Guest guest Posted March 14, 2010 Report Share Posted March 14, 2010 One of my observations over the years is that if I quote ‘awkward’ statistics that seem to point away from a cherished belief, I am told that there is no value in statistics, etc etc. On the other hand if there are statistics that support the status quo, they are regarded as genuine and acceptable. A case in point is the ruckus over the two large and contradictory studies concerning the value of screening. For anyone interested in the subject of the broad statistics of PCa, this report may be useful - http://caonline.amcancersoc.org/cgi/content/full/59/4/225#TBL7 There are a couple of points to highlight: 1. Figure 3 http://caonline.amcancersoc.org/content/vol59/issue4/images/large/CAAC20006fig003.jpeg shows how the incidence of PCa rocketed in the late 80s when PSA testing was introduced. It then fell (presumably because the first ‘sweeps’ had netted a large number of cases and started rising again until about 2002/3. It may be only coincidental that there was a significant change in the definition of PCa in 2002 when material graded as Gleason Grade 2 was no longer labelled as prostate cancer – and Gleason Score 5 diseases all but disappeared. 2. Figure 4 http://caonline.amcancersoc.org/content/vol59/issue4/images/large/CAAC20006fig004.jpeg shows how the mortality rate rose sharply in conjunction with the increased incidence and then started falling back to levels last seen in the 1950s. This graphs shows very clearly the enormous gap between the leading death dealing cancer - lung cancer – and prostate cancer. 3. Figure 9 http://caonline.amcancersoc.org/cgi/content/full/59/4/225/TBL9 shows the number of male deaths (1,201,942 in all) by the ten leading causes. Table 8 shows the number of prostate cancer deaths as 28,372 (4,000 less than in 1990), which is to say 2.36% of male deaths were from prostate cancer. If you look at the numbers of deaths in each of the top ten categories, you will see that the number of deaths from PCa is only a little higher than the number from suicide and influenza and way below causes such as heart failure (315,706 deaths), other cancers (261,697 deaths) and even accidents (78,941). The actual causes do, of course, vary with age but at every age there is a much greater chance of dying from something other than PCa – even for men diagnosed with the disease. Of course it is not possible for an individual to say that any populations statistic applies specifically to them. That is why it is important to gain a better understanding of how a dangerous, life threatening form of prostate cancer is defined, and how your own diagnosis compares to that definition. It is only then that you can start making a logical decision as to what is best for you as an individual and not to automatically assume that a definition of an early stage, very low risk cancer will lead to your death. It should be borne in mind that in terms of the new interpretation of Gleason Grades a score of 3+3=6 is the ‘entry level’ for a definition of PCa diagnosed from a needle biopsy. There is nothing lower. So, although 7a or 7b diagnoses (3+4=7 or 4+3=7) are more aggressive, they are only marginally so. I just wish every man should gain a better understanding of the various factors that go into a PCa diagnosis and the estimation of longevity and just where they fit in to those broad statistics before they make a decision that might not be in their best long term interests. All the best Prostate men need enlightening, not frightening Terry Herbert - diagnosed in 1996 and still going strong Read A Strange Place for unbiased information at http://www.yananow.net/StrangePlace/index.html Quote Link to comment Share on other sites More sharing options...
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