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DES or Estradiol Patches

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It looks like it's time for me to make a change in my treatment. My PSA from Monday went from 103 on 2/1 to 159 on 3/1I am currently on HDK/HC and have already failed Casodex, Nilandron and a previouscourse of HDK/HC.  Additionally, I did a 12 session Chemo round between June 08 and Jan 09.

Currently I am not interested in a Phase III placebo controlled trial, such as Abiraterone, althoughI like many HRPCa patients have high hopes for the drug!My Oncologist is recommending I try DES as a next step. He is open minded and will consider

Estradiol patches but I'd like to provide information or studies that show one is better than the other.Any help would be appreciated!(BTW - I do have mets in my ribs, hips etc. but am currently not experiencing any pain related to these

areas. Also, my Alk Phosphate level is normal (60) and have had several CTC tests that continue to come back at 0. T level has been below 10 for months. I will have updated T, PSA, CTC etc along with a bone scan on Friday)

-- Emersonwww.flhw.org

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