Re: PCA3 Test Shows Increased Specificity Compared To PSA

[Guest guest]

This is not new information regarding PCA3 BUT the significant issue, atleast to

me, is the the PCA3 test does NOt differentiate between PIN tissue (both HG and

LG) and cancerous tissue. Following two negative biopsies but a relatively high

PCA3, I tried as best I could to find any literature or knowledge on the

differentiation.

The best I could find was some inferred information in graphical results

indicating the PCA3 generation might be 3, or so, times as great in cancerous

tissue than in PIN tissue BUT both types of tissue generated PCA3 at far, far

higher rates than normal tissue. Therefore, a high PCA3 reading is to be

expected if one has multiple sites of PIN in their biopsies' cores, possibly

only from singular cores showing PIN. As a result, some doctors are disregarding

PCA3 results as much more than supplemental and likely not worth the cost. At

least that was another result my searches derived.

Admittedly, this information I cite is about a year old so additional

information may have come to light but I would be skeptical of relying on PCA3

as a cancer alarm.

Rich L

Green Bay, WI

>

> Click on the below link for the full story:

> <http://www.medicalnewstoday.com/articles/190631.php>

> A new urine test showed significant specificity when used to detect prostate

cancer, according to a new multi-institution study from researchers in Colorado,

Pennsylvania, New York and Virginia. Data on the new PCA3 urine test were

presented during the 105th Annual Scientific Meeting of the American Urological

Association (AUA). Crawford, MD, from the University of Colorado and

Prostate Conditions Education Council, and the principal investigator on the

study, states " these results will help develop a new paradigm for the early

detection of prostate cancer. "

>

[Guest guest]

I was rushed in for a biopsy after my PCA3 test went almost to the top of the

graph in the red zone. But it turned out that although my prostate was a mass

of high grade PIN, there was no cancer.

So I suppose the PCA3 test might help if the PSA rise is due to infection. But

it's certainly useless with HG PIN. All it did was to cause more worry, because

the PSA test had indicated that I needed a biopsy before I had the PCA3 test.

Ted

> >

> > Click on the below link for the full story:

> > <http://www.medicalnewstoday.com/articles/190631.php>

> > A new urine test showed significant specificity when used to detect prostate

cancer, according to a new multi-institution study from researchers in Colorado,

Pennsylvania, New York and Virginia. Data on the new PCA3 urine test were

presented during the 105th Annual Scientific Meeting of the American Urological

Association (AUA). Crawford, MD, from the University of Colorado and

Prostate Conditions Education Council, and the principal investigator on the

study, states " these results will help develop a new paradigm for the early

detection of prostate cancer. "

> >

>