Re: Lowering insulin treats prostate cancer

[Guest guest]

Henry,Been on HT since '07. Not a hint of Diabetes, so far. Can I pretty well expect it in the future?tdr To: Sent: Thursday, April 5, 2012 8:40 PM Subject: Lowering

insulin treats prostate cancer

Hi:The last thing I posted seemed to draw some attention. I wonder if this will ??This is an example of an old treatment that will never get off the ground. It's not new and it's a generic drug so the $$$ money to get it approved for cancer is slim and way off. However !! since most men on "hormone treatment are almost guaranteed to develop diabetes it might behove us to try

and get our primary physician to prescribe it. Metformin ---who Knew ???HenryCan a dirt-cheap diabetes drug fight cancer?By Anne Harding, Health.comupdated 4:23 PM EDT, Thu April 5, 2012Studies have found that metformin appears to slow or stop the growth of a wide range of cancer cells.STORY HIGHLIGHTSMetformin is now available in various

generic versions that cost just pennies per pillExtensive trials will be needed before the drug can be used as a standard cancer treatmentThe two-year survival rate was 30 % among the 117 patients taking metformin(Health.com) -- Each year billions of dollars are spent in the search to find new cancer drugs. Very few of these would-be treatments end up being approved by the government and entering widespread use, which makes it all the more intriguing that one of the most

promising new cancer drugs in years is, in fact, an old drug.Metformin, a diabetes drug, was approved by the Food and Drug Administration in 1995, and since then tens of millions of Americans with diabetes have taken it daily to control their blood sugar.The first hint that metformin might also have anticancer properties came a decade later, when two research teams separately reported that diabetes patients were less likely to develop cancer, and less likely to die from the disease, if they were taking the drug.This news wasn't entirely surprising: Metformin treats

diabetes in part by lowering insulin levels, and several types of cancer -- such as those of the breast, colon, and prostate -- have been linked to high levels of that hormone.But then, in 2006, researchers in Canada working with breast-cancer cells found that metformin increased the activity of an enzyme involved in tumor suppression, suggesting that the drug might fight cancer by working directly on cancer cells.Health.com: Know the warning

signs of type 2 diabetesThese two developments "set off a minor firestorm of interest," says Pamela Goodwin, M.D., a breast cancer researcher at the University of Toronto. "Basically there's been a convergence of all this information, and even before it was available we could see there was a strong signal here."Over the past several years, studies in cell cultures and animals have found that metformin appears to slow or stop the growth of a wide range of cancer cells, including those associated with breast, prostate, lung, and endometrial cancer.And the pace of research

has picked up. This week, at the annual meeting of the American Association for Cancer Research (AACR) in Chicago, researchers presented preliminary results from no fewer than 20 studies on metformin, including some in humans."I think certainly over the last two or three years that metformin has come to the fore, and people recognize that it has an important role to play," said , M.B.B.S., a staff medical oncologist at Princess Margaret Hospital, in Toronto, who presented new research at the

meeting.Health.com: 25 breast cancer myths bustedThe promising study findings aren't the only cause for enthusiasm among doctors. Metformin's decades-long history as a diabetes drug -- it entered the U.K. market back in 1958 -- suggests that it's generally safe.It's also extremely cheap. The U.S. patent on metformin expired in 2002, so the drug is now available in various generic versions that cost just pennies per pill.Extensive placebo-controlled clinical trials will be needed before metformin can

be used as a standard cancer treatment. While it's too soon to say how that research will play out, metformin's apparent versatility and low cost seems to offer unusual potential, says Pollak, M.D., director of cancer prevention at McGill University, in Montreal."This is not a cancer drug development story like any other," says Pollak, who led the 2006 study on metformin and enzymes. "It contrasts so much with what you hear in cancer research: doctors developing new targeted therapy that costs $800 a

month, and it works a little bit -- but only for certain kinds of patients with certain kinds of tumors.We don't very often see [that] the generic drug that's available at your drugstore anyways might have some use for cancer."Health.com: Prescription drugs that lead double livesThere may be a reason for that. Pharmaceutical companies that spend billions to develop patented -- and expensive -- cancer drugs have little incentive to fund or conduct studies on generics like metformin.As a result,

metformin researchers have struggled to scrape together the money needed for clinical trials, which can run into the millions. Many of the ongoing metformin studies around the world are "being done on a shoestring budget, in a sort of informal way," Pollak says."I imagine that if [metformin] was a proprietary drug owned by a major pharmaceutical company, they would be developing it very aggressively, because all of the indicators point in the same direction, and that's unusual," Goodwin says.Governments and nonprofit organizations have begun to fill the money gap. The National Cancer Institute (NCI), for instance, is funding dozens of clinical trials that are currently under way or recruiting patients.One of these studies, led by Goodwin, is exploring the effect of metformin on breast-cancer recurrence in 3,582 women. The other major funders for the trial are the Canadian Cancer Society and Apotex, a generic drug maker that has agreed to provide free metformin and placebo pills.Health.com: Simple things that may cut your breast cancer riskA recent shift in thinking at the National Institutes of Health (NIH), which includes the NCI, seems to be working in metformin's favor.In 2011, NIH director Francis , M.D., said that "drug rescue and repurposing" would be a major focus of the agency, with the goal of investigating new uses for already approved or abandoned drugs.A few days later, the agency's associate director for science policy, Amy , M.D., mentioned metformin as a prime example of this approach. Two-thirds of the NCI-funded clinical trials of metformin now under way were initiated in 2011 or later.The preliminary research in humans has been encouraging. At the AACR meeting, and his colleagues reported that cancer-cell growth seemed to slow in 22 men with prostate cancer who took metformin every day for three to four weeks before prostate cancer surgery. The study, however, did not include a placebo or control group."The drug has potential in early-stage prostate cancer," says. "My

job now is to work out the characteristics of the men who had the best response to the metformin so we can design appropriate studies."In another study, researchers from the University of Texas MD Cancer Center, in Houston, found that metformin was associated with better outcomes in diabetes patients with pancreatic cancer, an especially aggressive form of cancer.The two-year survival rate was 30 % among the 117 patients taking metformin and just 15% among 185 patients not on the drug.So far, most metformin research has focused on cancers related to obesity and

diabetes, like pancreatic cancer, Li says. But because metformin may stem cancer through several different channels -- by lowering insulin, directly slowing tumor growth, or promoting suicide by cancer cells -- it could potentially prove useful in many types of cancer.Health.com: 12 myths about insulin and type 2 diabetesThat possibility is a long ways from being confirmed, however, and in the meantime researchers investigating metformin

temper their optimism with caution. "It's not as fantastic as it sounds at first," Pollak says. "At first you see it and say, 'Half the cancers are gone -- let's put it in the drinking water.'"But the findings so far haven't shown that metformin directly reduces cancer risk or mortality in humans, Pollak adds. In studies such as Li's that have looked at cancer outcomes in diabetes patients, for instance, doctors may be prescribing metformin -- rather than insulin or other diabetes drugs -- only to their healthier

patients, who may be less likely to develop or die from cancer anyway.Moreover, even if some of metformin's anticancer effects are confirmed in humans, there's no guarantee the drug will become a useful treatment in real-world practice. "When we're dealing with patients, we have to always be aware that [metformin] possibly could not have clinical relevance," Goodwin says. "So we have to test it."

[Guest guest]

This relates to prostate cancer, breast cancer, arthritis, fibro-myalgia, high

blood pressure, and type 2 diabetes.

Dr. Cousens from Tree of Life has a wonderful program for supporting

people as they quickly reverse their type 2 diabetes.

This short clip gives an excellent overview, with enough details that one could

have similar success while working closely with a local physician and support.

I wanted to be sure to help spread the word. There is impressive healing power

in our food choices. People need the facts.

Know the options, hear the successes, and consider the power of our food

choices.

Peace, joy, and wellness,

M.

[Guest guest]

teresa wrote:

> Dr. Cousens from Tree of Life has a wonderful program

> for supporting people as they quickly reverse their type 2

> diabetes.  This short clip gives an excellent overview, with

> enough details that one could have similar success while

> working closely with a local physician and support.

>

I tried to watch this, but it seemed like total spam to me.  The

film contains zero information about diabetes.  It doesn't

explain what you can do to reduce your diabetes, it just urges

you to go to his three week program.  In other words, it's an

advertisement.

He implies that you can reverse your diabetes with diet but

doesn't really tell you how.  You have to go to his clinic and

pay him money to learn the secret.

He also uses all of the language and techniques of quackery.

Cousens throws out big words, sometimes inapproriately, as if

he's trying to impress rather than convey information.  He speaks

with a huge smile on his face like a benign messiah.

There are legitimate doctors who also do this kind of thing.

They practice medicine as a business and are willing to engage in

all sorts of advertising puffery.  Maybe Cousens is one of those,

or maybe he's just a run of the mill quack.  Either way, I

wouldn't trust him to treat a headache much less diabetes.

    Alan