Guest guest Posted June 14, 2011 Report Share Posted June 14, 2011 1) If the 5 ARI study was going well, and the drug company was confident of long term advantage, of course they would have kept the trial going. This is just common sense. 2) There is a theoretical mechanism whereby 5 ARIs make PCa worse. They block 3b-adiol. Research regarding the benefits of adequate 3β-adiol is growing. 3β-adiol is an androgen that stimulates only estrogen receptor beta, which has anti-proliferative and re-differentiation activities. . Among other functions, estrogen receptor beta helps regulate prostate growth and differentiation.13,14,15,16 It is also an important modulator of the stress response in the brain.17,18Over-inhibition of 5-alpha reductase can result in under-stimulation of estrogen receptor beta, changing the balance of proliferative/anti-proliferative activity in the prostate as well as elsewhere. http://meridianvalleylab.com/5-alpha-reductase-over-inhibition/ Doug Quote Link to comment Share on other sites More sharing options...
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