Re: XL 184 Update- Week 12

[Guest guest]

> After 12 weeks on Cabozantinib (XL 184) things are going OK.

....

> ... Also, after six days on the higher dose of the trial meds,

> the nausea was unbearable at times. ...

Thanks for the report .

When I think about what guys like you and many others on this

list go through I am filled with admiration for your ability to

take a calm and objective view of the process, and to share

information with the rest of us.

This is all probably stuff that you already know, but just in

case there's something new for you here, I suggest going to:

http://www.cancer.gov

and type " nausea " in the search box. Most of the documents

you'll see listed are are intended for patients. There are also

some links marked " health professional " that will give you

more technical information if you're interested.

For whatever it's worth, I always found music to be a useful

antidote for nausea. I think it helped to take my mind off my

stomach. Headphones are a way to listen without bothering anyone

else in the house. I suspect that anything distracting, like TV,

can be helpful. I have also used music when I'm nauseous and

trying to sleep.

Best of luck with your treatment. I hope the cancer keeps

regressing and the nasty side effects abate.

Alan

[Guest guest]

Thanks for the update. I find this useful. Hang in there Dave. Regards, T Poxon (proton beam therapy post 2.5 months + Lupron therapy) After 12 weeks on Cabozantinib (XL 184) things are going OK. I started the 25mg trial on August 30th. During the first 6 weeks I didn't notice any side effects, however I did notice anincrease in pain in several locations. On October 11 I had the first required follow up bone and CT scans. The results of thosescans showed a 20% improvement in the overall state of the bone mets. While good, the trial was looking for 30% or greater. On November 1st my dose was increased to 125mg (per the trial, I was concerned about that high of a dose). [side note I was at the time on both 2- 10mg Oxycontin and 6-8 325mg Oxycodone daily]. The increase in the trial drug coupled with the constant struggle with constipation from the pain meds, made for an interesting beginning on the month.After trying multiple OTC laxatives I finally got a prescription variety that stared working right away. Also, after six days on the higher dose of the trial meds, the nausea was unbearable at times. The doctor suggested I stop taking the medication for three days. With both the nausea and the constipation under control I started the trial meds again on November 10th at a lower 75mg dose.The following twelve days were spent readjusting the pain meds, laxatives etc and I was able to go back to Boston for my November 21st scans and doctor appointment on the 22nd. At the appointment on the 22nd the doctor showed me a side by side comparison of the October 11thand the November 21st bone scans. Even with my untrained eyes I could see a difference, and it was encouraging! There were a few spots thathad cleared up and most had noticeable reductions.75mg may still be too high, I still have occasional nausea issues. The best news is I have not had Oxycodone in almost 48 hours. Sleep is getting betterbut there are still some nights that are rough. Happy Holidays to all!-- Emersonwww.flhw.orgEvery 2.25 minutes a man is diagnosed with prostate cancer.Every 16.5 minutes a man dies from the disease.

[Guest guest]

The news is good for , and he is the pioneer for the rest of us. As has always been the case, pioneers collect more arrows than the rest of the troop.I am encouraged by this drug which appears to work for a significant majority of the candidates, albeit with dosage adjustments necessary. Many drugs at this stage are considered successful if 40-50% respond. I think a greater percentage is seen here. Again, a report from the future provided by Emerson. Thanks for the update. I find this useful. Hang in there Dave. Regards, T Poxon (proton beam therapy post 2.5 months + Lupron therapy) After 12 weeks on Cabozantinib (XL 184) things are going OK. I started the 25mg trial on August 30th. During the first 6 weeks I didn't notice any side effects, however I did notice anincrease in pain in several locations. On October 11 I had the first required follow up bone and CT scans. The results of thosescans showed a 20% improvement in the overall state of the bone mets. While good, the trial was looking for 30% or greater. On November 1st my dose was increased to 125mg (per the trial, I was concerned about that high of a dose). [side note I was at the time on both 2- 10mg Oxycontin and 6-8 325mg Oxycodone daily]. The increase in the trial drug coupled with the constant struggle with constipation from the pain meds, made for an interesting beginning on the month.After trying multiple OTC laxatives I finally got a prescription variety that stared working right away. Also, after six days on the higher dose of the trial meds, the nausea was unbearable at times. The doctor suggested I stop taking the medication for three days. With both the nausea and the constipation under control I started the trial meds again on November 10th at a lower 75mg dose.The following twelve days were spent readjusting the pain meds, laxatives etc and I was able to go back to Boston for my November 21st scans and doctor appointment on the 22nd. At the appointment on the 22nd the doctor showed me a side by side comparison of the October 11thand the November 21st bone scans. Even with my untrained eyes I could see a difference, and it was encouraging! There were a few spots thathad cleared up and most had noticeable reductions.75mg may still be too high, I still have occasional nausea issues. The best news is I have not had Oxycodone in almost 48 hours. Sleep is getting betterbut there are still some nights that are rough. Happy Holidays to all!-- Emersonwww.flhw.orgEvery 2.25 minutes a man is diagnosed with prostate cancer.Every 16.5 minutes a man dies from the disease.