XL-184 update

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Thanks for the report .Everyone here is rooting for you. AlanTo: hrpca group <hrpca >; PCa Under Yahoo Group <prostatecancerunder50 >; PPML List ; Yahoo PCaGroup

<ProstateCancerSupport >Sent: Thursday, September 1, 2011 5:42 PMSubject: XL-184 Update

I went to Boston on Tuesday and started the trial (http://clinicaltrials.gov/ct2/show/NCT01347788?term=xl+184+and+prostate & rank=1)

This is the newly opened 25mg version of the Phase II trial.

My blood work, and CT scan from August 2nd were as expected; PSA 440, CT showed swollen lymph nodes in lower abdomen. Both

were known beforehand. The bone scan showed A LOT of new areas, it was a little frightening. I knew, I could feel all of this happening

over the weeks leading up to the scan but to see it on the monitor was a little shocking. (details at my blog is you want more)

Tuesday night and Wednesday I was exhausted, it was probably more from the 18 hour day than it was from the medication. I left my house at

4:40am and returned home at 10:45pm. Today I was less fatigued overall.

Initially, I haven't notice any side effects, but it has only been 48 hours. Side effect most commonly seen are:

- increased fatigue

- mild diarrhea

- callous like sores on hands and feet

I'll check in from time to time with updates, or check my blog, or email if I forget to update and your curious.

- Emersonwww.flhw.orgEvery 2.25 minutes a man is diagnosed with prostate cancer.

Every 16.5 minutes a man dies from the disease.

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Here is the link to the original poster for this drug, as described at a medical conference: http://www.exelixis.com/investors-media/press-releases?cpurl=http%3A%2F%2Fir.exelixis.com/phoenix.zhtml?c=120923%26p=irol-newsArticle%26ID=1530348%26highlight=Regards, T I went to Boston on Tuesday and started the trial (http://clinicaltrials.gov/ct2/show/NCT01347788?term=xl+184+and+prostate & rank=1)This is the newly opened 25mg version of the Phase II trial. My blood work, and CT scan from August 2nd were as expected; PSA 440, CT showed swollen lymph nodes in lower abdomen. Bothwere known beforehand. The bone scan showed A LOT of new areas, it was a little frightening. I knew, I could feel all of this happeningover the weeks leading up to the scan but to see it on the monitor was a little shocking. (details at my blog is you want more) Tuesday night and Wednesday I was exhausted, it was probably more from the 18 hour day than it was from the medication. I left my house at4:40am and returned home at 10:45pm. Today I was less fatigued overall. Initially, I haven't notice any side effects, but it has only been 48 hours. Side effect most commonly seen are:- increased fatigue- mild diarrhea- callous like sores on hands and feet I'll check in from time to time with updates, or check my blog, or email if I forget to update and your curious. - Emersonwww.flhw.orgEvery 2.25 minutes a man is diagnosed with prostate cancer.Every 16.5 minutes a man dies from the disease.

[Guest guest]

7 days in no side effects to report.

I have been off all Advil and pain pills for the last 48 hours!!

 

One of the lymph nodes in my neck (that has been enlarged for a while) now feels larger.

I have a call into the doc to discuss.-- Emersonwww.flhw.orgEvery 2.25 minutes a man is diagnosed with prostate cancer.

Every 16.5 minutes a man dies from the disease.