Re: PROSTATE Digest - 28 Apr 2010 to 29 Apr 2010 - Special issue (#2010-284)

[Guest guest]

Anecdotally I and other PCa patients on Active Surveillance have noted

elevated PSA readings while having gum/tooth infections.

My latest was a PSA of 6.3 during a severe infection that resulted in a root

canal. Two months later the PSA was down to 5.2.

When consulting with Dr. Jabola at Loma in 2007 (while trying to

decide whether or not to treat, and , if so, how), he asked during his quite

thorough physical if I had chronic problems with bleeding gums. I had,

although not severe. He said his experience was this was not uncommon with

men diagnosed with prostate cancer.

Seems to be just another indication of the link between general inflammation

and at least indicators of cancer development.

The Best to You and Yours!

Jon in Nevada

-----------------------------------------------------------

Date: Thu, 29 Apr 2010 19:03:21 -0400

Subject: Are Periodontal Disease and Prostatitis Linked?

Are Periodontal Disease and Prostatitis Linked?

ScienceDaily (Apr. 28, 2010) — Researchers from Case Western Reserve

University School of Dental Medicine and University Hospitals Case Medical

Center report initial results from a small sample that inflammation from gum

disease and prostate problems just might be linked. They discuss their new

evidence in the Journal of Periodontology, the official journal of the

American Academy of Periodontology.

The researchers compared two markers: the prostate-specific antigen (PSA)

used to measure inflammation levels in prostate disease, and clinical

attachment level (CAL) of the gums and teeth, which can be an indicator for

periodontitis.

A PSA elevation of 4.0 ng/ml in the blood can be a sign of inflammation or

malignancy. Patients with healthy prostate glands have lower than 4.0ng/ml

levels. A CAL number greater than 2.7 mm indicates periodontitis.

Like prostatitis, periodontitis also produces high inflammation levels.

" Subjects with both high CAL levels and moderate to severe prostatitis have

higher levels of PSA or inflammation, " stated Nabil Bissada, chair of the

department of periodontics in the dental school.

Bissada added that this might explain why PSA levels can be high in

prostatitis, but sometimes cannot be explained by what is happening in the

prostate glands.

" It is something outside the prostate gland that is causing an inflammatory

reaction, " he said.

Because periodontitis has been linked to heart disease, diabetes and

rheumatoid arthritis, the researchers felt a link might exist to prostate

disease.

Thirty-five men from a sample of 150 patients qualified for the study,

funded by the department of periodontology at the dental school. The

participants were selected from patients at the University Hospitals Case

Medical Center with mild to severe prostatitis, who had undergone needle

biopsies and were found to have inflammation and in some patients,

malignancies.

The participants were divided into two groups: those with high PSA levels

for moderate or severe prostatitis or a malignancy and those with PSA levels

below 4 ng/ml. All had not had dental work done for at least three months

and were given an examination to measure the gum health.

Looking at the results, the researchers from the dental school and the

department of urology and the Institute of Pathology at the hospital found

those with the most severe form of the prostatitis also showed signs for

periodontitis.

Other authors on the paper, " Association between Periodontal Disease and

Prostate-Specific Antigen Levels in Chronic Prostatitis Patients, " were:

Nishant Joshi, Sena Narendran, Rick Jurevic and Skillicorn from the

CWRU dental school; and Bodner and T. MacLennon from the

University Hospitals Case Medical Center.

[Guest guest]

THANK YOU..and very interesting....what treatment did you elect to have done???

To: ProstateCancerSupport <ProstateCancerSupport >; ww ; PROSTATE Sent: Thu, April 29, 2010 8:06:17 PMSubject: Re: PROSTATE Digest - 28 Apr 2010 to 29 Apr 2010 - Special issue (#2010-284)

Anecdotally I and other PCa patients on Active Surveillance have noted elevated PSA readings while having gum/tooth infections.My latest was a PSA of 6.3 during a severe infection that resulted in a root canal. Two months later the PSA was down to 5.2.When consulting with Dr. Jabola at Loma in 2007 (while trying to decide whether or not to treat, and , if so, how), he asked during his quite thorough physical if I had chronic problems with bleeding gums. I had, although not severe. He said his experience was this was not uncommon with men diagnosed with prostate cancer.Seems to be just another indication of the link between general inflammation and at least indicators of cancer development.The Best to You and Yours!Jon in Nevada------------ --------- --------- --------- --------- --------- -Date: Thu, 29 Apr 2010 19:03:21 -0400Subject: Are Periodontal Disease and Prostatitis Linked?Are Periodontal Disease and Prostatitis Linked?ScienceDaily (Apr. 28, 2010) — Researchers from Case Western Reserve University School of Dental Medicine and University Hospitals Case Medical Center report initial results from a small sample that inflammation from gum disease and prostate problems just might be linked. They discuss their new evidence in the Journal of Periodontology, the official journal of the American Academy of Periodontology.The researchers compared two markers: the prostate-specific antigen (PSA) used to measure inflammation levels in prostate disease, and clinical attachment level (CAL) of the gums and teeth, which can be an indicator for periodontitis.A PSA elevation of 4.0 ng/ml in the blood can be a

sign of inflammation or malignancy. Patients with healthy prostate glands have lower than 4.0ng/ml levels. A CAL number greater than 2.7 mm indicates periodontitis.Like prostatitis, periodontitis also produces high inflammation levels."Subjects with both high CAL levels and moderate to severe prostatitis have higher levels of PSA or inflammation, " stated Nabil Bissada, chair of the department of periodontics in the dental school.Bissada added that this might explain why PSA levels can be high in prostatitis, but sometimes cannot be explained by what is happening in the prostate glands."It is something outside the prostate gland that is causing an inflammatory reaction," he said.Because periodontitis has been linked to heart disease, diabetes and rheumatoid arthritis, the researchers felt a link might exist to prostate disease.Thirty-five men from a sample of 150 patients qualified for the

study, funded by the department of periodontology at the dental school. The participants were selected from patients at the University Hospitals Case Medical Center with mild to severe prostatitis, who had undergone needle biopsies and were found to have inflammation and in some patients, malignancies.The participants were divided into two groups: those with high PSA levels for moderate or severe prostatitis or a malignancy and those with PSA levels below 4 ng/ml. All had not had dental work done for at least three months and were given an examination to measure the gum health.Looking at the results, the researchers from the dental school and the department of urology and the Institute of Pathology at the hospital found those with the most severe form of the prostatitis also showed signs for periodontitis.Other authors on the paper, "Association between Periodontal Disease and Prostate-Specific

Antigen Levels in Chronic Prostatitis Patients," were: Nishant Joshi, Sena Narendran, Rick Jurevic and Skillicorn from the CWRU dental school; and Bodner and T. MacLennon from the University Hospitals Case Medical Center.