Guest guest Posted August 27, 1999 Report Share Posted August 27, 1999 In article <3.0.5.32.19990826205555.00890480@...>, Joyce <hiattruc@...> writes >From: Joyce <hiattruc@...> > >> >>I was on the AP (50 mgs. and increased to 200 mgs 3 x weekly) November >1997 til Jan.1999. Many problems developed and in March, my MD and rheumy >decided that I have developed a Minocin hypersensitivity. Many problems >have contined. Today i was told that The ANA shows a definite positive. >Over the past 10 RA years many ANA tests have been done and have always >been negative. >> >>If this is Minocin induced Lupus, is it lifelong or will it go away since >I've discontinued the Minocin (in March 99) >> >>Thank you Dr. Chiu. >> >>Joyce Lupus is not just a positive ANA. Many patients with RA have a positive ANA, and many go on to develop an ANA with time. Drug induced diseases usually disappear with withdrawing the drug, so I would suspect that it is unrelated. Furthermore, labs can do different types of ANA tests - one lab can be negative, and on the same day, another lab using a different technique can be positive. ( That's my experience locally. ) Doesn't instil much confidence does it! ------- Regards, Dr Graham Chiu Prospective Internet Observational Study in Arthritis Home Page http://www.compkarori.com/arthritis/ Contribute at http://www.compkarori.com/arthritis/contrib.htm Data Entry at http://www.compkarori.com/cgi-local/piosa.cgi Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 27, 1999 Report Share Posted August 27, 1999 Dr Graham Chiu wrote: > > Furthermore, labs can do different types of ANA tests - one lab can be > negative, and on the same day, another lab using a different technique > can be positive. ( That's my experience locally. ) > > Doesn't instil much confidence does it! Just goes to show that medicine is still very much an " art " , not just chemistry. -- Geoff Crenshaw ----------------------- Captain Cook's Cruise Center ** Usual Disclaimers ** ----------------------- Religion: Man's attempt to discover God Christianity: God's offer to save humankind Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 26, 1999 Report Share Posted November 26, 1999 In article <943592163.14532onelist>, rhonda@... writes >From: rhonda@... > >In Toronto, scientists recently announced they had discovered a molecule in the >body that blocks the substance that destroys joints. They said the destructive >substance is produced by the T-cells. >But now in Boston, scientists announced the problem is caused by an enzyme found >throughout the body. >And Dr. Brown believed rheumatic diseases are caused by mycoplasma. Just >wondered what your opinion is, Dr. Chiu. Could it be all of the above? >Thanks, >Rhonda > There's no contradiction. Presumably this enzyme is activated in the inflammatory process that is part of the response to the infection. Still doesn't cure the disease, and we don't know if there will be side effects from blocking this enzyme. Blocking TNF alpha was thought to be a great idea - Enbrel works this way. However, I'm told that the newer Enbrel like agents have a disturbing ability to reactivate old tuberculosis. ------- Regards, Dr Graham Chiu Munching on some unexpected organics that arrived in the mail. So that's what Thanksgiving is all about! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 20, 1999 Report Share Posted December 20, 1999 In article <945624834.15859onelist>, rhonda@... writes >From: rhonda@... > >Dr. Chiu: >In your recent post to Mason you said you prefer two antibiotics to one. >I am taking Minocin and am preparing to add either Zithromax or Biaxin. Any >suggestions on which I should try? >Thank you, >Rhonda My current choice is Biaxin, but that's based upon my local experience. ------- Regards, Dr Graham Chiu Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 20, 1999 Report Share Posted December 20, 1999 Hi, I am wondering if Dr. Chiu could tell me more about doubling the antibiotics. I am currently taking 100 mg. per day of doryx (doxi). I was taking 200 mg. per day but it made my pain so bad for over a year. If I were to add biaxin or cipro or zithromax, would I take less of the doryx, and what would be they typical dosage of the added drug. It is important for me to know this since my doctor is willing to go along with me, but knows nothing about what antibiotics and what dosages to give. I was doing great on minocycline for over a year, but I had to quit it because of hyperpigmentation. Since switching to doxy, I have had further damage to joints along with major pain. Thank you, Gloria Tate RA 15 years, AP 3 years ___________________________________________________________________ Why pay more to get Web access? Try Juno for FREE -- then it's just $9.95/month if you act NOW! Get your free software today: http://dl.www.juno.com/dynoget/tagj. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 1, 2000 Report Share Posted January 1, 2000 In article <00df01bf546e$5f2bb960$7a00f9d8@ken-greason>, Ken and <kglg@...> writes >AP, methotrexate had also stopped having any effect. How does this fit in >with the theory that most damage occurs within the first two years? Am I an >exception to the rule? It's not a theory, more of an observation. And since RA is a polymorphic disease, then there will always be variations. I have met quite a few patients who have been well controlled for years who for unknown reasons develop uncontrolled disease when the erosions develop. ------- Regards, Dr Graham Chiu Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 24, 2000 Report Share Posted January 24, 2000 Dr. Chiu, I am currently on metho and minocycline. I noticed this note at www.rxlist.com and wondered what you thought of this? Should I be concerned about this? " Oral antibiotics such as tetracycline, chloramphenicol, and nonabsorbable broad spectrum antibiotics, may decrease intestinal absorption of methotrexate or interfere with the enterohepatic circulation by inhibiting bowel flora and suppressing metabolism of the drug by bacteria " Thank you, Mark Quote Link to comment Share on other sites More sharing options...
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