is there a way to know if your adt treatment is durable.

[Guest guest]

I amy now in my 9th month of triple blockade. At my last PSA test I achieved a

..005 reading. I am a gleason 4+5 and was wondering if there are any studies that

show if you attain a PSA that is undetectable how durable the response will be.

[Guest guest]

" rhome502@... " wrote:

> I am now in my 9th month of triple blockade. At my last PSA

> test I achieved a .005 reading. I am a gleason 4+5 and was

> wondering if there are any studies that show if you attain a

> PSA that is undetectable how durable the response will be.

I don't know the answer to your question.  However, I'm hopeful

that any answer you find will underestimate your actual survival

since the appearance of the new drugs, abiraterone/Zytiga and

MDV-3100/enzalutamide.

These new drugs have demonstrated that men who were thought to be

hormone refractory are generally not.  Their tumors have become

more sensitive to even tiny amounts of testosterone, and the new

drugs cut back testosterone uptake in the tumors much further so

that the tumors become quiescent again.

I recommend Chuck Maack's website as a good source for

information:

   http://www.theprostateadvocate.com/

Chuck was diagnosed with PCa 20 years ago, has been on hormone

therapy for most of that period, and has done a lot of research

on it.  He also posts frequently on this group and may have more

info for you.

Best of luck with your treatment.

    Alan

[Guest guest]

Alan Meyer wrote:

....

> Chuck was diagnosed with PCa 20 years ago, has been on hormone

> therapy for most of that period, and has done a lot of research

> on it.  He also posts frequently on this group and may have more

> info for you.

Besides being smart and knowledgeable, he's quick, getting in his

reply even before I could refer you to him

    Alan

[Guest guest]

Thank you Allan.

To: "ProstateCancerSupport " <ProstateCancerSupport >Sent: Mon, May 14, 2012 8:08:27 AMSubject: Re: is there a way to know if your adt treatment is durable.

Alan Meyer wrote:...> Chuck was diagnosed with PCa 20 years ago, has been on hormone> therapy for most of that period, and has done a lot of research> on it. He also posts frequently on this group and may have more> info for you.Besides being smart and knowledgeable, he's quick, getting in his reply even before I could refer you to him Alan

[Guest guest]

I don't think hormone therapy alone is curative. It only the to stops the growth of the cancer. Some times after having good PSA scores your Dr will give you a vacation from the hormones and that will ease some of your side effects. The vacation will last until your PSA starts to rise again and you will then receive another shot. You can live for quite a long time using this treatment and with any luck you will die from something else before your your cancer becomes hormone resistant and continues to grow even while you are receiving shots. Once that happens you will have to move on to another form of treatment. There are a lot of advances in this fieldSo what is occurring today may not be what you could receive eventually. As a side note hormone treatments work by halting the production of testosterone. After being under this therapy for a while your testes may atrophy and may no longer produce testosterone permanently. This is good in regards to your cancer but not so good for some of the side effects associated with hormone therapy. Sent from my iPhone

I amy now in my 9th month of triple blockade. At my last PSA test I achieved a .005 reading. I am a gleason 4+5 and was wondering if there are any studies that show if you attain a PSA that is undetectable how durable the response will be.

[Guest guest]

,As far as I know there are no very long term studies on this subject - there are very few long term studies onnany aspect of the disease. Over 1,100 men have shared their experiences with PCa on my site. You can search the data base to see if there is a "match" for your diagnosis. Doug story at http://www.yananow.org/display_story.php?id=288 may be of particular interest.All the best,TerrySent from my iPad

I amy now in my 9th month of triple blockade. At my last PSA test I achieved a .005 reading. I am a gleason 4+5 and was wondering if there are any studies that show if you attain a PSA that is undetectable how durable the response will be.

[Guest guest]

,

Here's my 2 cents worth. Diagnosed in April 2004 with Gleason 9 (4+5), I had 8 weeks of IMRT plus 15 months on Lupron+Casodex, then another 15 months on Lupron alone. No further treatments since Oct. of 2006. From that time to now my PSA has come back consistently in the 0.1 to 0.2 range. No sign of increasing. I'm happy with that!

Wishing you all the best,

Manny

Subject: is there a way to know if your adt treatment is durable.To: ProstateCancerSupport Date: Monday, May 14, 2012, 10:17 AM

I amy now in my 9th month of triple blockade. At my last PSA test I achieved a .005 reading. I am a gleason 4+5 and was wondering if there are any studies that show if you attain a PSA that is undetectable how durable the response will be.

[Guest guest]

I am glad to hear that since it is very close to the treatment I had. I started off with surgery and then they found out they didn’t get it all so it was IMRT and more hormones.  So far all of my PSA checks are in the undetectable range too. From: ProstateCancerSupport [mailto:ProstateCancerSupport ] On Behalf Of RosenbaumSent: Monday, May 14, 2012 10:11 PMTo: ProstateCancerSupport ; rhome502@...Subject: Re: is there a way to know if your adt treatment is durable. , Here's my 2 cents worth. Diagnosed in April 2004 with Gleason 9 (4+5), I had 8 weeks of IMRT plus 15 months on Lupron+Casodex, then another 15 months on Lupron alone. No further treatments since Oct. of 2006. From that time to now my PSA has come back consistently in the 0.1 to 0.2 range. No sign of increasing. I'm happy with that! Wishing you all the best, MannySubject: is there a way to know if your adt treatment is durable.To: ProstateCancerSupport Date: Monday, May 14, 2012, 10:17 AM I amy now in my 9th month of triple blockade. At my last PSA test I achieved a .005 reading. I am a gleason 4+5 and was wondering if there are any studies that show if you attain a PSA that is undetectable how durable the response will be.