Re: DR. CHIU - FWIW / Doseage - long term diease

[Guest guest]

that might be true, but I think it really gets down to the individual. I

started on 200mg daily from the beginning and never had a side effect and

wasn't taking anything other than Nsaids - docs say I have an aggressive

form of the disease (although have not accumulated the damage (yet) that you

have). The O'Dell study was treating people with early arthritis if I'm not

wrong and I don't think that very many had serious side effects that made

them go off the drug (I'm saying this from recollection as I am feeling lazy

at the moment and don't want to go dig up the study. . I know that some

here have a lot of difficulty with that dosage. I wonder if there are any

significant differences between men and women ? There aren't many men here,

but I know I don't herx easily - wonder if it effects women more than men?

Don't want to get anyone riled up here, just wondering.

Mark

rheumatic DR. CHIU - FWIW / Doseage - long term diease

> Dr. Chiu,

>

> You may recall I've had dx'd RA for some 13+ yrs, and leading but

> intermittent symptoms at least 15 yrs prior to that, and have serious

> bone erosion in one arm. When I started on the AP I went straight onto

> 100mg/2x/d Mino at first, but had dizziness with that, then to

> Doxycycline with which I have had no problems. I had used the RA Spes

> exclusively for 8 months prior to put the disease into remission (again)

> but realized remission=sleep, not cure. In agreement with that

> simplistic description my MD agreed to start antibiotics at the O'Dell

> rate. My thinking is that the RAS enabled me to start right out on the

> high doses and stay there, severely limiting any Herx's. That may be

> wrong but the point that I hope may be of some help is that some, even

> with long-standing very serious, extremely aggressive and destructive

> disease as mine is described tome by my Rheumy with a bazillion

> impressive letters after his name, fellowships, etc., can go right onto

> the 200mg/d. HTH with some of your people.

>

> Regards,

>

> Geoff Crenshaw, ACC -----------------------

> Captain Cook's Cruise Center ** Usual Disclaimers **

> -----------------------

> Religion: Man's attempt to discover God

> Christianity: God's offer to save humankind

>

>

>

>

[Guest guest]

In article <004901bf27a9$87966540$5746d8cc@cccc>, Geoff Crenshaw

<geoff@...> writes

>wrong but the point that I hope may be of some help is that some, even

>with long-standing very serious, extremely aggressive and destructive

>disease as mine is described tome by my Rheumy with a bazillion

>impressive letters after his name, fellowships, etc., can go right onto

>the 200mg/d. HTH with some of your people.

Well, there is no doubt that this is true - otherwise the dropout rate

from some of the earlier Minocycline trials which were done in

established disease would have been huge.

However, I still think it is prudent to build up the dose.

-------

Regards, Dr Graham Chiu

[Guest guest]

In article <004901bf27a9$87966540$5746d8cc@cccc>, Geoff Crenshaw

<geoff@...> writes

>wrong but the point that I hope may be of some help is that some, even

>with long-standing very serious, extremely aggressive and destructive

>disease as mine is described tome by my Rheumy with a bazillion

>impressive letters after his name, fellowships, etc., can go right onto

>the 200mg/d. HTH with some of your people.

Well, there is no doubt that this is true - otherwise the dropout rate

from some of the earlier Minocycline trials which were done in

established disease would have been huge.

However, I still think it is prudent to build up the dose.

-------

Regards, Dr Graham Chiu

[Guest guest]

Do you generally recommend that people try to increase to 200 mg daily if

they are doing well on 200 mg MWF? Would this make it possible to use just

Minocin rather than adding Clindamycin or Zithromax?

>>impressive letters after his name, fellowships, etc., can go right onto

>>the 200mg/d. HTH with some of your people.

>

>Well, there is no doubt that this is true - otherwise the dropout rate

>from some of the earlier Minocycline trials which were done in

>established disease would have been huge.

>

>However, I still think it is prudent to build up the dose.

>

>-------

>Regards, Dr Graham Chiu

>

>>

[Guest guest]

In article <00c701bf27fa$f98f7960$198dfad1@ken-greason>, Ken and

<kglg@...> writes

>Do you generally recommend that people try to increase to 200 mg daily if

>they are doing well on 200 mg MWF? Would this make it possible to use just

>Minocin rather than adding Clindamycin or Zithromax?

Peoples assessments of doing well don't often coincide with my own

assessments. For instance, the patient may say that they have no pain

or stiffness, and no disability. Yet on examination I find ongoing

synovitis.

I think if the bloods and examination are fine, then keep the same dose.

Otherwise aim for the maximal dose.

-------

Regards, Dr Graham Chiu