Casodex......was Prognosis

[Guest guest]

The situation with Casodex always

interests me. The major study of the effects of the drug were carried out in

countries all over the world – mainly so called Third World countries –

but not in the US.

I was fortunate enough to get a copy of the study when it was published from a

pal who was in the business. There were many aspects of the study that raised questions

as far as I was concerned and indeed there were others who had similar concerns

when we started discussing the study on the internet. An additional aspect in

the discussion was the fact that there had been somewhat of an expose about the

latitude given by the FDA to the changes in study results – manipulation of

data etc – and there was some suggestion that the Casodex data had been

spun somewhat to produce a better result and to minimize the side effects.

Who knows if this was so, if the points we

thought were valid were in fact valid, but it was interesting to see that the

FDA in the USA

only approved the 50 mg dose. What I found even more interesting was how

quickly this restriction was overcome by the patient being prescribed triple single

50 mg doses i.e 150 mg in all – the level that seemed troublesome in the

study, but the one adopted by Britain and, I think other countries in the

world.

So, what’s the right dose? I don’t

know – it has never made sense to me tat one dose should fit all

and the fact that the drug was tested in countries where the average size of

men is very much smaller than the average US man also casts some doubt on the

appropriate dose. I guess time might tell – but then again, maybe not.

All the best

Terry Herbert

I have no medical

qualifications but I was diagnosed in ‘96: and have learned a bit since

then.

My sites are at www.yananow.net and www.prostatecancerwatchfulwaiting.co.za

Dr

“Snuffy” Myers : " As a physician, I am painfully aware that most of

the decisions we make with regard to prostate cancer are made with inadequate

data "

From: ProstateCancerSupport [mailto:ProstateCancerSupport ] On Behalf Of Alan Meyer

Sent: Tuesday, 2 March 2010 9:25

AM

To: ProstateCancerSupport

Subject: Re:

Re: Prognosis

Metcalf <bryan.metcalfvirgin (DOT) net>

wrote:

>In the UK

we have used Casodex on its own.

>

>I used it for a number of years.

Right.

It's my understanding that it is not used on its own

in the U.S.

I don't know why practice would be different

in the two countries, but it is my understanding that

that is so.

Of course the person who can answer this question

for the patient in question is .

, was your brother also given an injection of Lupron,

Zoladex or Eligard? If not, then what I've said about

hormone therapy not working for him is wrong.

Alan