Journal Article On Curcumin

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Department of Horticulture and National Food Safety and Toxicology Center,

Michigan State University, East Lansing 48824, USA.

<<Curcumin I, curcumin II (monodemethoxycurcumin) and curcumin III

(bisdemethoxycurcumin) from Curcuma longa were assayed for their cytotoxicity,

antioxidant and anti-inflammatory activities. These compounds showed activity

against leukemia, colon, CNS, melanoma, renal, and breast cancer cell lines.

The inhibition of liposome peroxidation by curcumins I-III at 100 microg/ml

were 58, 40 and 22%, respectively. The inhibition of COX-I and COX-II enzymes

by the curcumins was observed. Curcumins I-III were active against COX-I

enzyme at 125 microg/ml and showed 32, 38.5 and 39.2% inhibition of the

enzyme, respectively. Curcumins I-III also showed good inhibition of the

COX-II enzyme at 125 mg/ml with 89.7, 82.5 and 58.9% inhibition of the enzyme,

respectively.>>

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Journal of Phyomedicine, 2000, Jul;7(4),303-8

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REGARDS,

ray

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