Re: Positive Zytiga Results

[Guest guest]

Thank you for sharing your regimin and protocol. I will file this history away for the day when I may need it, too. Regards, T Poxon Positive Zytiga Results: In September 2010, after 14 years on/off/on/off androgen deprivation therapy, I completed my second intermittent androgen deprivation (IAD) that had lasted two months short of 6 years while “maintaining†with dutasteride/Avodart over that entire period. My PSA had finally reached the 2.0ng/ml plateau I had decided would be the appropriate time to return to adding bicalutamide (generic of Casodex) and Lupron to my continuing Avodart. With this return to ADT3 my PSA fluctuated down to as low as 1.67ng/ml by May 2011. However, despite this triple hormonal blockade, it then gradually began elevating and with the PSA level reaching 2.55ng/ml on September 2, 2011, I began abiraterone acetate/Zytiga 1000mg upon rising each morning (requires empty stomach) accompanied by Prednisone 5mg twice daily along with continuing Lupron and Avodart. In three weeks PSA dropped to 1.61ng/ml. At two months, PSA continued drop to 1.28ng/ml. On December 22nd, at a week short of four months, my PSA continued its drop to 0.74ng/ml. Testosterone has dropped to <3.0ng/dl (as we would expect with Zytiga effectiveness). All other CBC/CMP lab results at this time within normal ranges. CT imaging with and without contrast unable to identify location of any tumor activity though did determine osteopenia. A Circulating Tumor Cell (CTC) test determined zero cancer cells circulating in the blood stream. I am currently scheduled to continue this Zytiga protocol for a total 180 days (six 30-day prescriptions). Obviously pleased to be among those wherein Zytiga has proven to be effective. Chuck Always as close as the other end of your computer to help address any prostate cancer concerns. "What you leave behind is not what is engraved in stone monuments, but what is woven into the lives of others." (Chuck) Maack - Prostate Cancer Advocate/Activist Email: maack1@... PCa Help: "Observations" http://www.theprostateadvocate.com

[Guest guest]

Dear Chuck,

My heavens you have been through a lot.. I am so sorry,,,but I'm glad your PSA is going down and that there are no signs of cancer anywhere else and that the medications are working for you. And I hope it continues to do so. I just want to wish you the best and thank you for your advice. Happy Holidays and may your New Year be fun of fun, laughter and good health. I will keep you in my thoughts and prayers.

Best Wishes,

Sheila

To: advancedprostatecancer , ProstateCancerSupport , chb@...Sent: Friday, December 23, 2011 7:54:55 PMSubject: Positive Zytiga Results

Positive Zytiga Results:

In September 2010, after 14 years on/off/on/off androgen deprivation therapy, I completed my second intermittent androgen deprivation (IAD) that had lasted two months short of 6 years while “maintaining†with dutasteride/Avodart over that entire period. My PSA had finally reached the 2.0ng/ml plateau I had decided would be the appropriate time to return to adding bicalutamide (generic of Casodex) and Lupron to my continuing Avodart. With this return to ADT3 my PSA fluctuated down to as low as 1.67ng/ml by May 2011. However, despite this triple hormonal blockade, it then gradually began elevating and with the PSA level reaching 2.55ng/ml on September 2, 2011, I began abiraterone acetate/Zytiga 1000mg upon rising each morning (requires empty stomach) accompanied by Prednisone 5mg twice daily along with continuing Lupron and Avodart. In three weeks PSA dropped to 1.61ng/ml. At two months, PSA continued drop to 1.28ng/ml. On December 22nd, at a week short of four months, my PSA continued its drop to 0.74ng/ml. Testosterone has dropped to <3.0ng/dl (as we would expect with Zytiga effectiveness). All other CBC/CMP lab results at this time within normal ranges. CT imaging with and without contrast unable to identify location of any tumor activity though did determine osteopenia. A Circulating Tumor Cell (CTC) test determined zero cancer cells circulating in the blood stream. I am currently scheduled to continue this Zytiga protocol for a total 180 days (six 30-day prescriptions).

Obviously pleased to be among those wherein Zytiga has proven to be effective.

Chuck

Always as close as the other end of your computer to help address any prostate cancer concerns.

"What you leave behind is not what is engraved in stone monuments, but what is woven into the lives of others."

(Chuck) Maack - Prostate Cancer Advocate/Activist

Email: maack1@...

PCa Help: "Observations" http://www.theprostateadvocate.com

[Guest guest]

Merry Christmas and Happy Holidays to all. May the new year bring pleasure and accomplishments to you all. Regards, T Poxon Dear Chuck, My heavens you have been through a lot.. I am so sorry,,,but I'm glad your PSA is going down and that there are no signs of cancer anywhere else and that the medications are working for you. And I hope it continues to do so. I just want to wish you the best and thank you for your advice. Happy Holidays and may your New Year be fun of fun, laughter and good health. I will keep you in my thoughts and prayers. Best Wishes,SheilaTo: advancedprostatecancer , ProstateCancerSupport , chb@...Sent: Friday, December 23, 2011 7:54:55 PMSubject: Positive Zytiga Results Positive Zytiga Results: In September 2010, after 14 years on/off/on/off androgen deprivation therapy, I completed my second intermittent androgen deprivation (IAD) that had lasted two months short of 6 years while “maintaining†with dutasteride/Avodart over that entire period. My PSA had finally reached the 2.0ng/ml plateau I had decided would be the appropriate time to return to adding bicalutamide (generic of Casodex) and Lupron to my continuing Avodart. With this return to ADT3 my PSA fluctuated down to as low as 1.67ng/ml by May 2011. However, despite this triple hormonal blockade, it then gradually began elevating and with the PSA level reaching 2.55ng/ml on September 2, 2011, I began abiraterone acetate/Zytiga 1000mg upon rising each morning (requires empty stomach) accompanied by Prednisone 5mg twice daily along with continuing Lupron and Avodart. In three weeks PSA dropped to 1.61ng/ml. At two months, PSA continued drop to 1.28ng/ml. On December 22nd, at a week short of four months, my PSA continued its drop to 0.74ng/ml. Testosterone has dropped to <3.0ng/dl (as we would expect with Zytiga effectiveness). All other CBC/CMP lab results at this time within normal ranges. CT imaging with and without contrast unable to identify location of any tumor activity though did determine osteopenia. A Circulating Tumor Cell (CTC) test determined zero cancer cells circulating in the blood stream. I am currently scheduled to continue this Zytiga protocol for a total 180 days (six 30-day prescriptions). Obviously pleased to be among those wherein Zytiga has proven to be effective. Chuck Always as close as the other end of your computer to help address any prostate cancer concerns. "What you leave behind is not what is engraved in stone monuments, but what is woven into the lives of others." (Chuck) Maack - Prostate Cancer Advocate/Activist Email: maack1@... PCa Help: "Observations" http://www.theprostateadvocate.com

[Guest guest]

Thank you for your kind words, Sheila.  Much appreciated. Please note my recent reply to Jim Joliet on this forum to note that despite dealing with side effects of Zytiga, I am doing just fine and noticeably much better than so many others for whom we all pray. Chuck Always as close as the other end of your computer to help address any prostate cancer concerns. " What you leave behind is not what is engraved in stone monuments, but what is woven into the lives of others. " (Chuck) Maack - Prostate Cancer Advocate/Activist Email: maack1@... PCa Help: " Observations " http://www.theprostateadvocate.com From: ProstateCancerSupport [mailto:ProstateCancerSupport ] On Behalf Of shedorman@...Sent: Saturday, December 24, 2011 7:50 AMTo: ProstateCancerSupport Subject: Re: Positive Zytiga Results Dear Chuck, My heavens you have been through a lot.. I am so sorry,,,but I'm glad your PSA is going down and that there are no signs of cancer anywhere else and that the medications are working for you. And I hope it continues to do so. I just want to wish you the best and thank you for your advice. Happy Holidays and may your New Year be fun of fun, laughter and good health. I will keep you in my thoughts and prayers. Best Wishes,SheilaTo: advancedprostatecancer , ProstateCancerSupport , chb@...Sent: Friday, December 23, 2011 7:54:55 PMSubject: Positive Zytiga Results Positive Zytiga Results: In September 2010, after 14 years on/off/on/off androgen deprivation therapy, I completed my second intermittent androgen deprivation (IAD) that had lasted two months short of 6 years while “maintaining†with dutasteride/Avodart over that entire period. My PSA had finally reached the 2.0ng/ml plateau I had decided would be the appropriate time to return to adding bicalutamide (generic of Casodex) and Lupron to my continuing Avodart. With this return to ADT3 my PSA fluctuated down to as low as 1.67ng/ml by May 2011. However, despite this triple hormonal blockade, it then gradually began elevating and with the PSA level reaching 2.55ng/ml on September 2, 2011, I began abiraterone acetate/Zytiga 1000mg upon rising each morning (requires empty stomach) accompanied by Prednisone 5mg twice daily along with continuing Lupron and Avodart. In three weeks PSA dropped to 1.61ng/ml. At two months, PSA continued drop to 1.28ng/ml. On December 22nd, at a week short of four months, my PSA continued its drop to 0.74ng/ml. Testosterone has dropped to <3.0ng/dl (as we would expect with Zytiga effectiveness). All other CBC/CMP lab results at this time within normal ranges. CT imaging with and without contrast unable to identify location of any tumor activity though did determine osteopenia. A Circulating Tumor Cell (CTC) test determined zero cancer cells circulating in the blood stream. I am currently scheduled to continue this Zytiga protocol for a total 180 days (six 30-day prescriptions). Obviously pleased to be among those wherein Zytiga has proven to be effective. Chuck Always as close as the other end of your computer to help address any prostate cancer concerns. " What you leave behind is not what is engraved in stone monuments, but what is woven into the lives of others. " (Chuck) Maack - Prostate Cancer Advocate/Activist Email: maack1@... PCa Help: " Observations " http://www.theprostateadvocate.com

[Guest guest]

Positive Zytiga Results ...

Great news Chuck. I and everyone else in this group, and all of the many people

whom you have helped, will be thinking of you and wishing you the best in this

new treatment.

Alan

[Guest guest]

ChuckI join all the cheers that you are doing so well. Happy holidays T Nowak, M.A., M.S.W.Director of Advocacy & Advanced Prostate Cancer Programs

Positive Zytiga Results ...

Great news Chuck. I and everyone else in this group, and all of the many people whom you have helped, will be thinking of you and wishing you the best in this new treatment.

Alan