Fw: Big News for Prostate Cancer Treatment

[Guest guest]

I hope you will keep us informed Ralph. I've been following the company on the internet. It sounds very promising. I'm praying for you. Best of luck. BOB

----- Forwarded Message -----To: "ProstateCancerSupport " <ProstateCancerSupport >Sent: Friday, August 26, 2011 2:10 PMSubject: Re: Big News for Prostate Cancer Treatment

I start clinical trial next Wed.

To: ProstateCancerSupport Sent: Thursday, August 25, 2011 1:51 PMSubject: Big News for Prostate Cancer Treatment

Has everyone heard about this?

There is a new drug in town from Exelixis called XL184 (cabozantinib) which was reported on in three big presentations at this year’s American Society of Clinical Oncology meeting in Chicago.

In ongoing Phase II clinical trials, XL184 has unprecedented activity in prostate cancer. It is also active in other cancers. Seattle Cancer Care Alliance has the Phase II XL184 trial open for prostate cancer patients now and will open it for ovarian cancer patients in the near future.

The excitement around this drug comes from its ability to cause regressions in bone scans—bone metastases unlike anything ever seen before. It also seems to be shrinking metastatic tumors in other sites.

“Until recently, no compound has resulted in marked improvements in bone metastases as measured by bone scans in advanced metastatic castrate resistant prostate cancer (mCRPC),†says Dr. Celestia Higano, medical oncologist at SCCA. “However, recent data with cabozantinib have shown marked effects on bone lesions on bone scan paired with alleviation of bone pain as well as shrinkage of measurable tumor lesions. Bone pain alleviation, supported by bone scan response assessment, may provide a possible endpoint for this compound that effectively addresses a clinically relevant, unmet medical need in men with prostate cancer.â€

Sounds exciting!

Bob