise. I had a friend who was

treated by Dr. " Snuffy " Myers with some a combination of

ketoconazole and estradiol (DES) patches and got a few months of

constant or lowered PSA from them, then tried leukine and

revlimid - a form of thalidomide. He had a good response to that

for some period of time. I don't remember how long. It might

have been six months or so. But he did have problems with anemia

I believe. Dr. Myers tried varying dosages, giving him smaller

doses more often, and that helped.

I believe that all of those drugs are approved by the FDA and

don't require entering a clinical trial in the U.S.

Some treatments only available in clinical trials include

MDV3100, and Alpharadin. Alpharadin is an injectable radioactive

isotope that has an affinity for growing bone tissue. It kills

cancer in the bones. Early results showed some benefits in both

pain relief and limited life extension. I don't know anything

about MDV3100, but understand it's being offered on a trial basis

to people who have failed chemotherapy.

For whatever it's worth, probably nothing, you might want to try

massive doses of over the counter supplements like pomegranate

extract and resveratrol. Dr. Myers also prescribed those for my

friend, though I don't think they did him much good.

One of the things about Dr. Myers' treatment that really

impressed me was that he tried just about everything that had

ever been shown to do any good in hopes that my friend would

respond to one of them. Ultimately, my friend died of PCa. But

I suspect he got an extra year from Dr. Myers that he wouldn't

have gotten with a more conventional specialist.

Best of luck. I hope something really works for you.

Alan

[Guest guest]

,

I have just uploaded a paper by Dr Premoli

– go to Files and page down – which might be of interest to you. His

e-mail address is fernandopremoli@...

All the best

Terry Herbert

I have no medical

qualifications but I was diagnosed in ‘96: and have learned a bit since

then.

My sites are at www.yananow.net and www.prostatecancerwatchfulwaiting.co.za

Dr

“Snuffy” Myers : " As a physician, I am painfully aware that most of

the decisions we make with regard to prostate cancer are made with inadequate

data "

From: ProstateCancerSupport [mailto:ProstateCancerSupport ] On Behalf Of Emerson

Sent: Thursday, 4 March 2010 4:37

AM

To: hrpca group; PCa Under Yahoo

Group; PPML List; Yahoo PCaGroup

Subject:

DES or Estradiol Patches

It looks

like it's time for me to make a change in my treatment.

My PSA from Monday went from 103 on 2/1 to 159 on 3/1

I am currently on HDK/HC and have already failed Casodex, Nilandron and a

previous

course of HDK/HC. Additionally, I did a 12 session Chemo round between

June 08 and Jan 09.

Currently I am not interested in a Phase III placebo controlled trial, such as

Abiraterone, although

I like many HRPCa patients have high hopes for the drug!

My Oncologist is recommending I try DES as a next step. He is open minded and

will consider

Estradiol patches but I'd like to provide information or studies that show one

is better than the other.

Any help would be appreciated!

(BTW - I do have mets in my ribs, hips etc. but am currently not experiencing

any pain related to these

areas. Also, my Alk Phosphate level is normal (60) and have had several CTC

tests that continue to come back at 0. T level has been below 10 for months. I

will have updated T, PSA, CTC etc along with a bone scan on Friday)

--

Emerson

www.flhw.org

[Guest guest]

I have done well on this, I take Clopidogrel alongside the DES 1mg to reduce chances of clotting.

DES or Estradiol Patches

It looks like it's time for me to make a change in my treatment. My PSA from Monday went from 103 on 2/1 to 159 on 3/1I am currently on HDK/HC and have already failed Casodex, Nilandron and a previouscourse of HDK/HC. Additionally, I did a 12 session Chemo round between June 08 and Jan 09.Currently I am not interested in a Phase III placebo controlled trial, such as Abiraterone, althoughI like many HRPCa patients have high hopes for the drug!My Oncologist is recommending I try DES as a next step. He is open minded and will consider Estradiol patches but I'd like to provide information or studies that show one is better than the other.Any help would be appreciated!(BTW - I do have mets in my ribs, hips etc. but am currently not experiencing any pain related to theseareas. Also, my Alk Phosphate level is normal (60) and have had several CTC tests that continue to come back at 0. T level has been below 10 for months. I will have updated T, PSA, CTC etc along with a bone scan on Friday)-- Emersonwww.flhw.org

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[Guest guest]

To: ProstateCancerSupport Sent: Wed, March 3, 2010 2:01:25 PMSubject: Re: DES or Estradiol Patches

Emerson <davidemerson@ flhw.org> wrote:> It looks like it's time for me to make a change in my> treatment. My PSA from Monday went from 103 on 2/1 to 159 on> 3/1> I am currently on HDK/HC and have already failed Casodex,> Nilandron and a previous course of HDK/HC. Additionally, I did> a 12 session Chemo round between June 08 and Jan 09. Currently> I am not interested in a Phase III placebo controlled trial,> such as Abiraterone, although I like many HRPCa patients have> high hopes for the drug!> My Oncologist is recommending I try DES as a next step. He is> open minded and will consider Estradiol patches but I'd like to> provide information or studies that show one is better than the> other.> Any help would be

appreciated!> (BTW - I do have mets in my ribs, hips etc. but am currently> not experiencing any pain related to these areas. Also, my Alk> Phosphate level is normal (60) and have had several CTC tests> that continue to come back at 0. T level has been below 10 for> months. I will have updated T, PSA, CTC etc along with a bone> scan on Friday),I'm sorry to hear about the PSA rise. I had a friend who wastreated by Dr. "Snuffy" Myers with some a combination ofketoconazole and estradiol (DES) patches and got a few months ofconstant or lowered PSA from them, then tried leukine andrevlimid - a form of thalidomide. He had a good response to thatfor some period of time. I don't remember how long. It mighthave been six months or so. But he did have problems with anemiaI believe. Dr. Myers tried varying dosages, giving him smallerdoses more often, and that

helped.I believe that all of those drugs are approved by the FDA anddon't require entering a clinical trial in the U.S.Some treatments only available in clinical trials includeMDV3100, and Alpharadin. Alpharadin is an injectable radioactiveisotope that has an affinity for growing bone tissue. It killscancer in the bones. Early results showed some benefits in bothpain relief and limited life extension. I don't know anythingabout MDV3100, but understand it's being offered on a trial basisto people who have failed chemotherapy.For whatever it's worth, probably nothing, you might want to trymassive doses of over the counter supplements like pomegranateextract and resveratrol. Dr. Myers also prescribed those for myfriend, though I don't think they did him much good.One of the things about Dr. Myers' treatment that reallyimpressed me was that he tried just about everything that

hadever been shown to do any good in hopes that my friend wouldrespond to one of them. Ultimately, my friend died of PCa. ButI suspect he got an extra year from Dr. Myers that he wouldn'thave gotten with a more conventional specialist.Best of luck. I hope something really works for you.Alan

I am not as knowledgeable as you guys are and I have looked up MDV3100. It looks very hopefull and seems to be used for other things so might be able to perscribe it even though not in trails. Again you guys have looked at this stuff for a long time. It looked really hopefull.

Tom W