Guest guest Posted February 17, 2011 Report Share Posted February 17, 2011 Alan,I am not 100% sure, but I believe that Lupron Depot (as opposed to just Lupron) is actually an implant that is designed to be slowly released into the body fat. One of the things I've always wondered about with respect to ADT is how they make different doses work. Most drugs I know about have a " half-life " which is the period of time it takes for approximately half of the drug to be broken down in the body. For example, if the half life is 1 day, then if you take 10 mg of a drug, the next day half (5 mg) will be left. The day after, half of that will be left (2.5 mg), the day after that, half again (1.25 mg) and so on. I read recently that the half-life of Lupron is about 3 hours. So how do they get it to work for 30, 90, or 120 days with one injection? Do they inject a timed release formula? The idea would be to chemically bind the Lupron to another chemical that breaks down much more slowly, releasing small amounts of Lupron each day. Does the dose break down quickly, but it is such a large dose that it has a long-lasting effect for 30, 90, or whatever number of days? If anyone knows the answer, I'm very curious to hear it. Thanks. Alan -- T Nowak, MA, MSWDirector for Advocacy and Advanced Prostate Cancer Programs, Malecare Inc. Men Fighting Cancer, TogetherSurvivor - Recurrent Prostate, Thyroid, Melanoma and Renal Cancers www.advancedprostatecancer.net - A blog about advanced and recurrent prostate cancerwww.malecare.org - information and support about prostate cancer http://health.groups.yahoo.com/group/advancedprostatecancer/ - an online support group for men and their families diagnosed with advanced and recurrent prostate cancer Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 17, 2011 Report Share Posted February 17, 2011 -- Alan Meyer ameyer2@... > > >To: ProstateCancerSupport >Sent: Thu, February 17, 2011 8:45:02 PM >Subject: Re: Question about ADT > > > >Alan, >I am not 100% sure, but I believe that Lupron Depot (as opposed to just Lupron) >is actually an implant that is designed to be slowly released into the body >fat. I just found a sentence in the Wikipedia article on Leuprelin that says: " It is available as a slow-release implant or subcutaneous intramuscular injection. " Sounds to me like you're right. Alan Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 17, 2011 Report Share Posted February 17, 2011 Chuck Maack wrote: > Good place to pose your below questions, Alan, may be to > www.facebook.com/askdrmyers That sounds like a good suggestion but I've been avoiding Facebook. I joined it once and started getting bunches of " friend " requests from people I didn't know and other communications that I didn't want. I also kept reading about how Facebook publishes information that you imagine to be private and I saw how tricky it was to turn off invasive practices and how hard they made it to get off the system. I know that I've already posted so much stuff on the Internet that anyone who wants to can find out more about me than they can about their second cousins, but Facebook just didn't feel right. No doubt I will have to rejoin one day when the whole world stops communicating in any other way. But I'll try to hold off for a while longer. Alan Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 18, 2011 Report Share Posted February 18, 2011 This does not apply to prostate cancer, but I wanted to point out that when you get X-rays at the Dentist, ask them to use the collar that they get when buying the lead cover that they put on you to protect your genitals from the radiation. It protects your thyroid glands. Most dental practioners never use it. The thyroid is very sensitive to x-rays and it is a simple protection. Harry One of the things I've always wondered about with respect to ADTis how they make different doses work.Most drugs I know about have a "half-life" which is the period oftime it takes for approximately half of the drug to be brokendown in the body. For example, if the half life is 1 day, thenif you take 10 mg of a drug, the next day half (5 mg) will beleft. The day after, half of that will be left (2.5 mg), the dayafter that, half again (1.25 mg) and so on.I read recently that the half-life of Lupron is about 3 hours.So how do they get it to work for 30, 90, or 120 days with oneinjection?Do they inject a timed release formula? The idea would be tochemically bind the Lupron to another chemical that breaks downmuch more slowly, releasing small amounts of Lupron each day.Does the dose break down quickly, but it is such a large dosethat it has a long-lasting effect for 30, 90, or whatever numberof days?If anyone knows the answer, I'm very curious to hear it.Thanks.Alan -- T Nowak, MA, MSWDirector for Advocacy and Advanced Prostate Cancer Programs, Malecare Inc. Men Fighting Cancer, TogetherSurvivor - Recurrent Prostate, Thyroid, Melanoma and Renal Cancerswww.advancedprostatecancer.net - A blog about advanced and recurrent prostate cancerwww.malecare.org - information and support about prostate cancerhttp://health.groups.yahoo.com/group/advancedprostatecancer/ - an online support group for men and their families diagnosed with advanced and recurrent prostate cancer Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.