Potential Treatments for HRPCa patients

[Guest guest]

After answering a few related emails recently, I thought I would share this chart. If it doesn't post

in the email correctly, I have also included a link to a Google Doc page.

 

I don't make claim that this is either all inclusive, or 100% up to date. It is simply a tool we have used to keep track of all the options

that are out there for HRPCa guys like myself. Comments are welcome. 

https://spreadsheets.google.com/pub?key=0AqRfsVaVAgMJdG42UHNVRElxNXRodVZJMjkyTXYwQUE & hl=en & output=html

-- Emersonwww.flhw.orgEvery 2.25 minutes a man is diagnosed with prostate cancer.

Every 16.5 minutes a man dies from the disease.~~~~~~~~~~~~~~~~~~~~~~~~~~~

Treatment

Plus

Delta

Comments

XL 184

* Taken orally

* Clinical trial - logistics

 

 

* Potential side effects minimal

* Phase II

 

 

* Limited but VERY encouraging results

 

 

Provenge

* Immunotherapy 

* Availability and logistics

 

 

* Current results are showing improved survival benefits

 

 

 

 

 

 

Abiraterone

* Taken orally

* Having taken Keto, excluded from most current trials

* One of the more promising drugs

 

* Potential lower PSA & tumor shrinkage

* Phase I 

 

 

* Current phase I trial not for Keto naïve patients (NCT00910754)

*Clinical trial in San - logistics

 

MDV3100

* Results of clinical trials Phase I & II indicated encouraging results

* Phase III (placebo)

* Most frequent adverse side effect in Phase I & II trials was

 

with limited negative side effects.

 

fatigue.

 

* Taken orally

 

 

ARN-509

* NCT01171898

* Sloan Kettering Only

 

* Phase I and II

 

 

 

 

 

 

TAK-700

 

 

 - Chemo exclusion

 

http://clinicaltrials.gov/ct2/show/NCT01084655

 

 

 

 

 

 

Prostvac

for use in patients whose disease has recurred after surgery or radiotherapy 

 

 

 

 

 

 

 

 

Alpharadin

* Success in Phase I and II, moving to Phase III

* Phase I  

 

 

* Specific for Pca with bone mets

* At Sloan-Ketterning Only

 

 

 

 

 

AEZS-108

 

* Phase I and II

 - USC, travel

 

 

 

 must stop Lurpon for a month or more

 

http://clinicaltrials.gov/ct2/show/NCT01240629

 

 

Revlimid

* Taken orally

* Clinical trial locations: Baltimore, MD; Niles, IL

* 21 days on, 7 off - repeat

 

* Phase II

 

* Per Dr. Van 1.5.09, Revlimid available off trial 

 

 

 

 

Rexin - G

* Initial, limited studies promote favorable outcomes

* No current trials in the US

* Long shot at this point but initially looks promising

 

 

* Commute to the Philippines!!!

 

 

 

 

 

Mitoxantrone

* Phase II

* Chemo

* Many locations including Wash U. St. Louis, MD ,

 

* Several studies with different combos

 

Mayo Clinic

 

 

 

* Typically combined with Prednisone

Taxotere, Prednisone 

* Phase II

* Chemo

 

 + Enzastaurin

 

 

 

 

 

 

 

Taxotere, Prednisone 

 

* Chemo

* Randomized trial

 + Bevacizumab

 

 

*Targets new blood vessels

 

 

 

 

Carboplatin

* Phase II

* Chemo

* Per Dr. Van 1.5.09, treatment available @ KUCC, off trial

 

 

* Combined with more Taxotere

 

 

 

 

 

Thalidomide

* Phase II

* Chemo

 

 

 

* Typically combined with Taxotere