Re: Potential Treatments for HRPCa patients

[Guest guest]

this is great, just great. To wrestle with all of the information and then try to reduce it to an understandable table is the top post of this year.The keto issue is a tricky one. As an off-label treatment it may disqualify for many trials, in addition to the liver compromise it may create. I am aware that some men who are facing the keto decision may source the drug from outside of the US in order to determine if there is merit to the drug, while maintaining a "clean" medical record. The ethics there are questionable and I doubt many doctors would actively contribute to this charade. After answering a few related emails recently, I thought I would share this chart. If it doesn't post in the email correctly, I have also included a link to a Google Doc page. I don't make claim that this is either all inclusive, or 100% up to date. It is simply a tool we have used to keep track of all the options that are out there for HRPCa guys like myself. Comments are welcome. https://spreadsheets.google.com/pub?key=0AqRfsVaVAgMJdG42UHNVRElxNXRodVZJMjkyTXYwQUE & hl=en & output=html -- Emersonwww.flhw.orgEvery 2.25 minutes a man is diagnosed with prostate cancer. Every 16.5 minutes a man dies from the disease.~~~~~~~~~~~~~~~~~~~~~~~~~~~ Treatment Plus Delta Comments XL 184 * Taken orally * Clinical trial - logistics * Potential side effects minimal * Phase II * Limited but VERY encouraging results Provenge * Immunotherapy * Availability and logistics * Current results are showing improved survival benefits Abiraterone * Taken orally * Having taken Keto, excluded from most current trials * One of the more promising drugs * Potential lower PSA & tumor shrinkage * Phase I * Current phase I trial not for Keto naïve patients (NCT00910754) *Clinical trial in San - logistics MDV3100 * Results of clinical trials Phase I & II indicated encouraging results * Phase III (placebo) * Most frequent adverse side effect in Phase I & II trials was with limited negative side effects. fatigue. * Taken orally ARN-509 * NCT01171898 * Sloan Kettering Only * Phase I and II TAK-700 - Chemo exclusion http://clinicaltrials.gov/ct2/show/NCT01084655 Prostvac for use in patients whose disease has recurred after surgery or radiotherapy Alpharadin * Success in Phase I and II, moving to Phase III * Phase I * Specific for Pca with bone mets * At Sloan-Ketterning Only AEZS-108 * Phase I and II - USC, travel must stop Lurpon for a month or more http://clinicaltrials.gov/ct2/show/NCT01240629 Revlimid * Taken orally * Clinical trial locations: Baltimore, MD; Niles, IL * 21 days on, 7 off - repeat * Phase II * Per Dr. Van 1.5.09, Revlimid available off trial Rexin - G * Initial, limited studies promote favorable outcomes * No current trials in the US * Long shot at this point but initially looks promising * Commute to the Philippines!!! Mitoxantrone * Phase II * Chemo * Many locations including Wash U. St. Louis, MD , * Several studies with different combos Mayo Clinic * Typically combined with Prednisone Taxotere, Prednisone * Phase II * Chemo + Enzastaurin Taxotere, Prednisone * Chemo * Randomized trial + Bevacizumab *Targets new blood vessels Carboplatin * Phase II * Chemo * Per Dr. Van 1.5.09, treatment available @ KUCC, off trial * Combined with more Taxotere Thalidomide * Phase II * Chemo * Typically combined with Taxotere

[Guest guest]

thanks , I should have shared sooner.

I'll blame it on the medications!

 

this is great, just great. To wrestle with all of the information and then try to reduce it to an understandable table is the top post of this year.

The keto issue is a tricky one. As an off-label treatment it may disqualify for many trials, in addition to the liver compromise it may create. I am aware that some men who are facing the keto decision may source the drug from outside of the US in order to determine if there is merit to the drug, while maintaining a " clean " medical record. The ethics there are questionable and I doubt many doctors would actively contribute to this charade.

 

After answering a few related emails recently, I thought I would share this chart. If it doesn't post

in the email correctly, I have also included a link to a Google Doc page.

 

I don't make claim that this is either all inclusive, or 100% up to date. It is simply a tool we have used to keep track of all the options

that are out there for HRPCa guys like myself. Comments are welcome. 

https://spreadsheets.google.com/pub?key=0AqRfsVaVAgMJdG42UHNVRElxNXRodVZJMjkyTXYwQUE & hl=en & output=html

-- Emersonwww.flhw.orgEvery 2.25 minutes a man is diagnosed with prostate cancer.

Every 16.5 minutes a man dies from the disease.~~~~~~~~~~~~~~~~~~~~~~~~~~~

Treatment

Plus

Delta

Comments

XL 184

* Taken orally

* Clinical trial - logistics

 

 

* Potential side effects minimal

* Phase II

 

 

* Limited but VERY encouraging results

 

 

Provenge

* Immunotherapy 

* Availability and logistics

 

 

* Current results are showing improved survival benefits

 

 

 

 

 

 

Abiraterone

* Taken orally

* Having taken Keto, excluded from most current trials

* One of the more promising drugs

 

* Potential lower PSA & tumor shrinkage

* Phase I 

 

 

* Current phase I trial not for Keto naïve patients (NCT00910754)

*Clinical trial in San - logistics

 

MDV3100

* Results of clinical trials Phase I & II indicated encouraging results

* Phase III (placebo)

* Most frequent adverse side effect in Phase I & II trials was

 

with limited negative side effects.

 

fatigue.

 

* Taken orally

 

 

ARN-509

* NCT01171898

* Sloan Kettering Only

 

* Phase I and II

 

 

 

 

 

 

TAK-700

 

 

 - Chemo exclusion

 

http://clinicaltrials.gov/ct2/show/NCT01084655

 

 

 

 

 

 

Prostvac

for use in patients whose disease has recurred after surgery or radiotherapy 

 

 

 

 

 

 

 

 

Alpharadin

* Success in Phase I and II, moving to Phase III

* Phase I  

 

 

* Specific for Pca with bone mets

* At Sloan-Ketterning Only

 

 

 

 

 

AEZS-108

 

* Phase I and II

 - USC, travel

 

 

 

 must stop Lurpon for a month or more

 

http://clinicaltrials.gov/ct2/show/NCT01240629

 

 

Revlimid

* Taken orally

* Clinical trial locations: Baltimore, MD; Niles, IL

* 21 days on, 7 off - repeat

 

* Phase II

 

* Per Dr. Van 1.5.09, Revlimid available off trial 

 

 

 

 

Rexin - G

* Initial, limited studies promote favorable outcomes

* No current trials in the US

* Long shot at this point but initially looks promising

 

 

* Commute to the Philippines!!!

 

 

 

 

 

Mitoxantrone

* Phase II

* Chemo

* Many locations including Wash U. St. Louis, MD ,

 

* Several studies with different combos

 

Mayo Clinic

 

 

 

* Typically combined with Prednisone

Taxotere, Prednisone 

* Phase II

* Chemo

 

 + Enzastaurin

 

 

 

 

 

 

 

Taxotere, Prednisone 

 

* Chemo

* Randomized trial

 + Bevacizumab

 

 

*Targets new blood vessels

 

 

 

 

Carboplatin

* Phase II

* Chemo

* Per Dr. Van 1.5.09, treatment available @ KUCC, off trial

 

 

* Combined with more Taxotere

 

 

 

 

 

Thalidomide

* Phase II

* Chemo

 

 

 

* Typically combined with Taxotere

 

 

 

 

 

-- Emersonwww.flhw.org

Every 2.25 minutes a man is diagnosed with prostate cancer.Every 16.5 minutes a man dies from the disease.

[Guest guest]

Emerson wrote:

> After answering a few related emails recently, I thought I

> would share this chart.

....

For another useful source for this kind of information, in

addition to the excellent posting by , see this web page:

http://www.hrpca.org/index.htm

It's the home page for a website devoted to battling hormone

refractory prostate cancer.

There are links along the side of the page, including one to

" Proven treatments " and one to " Potential treatments " that will

be of interest to patients who are facing this issue.

Best of luck to all.

Alan