Guest guest Posted April 20, 2001 Report Share Posted April 20, 2001 Each parent, each of theirs, each of theirs, etc. must be a carrier, the chances for each pregnancy between carriers being: 2 carriers, 1 cfer, 1 neither, but no guarantees--those are just statistical odds; the post you read was probably one of my horrors Sorry, here I go again, n Rojas Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 21, 2001 Report Share Posted April 21, 2001 Patty, Yes both parents MUST be a carrier for the child to have cf. Re:CFchild/r > Hi! I am extremely comp illiterate, cant figure out how to pull up post I > read to show all, but one said they thought if child had CF, as parents the > odds were " extremely high " that the parents are carriers. I thought you HAVE > to be a carrier(both mom and dad). Did I misunderstand? > Love from....Patty > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 21, 2001 Report Share Posted April 21, 2001 I believe Torsten was just leaving open the unlikely (but possible) possibility that someone has mutated on their own. In that case they wouldn't have to inherit a mutation - they made their own! This is very, very rare, but all of the mutations started somewhere. Lori Mom to Scout 2 wCF Re:CFchild/r Hi! I am extremely comp illiterate, cant figure out how to pull up post I read to show all, but one said they thought if child had CF, as parents the odds were " extremely high " that the parents are carriers. I thought you HAVE to be a carrier(both mom and dad). Did I misunderstand? Love from....Patty Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2001 Report Share Posted April 22, 2001 In a message dated 4/20/2001 10:11:56 PM Eastern Daylight Time, PLH3395@... writes: << if child had CF, as parents the odds were " extremely high " that the parents are carriers. I thought you HAVE to be a carrier(both mom and dad). Did I misunderstand? >> In order for a child to have CF BOTH Parents MUST AND ARE rs.... You were right. Rosemary in NY with 3 kids with CF ages 10, 8 and 4! e-mail : Rosemary3for3wCF@... Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2001 Report Share Posted April 22, 2001 Except in the very rare instance where someone mutates on his/her own. It is very, very rare, but possible - I believe that is what Torsten was talking about. The continued possibility of new mutations is why there are so many different mutations. I would guess that DeltaF508 is one of the oldest mutations and those of us with " unknown " mutations have much newer ones - which could still mean they originated thousands of years ago. Lori Mom to Scout 2 wCF Re: Re:CFchild/r In a message dated 4/20/2001 10:11:56 PM Eastern Daylight Time, PLH3395@... writes: << if child had CF, as parents the odds were " extremely high " that the parents are carriers. I thought you HAVE to be a carrier(both mom and dad). Did I misunderstand? >> In order for a child to have CF BOTH Parents MUST AND ARE rs.... You were right. Rosemary in NY with 3 kids with CF ages 10, 8 and 4! e-mail : Rosemary3for3wCF@... PLEASE do not post religious emails to the list. ------------------------------------------- The opinions and information exchanged on this list should IN NO WAY be construed as medical advice. PLEASE CONSULT YOUR PHYSICIAN BEFORE CHANGING ANY MEDICATIONS OR TREATMENTS. -------------------------------------------------- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2001 Report Share Posted April 22, 2001 you do>>>>>>>>>>>>>>>>! love, grdmbev Re: Re:CFchild/r In a message dated 4/20/2001 10:11:56 PM Eastern Daylight Time, PLH3395@... writes: << if child had CF, as parents the odds were " extremely high " that the parents are carriers. I thought you HAVE to be a carrier(both mom and dad). Did I misunderstand? >> In order for a child to have CF BOTH Parents MUST AND ARE rs.... You were right. Rosemary in NY with 3 kids with CF ages 10, 8 and 4! e-mail : Rosemary3for3wCF@... PLEASE do not post religious emails to the list. ------------------------------------------- The opinions and information exchanged on this list should IN NO WAY be construed as medical advice. PLEASE CONSULT YOUR PHYSICIAN BEFORE CHANGING ANY MEDICATIONS OR TREATMENTS. -------------------------------------------------- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2001 Report Share Posted April 22, 2001 I believe that there is a souce for three cf mothers allegedly having at least one child where the father was not identified as a carrier; even this seems unlikely to me and to the researchers I know; after all with 900 mutations of thereabouts, few are tested for all. n Rojas who still believes that it takes two carriers to produce a cf child, but one never knows what next! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2001 Report Share Posted April 22, 2001 Every single text and each of the doctors I have talked to,- has said that even tho we might not have the number, there has to be a father and mother, who each ARE carriers. This was a seminar at a conference..can't remember which one right now, when I do , I will try to look up the speakers.They were emphatic about that. I would like to see the text/research that says differently. It sure would make some people happy , not being responsible.....:):0 LOVE, GRNDMBEV Re: Re:CFchild/r I believe that there is a souce for three cf mothers allegedly having at least one child where the father was not identified as a carrier; even this seems unlikely to me and to the researchers I know; after all with 900 mutations of thereabouts, few are tested for all. n Rojas who still believes that it takes two carriers to produce a cf child, but one never knows what next! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2001 Report Share Posted April 22, 2001 What do you mean by someone mutating on their own? Re: Re:CFchild/r > > In a message dated 4/20/2001 10:11:56 PM Eastern Daylight Time, > PLH3395@... writes: > > << if child had CF, as parents the > odds were " extremely high " that the parents are carriers. I thought you > HAVE > to be a carrier(both mom and dad). Did I misunderstand? >> > In order for a child to have CF BOTH Parents MUST AND ARE rs.... You > were right. > > Rosemary in NY with 3 kids with CF > ages 10, 8 and 4! > e-mail : Rosemary3for3wCF@... > > > > PLEASE do not post religious emails to the list. > > > ------------------------------------------- > > > The opinions and information exchanged on this list should > IN NO WAY > be construed as medical advice. > > PLEASE CONSULT YOUR PHYSICIAN BEFORE CHANGING ANY MEDICATIONS OR TREATMENTS. > > -------------------------------------------------- > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 23, 2001 Report Share Posted April 23, 2001 Here are a couple of web sites. I had a hard time finding any that weren't too full of scientific mumbo jumbo. Anyway the first one is just an outline, but pretty straightforward. Basically, (forgive me if you already know all this or if I don't say it properly, I am far from a scientist) we are all probably carriers (as parents of children with CF) of a mutation in a gene everyone has - the CF gene. Depending on which mutation we carry the alteration is in a different place on it and may produce a different initial effect (stop versus folding problem for example), but the overall effect is what we call CF. Each of these mutations at some point happened to a previously unmutated gene and then was passed down through the generations. A mutation like DeltaF508 that is the most common has probably been around the longest and has had the most time to spread. Some of the less common mutations are either newer or for some reason weren't passed along as easily. Genetic mutations happen not just to the CF gene but other genes as well. Sometimes it causes no problems, sometimes it does. It isn't a process that has ever stopped happening however - humans continue to change and our genes continue to mutate. It is just that it doesn't happen very frequently - more like one is so many million times - but if you consider how many humans there are being born then you realize that still means a lot of new mutations can pop up. Some (not all) may be in the CF gene. So while it is much more likely that when a mutation comes back as unknown on the current list of known mutations that it is an old one that is just " unknown " it is always possible that it is a new mutation and that person tested was where it originated. All mutations started somewhere with one person. This beautiful mutation process also explains why there are over 900 known mutations not just the most common DeltaF508. I am sure there is someone else out there with a better grip on this than me - please jump in and correct me if I made a glaring error. Lori Mom to Scout 2 wCF " Gene Mutations 1. Gene mutations provide new alleles, and therefore are the ultimate source of variation. 2. A gene mutation is an alteration in the DNA (deoxyribonucleic acid) nucleotide sequence of an allele. 3. Mutations occur at random. 4. Mutations can be beneficial, neutral, or harmful. " Excerpt from - http://www.mhhe.com/biosci/genbio/maderbio6e/outlines/ch19out.mhtml " Population Genetics | Back to Top A population is a group of potentially interbreeding organisms of the same species occupying a certain area. Members of a population vary from one another. This variation is the raw material on which natural selection operates. There are several types of mutations, both at the gene-level and the chromosome-level. Gene mutations provide new alleles, making these mutations the ultimate source of variation. A gene mutation is an alteration in the DNA nucleotide sequence, producing an alternate sequence, termed an allele. Mutations occur at random, and can be beneficial, neutral, or harmful. Some chromosomal mutations are changes in the number of chromosomes inherited, while others are alterations in arrangement of alleles on chromosomes due to inversions and translocations. In sexually reproducing organisms, genetic recombination is the realloc ation of alleles and chromosomes. Recombination results from crossing-over during meiosis, the random segregation of chromosomes to gametes during meiotic division, and the random combination of gametes during fertilization. The entire genotype is subject to natural selection since new combinations of alleles may have improve the reproductive success of the organism. For polygenic traits, the most favorable combination may occur when the right alleles group by recombination. Not only are variations created, they are also preserved and passed on from one generation to the next.The gene pool is the total of all the alleles in a population, in the context of gene frequencies. Neither dominance nor sexual reproduction will change allele frequencies. " Above excerpt from - http://gened.emc.maricopa.edu/bio/bio181/BIOBK/BioBookEVOLII.html Re: Re:CFchild/r What do you mean by someone mutating on their own? Re: Re:CFchild/r > > In a message dated 4/20/2001 10:11:56 PM Eastern Daylight Time, > PLH3395@... writes: > > << if child had CF, as parents the > odds were " extremely high " that the parents are carriers. I thought you > HAVE > to be a carrier(both mom and dad). Did I misunderstand? >> > In order for a child to have CF BOTH Parents MUST AND ARE rs.... You > were right. > > Rosemary in NY with 3 kids with CF > ages 10, 8 and 4! > e-mail : Rosemary3for3wCF@... > > > > PLEASE do not post religious emails to the list. > > > ------------------------------------------- > > > The opinions and information exchanged on this list should > IN NO WAY > be construed as medical advice. > > PLEASE CONSULT YOUR PHYSICIAN BEFORE CHANGING ANY MEDICATIONS OR TREATMENTS. > > -------------------------------------------------- > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 24, 2001 Report Share Posted April 24, 2001 Hey n, are you sure they had the right father? He he , who unfortunately knows who Shantell's father was! Re: Re:CFchild/r I believe that there is a souce for three cf mothers allegedly having at least one child where the father was not identified as a carrier; even this seems unlikely to me and to the researchers I know; after all with 900 mutations of thereabouts, few are tested for all. n Rojas who still believes that it takes two carriers to produce a cf child, but one never knows what next! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 24, 2001 Report Share Posted April 24, 2001 << I believe that there is a souce for three cf mothers allegedly having at least one child where the father was not identified as a carrier; even this seems unlikely to me and to the researchers I know; after all with 900 mutations of thereabouts, few are tested for all. >> so, n, in these three cases....did they test for all 900 mutations, or just the standard genzyme test? Jen Quote Link to comment Share on other sites More sharing options...
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