UroToday - Beyond the Abstract - Prostate cancer mortality in screen and clinically detected prostate cancer: Estimating the screening benefit, by Pim J. van Leeuwen, MD

[Guest guest]

One of the possible methods of estimating the true effect of PSA screening

is the selection of a control population with a very low intensity of

screening. In Northern Ireland (NI), PSA screening is not recommended and there

is a well-documented low level of PSA testing (6% of men >50 years old).

Further, men tended not to proceed to prostate biopsy until PSA levels were

>10.0ng/ml, with few men with low PSA levels having a prostate biopsy. In

the current study, we compared the characteristics and outcomes of a population

participating in the ERSPC, section Rotterdam, with men in Northern Ireland

(NI) during a time period when asymptomatic PSA screening was infrequent.

Snip

Men undergoing systematic PSA screening had a 3.2 fold increased risk of being

diagnosed with PC. After 8.5 years, the rate of PC deaths was 37% lower in the

intervention population. In addition, 555 men needed to be screened and 37 men

needed treatment to prevent one PC-specific death.

http://www.urotoday.com/index.php?option=com_content & task=view_ua & id=2226454

[Guest guest]

Interesting one Kathy.

The death rate is especially interesting.

I always say it is not screening that is the problem, it is what is done when low grade PCa is found that needs understanding

UroToday - Beyond the Abstract - Prostate cancer mortality in screen and clinically detected prostate cancer: Estimating the screening benefit, by Pim J. van Leeuwen, MD

One of the possible methods of estimating the true effect of PSA screening is the selection of a control population with a very low intensity of screening. In Northern Ireland (NI), PSA screening is not recommended and there is a well-documented low level of PSA testing (6% of men >50 years old). Further, men tended not to proceed to prostate biopsy until PSA levels were >10.0ng/ml, with few men with low PSA levels having a prostate biopsy. In the current study, we compared the characteristics and outcomes of a population participating in the ERSPC, section Rotterdam, with men in Northern Ireland (NI) during a time period when asymptomatic PSA screening was infrequent.

Snip

Men undergoing systematic PSA screening had a 3.2 fold increased risk of being diagnosed with PC. After 8.5 years, the rate of PC deaths was 37% lower in the intervention population. In addition, 555 men needed to be screened and 37 men needed treatment to prevent one PC-specific death.

http://www.urotoday.com/index.php?option=com_content & task=view_ua & id=2226454

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