Arthritis cure 'promising'

November 19, 1999

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Friday, November 19, 1999

Arthritis cure 'promising'

By SHARON LEM, TORONTO SUN

Toronto scientists who may have found a potential cure for arthritis and

other inflammatory diseases say their theory " shows big promise " to shut down

the crippling effect of arthritis.

Researchers at Princess Margaret Hospital/Ontario Cancer Institute and

AMGEN Research Institute were still celebrating yesterday after racing to become

the first in the world to identify the molecular key to preventing joint, bone

and cartilage deterioration in rats.

Phase-one trials for toxicity tests in humans were done earlier this year.

Phase-two trials, which will compare the drug treatment on arthritics to

traditional treatment, begins in early 2000.

" We believe it's a potential cure for arthritis and other inflammatory

diseases, but only clinical trials on humans will test how effective it is, "

said lead author Dr. f Penninger, an immunologist at PMH/OCI and AMGEN.

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