Bayer, Algeta shares spike as FDA fast-tracks blockbuster hopeful

[Guest guest]

More good news for those of us with Metastatic disease

 

http://www.fiercebiotech.com/story/bayer-algeta-shares-spike-fda-fast-tracks-blockbuster-hopeful/2011-08-23

 

Emersonwww.flhw.orgEvery 2.25 minutes a man is diagnosed with prostate cancer.

Every 16.5 minutes a man dies from the disease.

[Guest guest]

Emerson wrote:

> More good news for those of us with Metastatic disease

    

http://www.fiercebiotech.com/story/bayer-algeta-shares-spike-fda-fast-tracks-blo\

ckbuster-hopeful/2011-08-23

As I understand it, alpharadin is a two-for-one sort of drug.  It

was originally developed to relieve bone pain and disability due

to bone metastases, which it apparently does.  However it turned

out that it also extended life for many patients.

Again, as I understand it, it contains a molecule that is

absorbed by growing bone bonded to a radioactive molecule.  Bones

that are growing due to metastatic cancer absorb the compound and

the radiation kills the cancer.

A pretty clever idea isn't it?

    Alan

[Guest guest]

You can go to the company website and read all about it. This is a company whose stock was selling for 15 dollars a share less than 2 years ago and last month was over 200 a share. I have seldom seen such a rise in price unless there was an overwhelming consensus that there was an imminent expectation of approval. Given Fast Track status by the FDA indicates that they want to get it on the market as soon as possible. It's important because there really isn't much for someone who's cancer has metastised to the bone. This may be a game changer. At least I am hopeful. Keep your fingers crossed.

BOB

----- Forwarded Message -----To: "ProstateCancerSupport " <ProstateCancerSupport >Sent: Tuesday, August 23, 2011 6:27 PMSubject: Re: Bayer, Algeta shares spike as FDA fast-tracks blockbuster hopeful

Emerson wrote:> More good news for those of us with Metastatic disease http://www.fiercebiotech.com/story/bayer-algeta-shares-spike-fda-fast-tracks-blockbuster-hopeful/2011-08-23As I understand it, alpharadin is a two-for-one sort of drug. Itwas originally developed to relieve bone pain and disability dueto bone metastases, which it apparently does. However it turnedout that it also extended life for many patients.Again, as I understand it, it contains a molecule that isabsorbed by growing bone bonded to a radioactive molecule. Bonesthat are growing due to

metastatic cancer absorb the compound andthe radiation kills the cancer.A pretty clever idea isn't it? Alan

[Guest guest]

Ran this by my onc today. He emailed it might work for me, but 'it would be awhile,' without indicating a time frame. Will try to nail it down at my next appointment.Was hoping it might stave off the need for chemo.tdrTo: "prostatecancersupport " <prostatecancersupport >Sent: Tuesday, August 23, 2011 8:56 PMSubject: Fw: Bayer, Algeta shares spike as FDA fast-tracks blockbuster hopeful

You can go to the company website and read all about it. This is a company whose stock was selling for 15 dollars a share less than 2 years ago and last month was over 200 a share. I have seldom seen such a rise in price unless there was an overwhelming consensus that there was an imminent expectation of approval. Given Fast Track status by the FDA indicates that they want to get it on the market as soon as possible. It's important because there really isn't much for someone who's cancer has metastised to the bone. This may be a game changer. At least I am hopeful. Keep your fingers crossed.

BOB

----- Forwarded Message -----To: "ProstateCancerSupport " <ProstateCancerSupport >Sent: Tuesday, August 23, 2011 6:27 PMSubject: Re: Bayer, Algeta shares spike as FDA fast-tracks blockbuster hopeful

Emerson wrote:> More good news for those of us with Metastatic disease http://www.fiercebiotech.com/story/bayer-algeta-shares-spike-fda-fast-tracks-blockbuster-hopeful/2011-08-23As I understand it, alpharadin is a two-for-one sort of drug. Itwas originally developed to relieve bone pain and disability dueto bone metastases, which it apparently does. However it turnedout that it also extended life for many patients.Again, as I understand it, it contains a molecule that isabsorbed by growing bone bonded to a radioactive molecule. Bonesthat are growing due

to

metastatic cancer absorb the compound andthe radiation kills the cancer.A pretty clever idea isn't it? Alan

[Guest guest]

Ran this by my onc today. He emailed it might work for me, but 'it would be awhile,' without indicating a time frame. Will try to nail it down at my next appointment.Was hoping it might stave off the need for chemo.tdrTo: "prostatecancersupport " <prostatecancersupport >Sent: Tuesday, August 23, 2011 8:56 PMSubject: Fw: Bayer, Algeta shares spike as FDA fast-tracks blockbuster hopeful

You can go to the company website and read all about it. This is a company whose stock was selling for 15 dollars a share less than 2 years ago and last month was over 200 a share. I have seldom seen such a rise in price unless there was an overwhelming consensus that there was an imminent expectation of approval. Given Fast Track status by the FDA indicates that they want to get it on the market as soon as possible. It's important because there really isn't much for someone who's cancer has metastised to the bone. This may be a game changer. At least I am hopeful. Keep your fingers crossed.

BOB

----- Forwarded Message -----To: "ProstateCancerSupport " <ProstateCancerSupport >Sent: Tuesday, August 23, 2011 6:27 PMSubject: Re: Bayer, Algeta shares spike as FDA fast-tracks blockbuster hopeful

Emerson wrote:> More good news for those of us with Metastatic disease http://www.fiercebiotech.com/story/bayer-algeta-shares-spike-fda-fast-tracks-blockbuster-hopeful/2011-08-23As I understand it, alpharadin is a two-for-one sort of drug. Itwas originally developed to relieve bone pain and disability dueto bone metastases, which it apparently does. However it turnedout that it also extended life for many patients.Again, as I understand it, it contains a molecule that isabsorbed by growing bone bonded to a radioactive molecule. Bonesthat are growing due

to

metastatic cancer absorb the compound andthe radiation kills the cancer.A pretty clever idea isn't it? Alan

[Guest guest]

Go to the website of the company and to the Clinicaltrials.gov page and see if they are still recruiting, or, if they are near the end of the trial. Since it's going to be fast tracked I think it will be here sooner rather than later. But if you go to their website you may be able to get a general time line. You can also e-mail the company and ask questions or call them on the phone if you like. Just pay attention to the time zones. Norweigians like most Scandinavians speak reasonably good English as it's taught in the schools as a second language. No one outside of Norway who isn't of Norwegian decent speaks Norwegian and they don't expect you to so don't feel embarressed by a language barrier. Actually, they like to speak

English, it's good practice for them and they don't mind. I worked with quite of few of them in the technical field years ago with communications systems.

BOB

----- Forwarded Message -----To: "ProstateCancerSupport " <ProstateCancerSupport >Sent: Wednesday, August 24, 2011 1:41 AMSubject: Re: Bayer, Algeta shares spike as FDA fast-tracks blockbuster hopeful

Ran this by my onc today. He emailed it might work for me, but 'it would be awhile,' without indicating a time frame. Will try to nail it down at my next appointment.

Was hoping it might stave off the need for chemo.

tdr

To: "prostatecancersupport " <prostatecancersupport >Sent: Tuesday, August 23, 2011 8:56 PMSubject: Fw: Bayer, Algeta shares spike as FDA fast-tracks blockbuster hopeful

You can go to the company website and read all about it. This is a company whose stock was selling for 15 dollars a share less than 2 years ago and last month was over 200 a share. I have seldom seen such a rise in price unless there was an overwhelming consensus that there was an imminent expectation of approval. Given Fast Track status by the FDA indicates that they want to get it on the market as soon as possible. It's important because there really isn't much for someone who's cancer has metastised to the bone. This may be a game changer. At least I am hopeful. Keep your fingers crossed.

BOB

----- Forwarded Message -----To: "ProstateCancerSupport " <ProstateCancerSupport >Sent: Tuesday, August 23, 2011 6:27 PMSubject: Re: Bayer, Algeta shares spike as FDA fast-tracks blockbuster hopeful

Emerson wrote:> More good news for those of us with Metastatic disease http://www.fiercebiotech.com/story/bayer-algeta-shares-spike-fda-fast-tracks-blockbuster-hopeful/2011-08-23As I understand it, alpharadin is a two-for-one sort of drug. Itwas originally developed to relieve bone pain and disability dueto bone metastases, which it apparently does. However it turnedout that it also extended life for many patients.Again, as I understand it, it contains a molecule that isabsorbed by growing bone bonded to a radioactive molecule. Bonesthat are growing due to

metastatic cancer absorb the compound andthe radiation kills the cancer.A pretty clever idea isn't it? Alan

[Guest guest]

Go to the website of the company and to the Clinicaltrials.gov page and see if they are still recruiting, or, if they are near the end of the trial. Since it's going to be fast tracked I think it will be here sooner rather than later. But if you go to their website you may be able to get a general time line. You can also e-mail the company and ask questions or call them on the phone if you like. Just pay attention to the time zones. Norweigians like most Scandinavians speak reasonably good English as it's taught in the schools as a second language. No one outside of Norway who isn't of Norwegian decent speaks Norwegian and they don't expect you to so don't feel embarressed by a language barrier. Actually, they like to speak

English, it's good practice for them and they don't mind. I worked with quite of few of them in the technical field years ago with communications systems.

BOB

----- Forwarded Message -----To: "ProstateCancerSupport " <ProstateCancerSupport >Sent: Wednesday, August 24, 2011 1:41 AMSubject: Re: Bayer, Algeta shares spike as FDA fast-tracks blockbuster hopeful

Ran this by my onc today. He emailed it might work for me, but 'it would be awhile,' without indicating a time frame. Will try to nail it down at my next appointment.

Was hoping it might stave off the need for chemo.

tdr

To: "prostatecancersupport " <prostatecancersupport >Sent: Tuesday, August 23, 2011 8:56 PMSubject: Fw: Bayer, Algeta shares spike as FDA fast-tracks blockbuster hopeful

You can go to the company website and read all about it. This is a company whose stock was selling for 15 dollars a share less than 2 years ago and last month was over 200 a share. I have seldom seen such a rise in price unless there was an overwhelming consensus that there was an imminent expectation of approval. Given Fast Track status by the FDA indicates that they want to get it on the market as soon as possible. It's important because there really isn't much for someone who's cancer has metastised to the bone. This may be a game changer. At least I am hopeful. Keep your fingers crossed.

BOB

----- Forwarded Message -----To: "ProstateCancerSupport " <ProstateCancerSupport >Sent: Tuesday, August 23, 2011 6:27 PMSubject: Re: Bayer, Algeta shares spike as FDA fast-tracks blockbuster hopeful

Emerson wrote:> More good news for those of us with Metastatic disease http://www.fiercebiotech.com/story/bayer-algeta-shares-spike-fda-fast-tracks-blockbuster-hopeful/2011-08-23As I understand it, alpharadin is a two-for-one sort of drug. Itwas originally developed to relieve bone pain and disability dueto bone metastases, which it apparently does. However it turnedout that it also extended life for many patients.Again, as I understand it, it contains a molecule that isabsorbed by growing bone bonded to a radioactive molecule. Bonesthat are growing due to

metastatic cancer absorb the compound andthe radiation kills the cancer.A pretty clever idea isn't it? Alan

[Guest guest]

TD Roebling wrote:

> Ran this by my onc today.  He emailed it might work for me, but

> 'it would be awhile,' without indicating a time frame.  Will

> try to nail it down at my next appointment.

> Was hoping it might stave off the need for chemo.

As I understand it, the benefit a patient gets from Alpharadin

will depend on the nature of his metastases.  If they're mainly

in the bones, the patient can get a lot of benefit.  If they're

in the soft tissues - brain, heart, liver, lungs, etc. there may

be no benefit at all.

If and when the drug becomes available, I'm wondering if a full

body scan, e.g., with MRI, might tell whether a patient can

benefit without having to just take the drug.

Some patients will have metastases both in the bones and in a

vital organ.  In that case the metastasis in the vital organ will

kill the patient whether or not he takes Alpharadin.  But it

might still be worth taking the drug if he has significant bone

pain.

    Alan

[Guest guest]

TD Roebling wrote:

> Ran this by my onc today.  He emailed it might work for me, but

> 'it would be awhile,' without indicating a time frame.  Will

> try to nail it down at my next appointment.

> Was hoping it might stave off the need for chemo.

As I understand it, the benefit a patient gets from Alpharadin

will depend on the nature of his metastases.  If they're mainly

in the bones, the patient can get a lot of benefit.  If they're

in the soft tissues - brain, heart, liver, lungs, etc. there may

be no benefit at all.

If and when the drug becomes available, I'm wondering if a full

body scan, e.g., with MRI, might tell whether a patient can

benefit without having to just take the drug.

Some patients will have metastases both in the bones and in a

vital organ.  In that case the metastasis in the vital organ will

kill the patient whether or not he takes Alpharadin.  But it

might still be worth taking the drug if he has significant bone

pain.

    Alan

[Guest guest]

wrote:

> Go to the website of the company and to the Clinicaltrials.gov

> page and see if they are still recruiting, ...

Good advice.

Also, TD, you might ask your doctor about Abiraterone.  It's now

approved.

    Alan

[Guest guest]

Alan,As you suggest, will check out the clinical trials.Abiraterone's in my rear-view mirror. Worked well for thirteen months,without any side affects.tdrTo: "ProstateCancerSupport " <ProstateCancerSupport >Sent: Tuesday, August 23, 2011 11:12 PMSubject: Re: Bayer, Algeta shares spike as FDA fast-tracks blockbuster hopeful

wrote:

> Go to the website of the company and to the Clinicaltrials.gov

> page and see if they are still recruiting, ...

Good advice.

Also, TD, you might ask your doctor about Abiraterone. It's now

approved.

Alan

[Guest guest]

Alan,As you suggest, will check out the clinical trials.Abiraterone's in my rear-view mirror. Worked well for thirteen months,without any side affects.tdrTo: "ProstateCancerSupport " <ProstateCancerSupport >Sent: Tuesday, August 23, 2011 11:12 PMSubject: Re: Bayer, Algeta shares spike as FDA fast-tracks blockbuster hopeful

wrote:

> Go to the website of the company and to the Clinicaltrials.gov

> page and see if they are still recruiting, ...

Good advice.

Also, TD, you might ask your doctor about Abiraterone. It's now

approved.

Alan

[Guest guest]

Alan,Had two painless mets close by on a T7 rib and the spine radiated four months ago. A scan a month later revealed no growth or reduction. The doctor said it can take as long as a year to see radiation benefit.At my DX in '07, pelvic lymph node mets were discovered; also on seminal vessels, the neck of the bladder, and two on the bladder wall (which are being monitored closely, to decide when and how they should be shaved) No other soft-tissue mets.tdrTo: "ProstateCancerSupport " <ProstateCancerSupport >Sent: Tuesday, August 23, 2011 11:09 PMSubject: Re: Bayer, Algeta shares spike as FDA fast-tracks blockbuster hopeful

TD Roebling wrote:

> Ran this by my onc today. He emailed it might work for me, but

> 'it would be awhile,' without indicating a time frame. Will

> try to nail it down at my next appointment.

> Was hoping it might stave off the need for chemo.

As I understand it, the benefit a patient gets from Alpharadin

will depend on the nature of his metastases. If they're mainly

in the bones, the patient can get a lot of benefit. If they're

in the soft tissues - brain, heart, liver, lungs, etc. there may

be no benefit at all.

If and when the drug becomes available, I'm wondering if a full

body scan, e.g., with MRI, might tell whether a patient can

benefit without having to just take the drug.

Some patients will have metastases both in the bones and in a

vital organ. In that case the metastasis in the vital organ will

kill the patient whether or not he takes Alpharadin. But it

might still be worth taking the drug if he has significant bone

pain.

Alan

[Guest guest]

Alan,Had two painless mets close by on a T7 rib and the spine radiated four months ago. A scan a month later revealed no growth or reduction. The doctor said it can take as long as a year to see radiation benefit.At my DX in '07, pelvic lymph node mets were discovered; also on seminal vessels, the neck of the bladder, and two on the bladder wall (which are being monitored closely, to decide when and how they should be shaved) No other soft-tissue mets.tdrTo: "ProstateCancerSupport " <ProstateCancerSupport >Sent: Tuesday, August 23, 2011 11:09 PMSubject: Re: Bayer, Algeta shares spike as FDA fast-tracks blockbuster hopeful

TD Roebling wrote:

> Ran this by my onc today. He emailed it might work for me, but

> 'it would be awhile,' without indicating a time frame. Will

> try to nail it down at my next appointment.

> Was hoping it might stave off the need for chemo.

As I understand it, the benefit a patient gets from Alpharadin

will depend on the nature of his metastases. If they're mainly

in the bones, the patient can get a lot of benefit. If they're

in the soft tissues - brain, heart, liver, lungs, etc. there may

be no benefit at all.

If and when the drug becomes available, I'm wondering if a full

body scan, e.g., with MRI, might tell whether a patient can

benefit without having to just take the drug.

Some patients will have metastases both in the bones and in a

vital organ. In that case the metastasis in the vital organ will

kill the patient whether or not he takes Alpharadin. But it

might still be worth taking the drug if he has significant bone

pain.

Alan