Re: Minocycline, doxycycline & Biaxin

[Guest guest]

> " Minocycline has been shown to have antiinflammatory, immunomodulatory,

and

> chondroprotective effects in addition to its antibacterial activity.

> Tetracyclines, particularly minocycline and doxycycline, are potent

inhibitors

> of metalloproteinases, including collagenase and gelatinase. "

I don't see where this says minocycline has these properties to the

exclusion of other tetracyclines. If you'll note in the following

conclusions in the abstract I posted yesterday, doxy does exhibit

anti-inflammatory properties in this study.

~~~~~~~quoting~~~~~

Doxycycline inhibition of interleukin-1 in the corneal epithelium.

Invest Ophthalmol Vis Sci 2000 Aug;41(9):2544-57 (ISSN: 0146-0404)

A; Rosenblatt M; Li DQ; Liu Z; Monroy D; Ji Z; Lokeshwar BL;

Pflugfelder SC [Find other articles with these Authors]

Ocular Surface and Tear Center, Bascom Palmer Eye Institute, Department of

Ophthalmology, University of Miami School of Medicine, Florida 33136, USA.

CONCLUSIONS:

Doxycycline can suppress the steady state amounts of mRNA and protein of

IL-beta and decrease the bioactivity of this major inflammatory cytokine.

These data may partially explain the clinically observed anti-inflammatory

properties of doxycycline. The observation that doxycycline was equally

potent as a corticosteroid, combined with the relative absence of adverse

effects, makes it a potent drug for a wide spectrum of ocular surface

inflammatory diseases.

~~~~~~~~~~~

It has been noted here previously in group discussions that minocin has

better tissue penetration, so perhaps this is a pertinent factor in relative

inflammation relief. I would venture an unscientific guess that some of the

anti-inflammatory action is related to the anti-microbial action, i.e. by

reducing certain microbes, the triggering of inflammation is reduced. This

may account for the varying mileage different patients experience with

different antibiotics. Tetracycline Hcl did reduce my inflammation in the

long run, in all but a few joints.

Thanks, as always, for your thoughtful and insightful posts! Liz G

PS What Martha was describing sounds more like water-retention edema than

inflammation, in my opinion.

[Guest guest]

I didn't see where it said that either, frankly.

Anyway, having switched from Minocin to doxy about a month and a half now

(due to hyperpigmentation), I have noticed absolutely no increased swelling

(thank God). I have noticed more achiness in my fingers and other areas from

time to time but not sure if it's because I've been cheating on snacking

before and after or if it's actually cuz of the switch. I had only about a

week or so of definite pain increase due to switch but certainly nothing

unbearable. But, again, no swelling at all. So for those considering

switching for whatever reason, I can say that based on my own experience,

swelling is not an issue.

Babs

RA 8/98, DX 4/99, AP 11/99

200 mg. doxycycline

112 mcg. Synthroid

2 mg. Hytrin

Mestinon

Vits. & Misc. Suplmts.

[Guest guest]

Hi Everyone, I also switched from tetracycline to doxycyline about 3 months

ago for a maintance and I feel good on it and have no swelling and it seems

to be doing the job so far, I seem to feel better. from Ohio, Oh yea

everyone have a good day

[Guest guest]

I know everyone is an individual

with medications - but I was asking

had anyone experience swelling with

doxy - I am convinced mine is not

from doxy - so I am sorry if I gave

the impression is WAS from doxy - just

asking - thanks everyone for your input.

You guys are great!

I will be able to get minocycline and start

back next week - by the way the orthopedic

physician in St. Augustine, Fla (previously lived)

recommends doxy - everytime rather than minocin -

so it differs a little - same result!! GO FOR IT

everyone AP -

Martha

>From: Babs56p@...

>pioneer@..., rheumaticegroups

>Subject: Re: rheumatic Minocycline, doxycycline & Biaxin

>Date: Sat, 28 Oct 2000 09:43:54 EDT

>

>I didn't see where it said that either, frankly.

>

>Anyway, having switched from Minocin to doxy about a month and a half now

>(due to hyperpigmentation), I have noticed absolutely no increased swelling

>(thank God). I have noticed more achiness in my fingers and other areas

>from

>time to time but not sure if it's because I've been cheating on snacking

>before and after or if it's actually cuz of the switch. I had only about a

>week or so of definite pain increase due to switch but certainly nothing

>unbearable. But, again, no swelling at all. So for those considering

>switching for whatever reason, I can say that based on my own experience,

>swelling is not an issue.

>

>Babs

>RA 8/98, DX 4/99, AP 11/99

>200 mg. doxycycline

>112 mcg. Synthroid

>2 mg. Hytrin

>Mestinon

>Vits. & Misc. Suplmts.

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