RE: Re:: Big study identifies new genes that may be involved in autism

[Guest guest]

Diane,

I always thought they were the same. What fascinates me about psychological

labels is that it displays a percentage. If a person has a certain

psychological condition there is a higher chance a sibling will also develop the

problem than the general public. And the percentage goes even higher for identical

twins. But how do you explain those people in those groups who do not develop

the problem.

I

don't think genetics can explain how fast the numbers have grown. If we really

didn't fully understand the problem before and we placed all those people into

institutions that means there should be a large decrease in institutionalized

adults. And speaking of adults, where are they?

From:

sList [mailto:sList ] On Behalf

Of Diane Rosenstein

Sent: Sunday, June 13, 2010 1:22 AM

To: sList

Subject: Re:: Big study identifies new genes that may be

involved in autism

What

I found most interesting in the blurb about the study was that there were some

children who had gene (alterations or deletions) that their parents DID NOT

have.

I've

always assumed that " genetic " was the same as

" inherited " . Obviously, this is not true.

(I

also wondered how they fit just under 7 generations into just 30 years with

100% inheritance rate too whenever I heard " autism is genetic " ;

that is 1 in 10,000 to 1 in 91 in just 30 years!)

Did

anyone else think that " autism is genetic " meant " passed down

from the parent " also?

[Guest guest]

has it not been already a known that genetic mutations can occur after

birth? or are we still thinking that genetic mutations can only happen

prebirth and through inherited circumstances? it's been discovered that

genetic mutations can and have occured after birth through other forms

that are not necassarily inherited, look at the Gulf War Syndrome vets,

who have succumbed to numerous genetic mutations.

there are adults, probably tossed away under some other label. i am

one adult. and i do have a genetic mutation, i'm 41 but have adapted

and assimilated well although i was largely non verbal until age 5-6.

and had limited speech for years, functional speech occured very late,

i was echolic for years. i'm not so sensory senstive as i was when

younger and move much better in the world now, it did take awhile to

catch up on things but i did do so eventually, apparently i still get

anxious enough to get baker acted, which i'm still sore about. i was

not daignosed as being on the spectrum when i was younger because at

that time it wasn't recognized well enough to be diagnosed with it. i

was diagnosed as mentally retarded until age 12. until that didn't fit,

and i was in MR, LD and emotionally disturbed clasrooms growing up.

diagnosis was LD, MR, mental illness in a child, OCD, anxiety disorder,

speech impaired. the term 'autistic characteristics' was never even

brought up in regards to me until i was in my early teens and back then

no one really knew what that meant anyhow, the term was brought up

again only after my child and neices and nephews came about and i was

cornered by their neurologist who requested my full medical history

after meeting me. many adults that would have fit into the autistic

spectrum today were never diagnosed as such when they were a child.

there are adults. and there are numerous undiagnosed adults. i was fist

penned the 'autistic characteristics' term idly at age 12. not that it

meant anything back then.

my child is much greater affected and her prognosis isn't good, she

also has Rett Syndrome, which is the severest form of the autistic

spectrum, it came with a physical regession as well as social one, and

all of my sisters and brothers kids are on the spectrum as well. her

youngest was not vaccinated but she is still on the spectrum but she is

the higher functioning one and the one with least medical issues. she

is more 'different' than 'disabled' more in the just quirky and

eccentric arena. my brothers son and borther's daughter are higher

functioning and are still diagnosed as being on the spectrum but they

are no different if not higher functioning than i was when i was a

child. had they been born back when i was they would not have been

diagnosed as being on the autistic spectrum as they are now. so there

is a mix of issues at play. greater awareness, genetics, and of course

the environmental triggers involved that i feel play a big part of what

is autism today.

Juli

Re:: Big study identifies new genes that may

beinvolved in autism

  WhatI found most interesting in the blurb about the study was that

there were somechildren who had gene (alterations or deletions) that

their parents DID NOThave.

Â

I'vealways assumed that " genetic " was the same as " inherited " .Â

Obviously, this is not true.

Â

 (Ialso wondered how they fit just under 7 generations into just 30

years with100% inheritance rate too whenever I heard " autism is

genetic " ;Â that is 1 in 10,000 to 1 in 91 in just 30 years!)

Â

Didanyone else think that " autism is genetic " meant " passed downfrom

the parent " also?

Â

Â

[Guest guest]

Juli and other readers,

Retts is not part of ASD and must not be confused with ASD. Retts and autism are both Pervasive Developmental Disorders, that's all what they have in common. Retts is very different from ASD, and typically visible due to the baby's large head and severe psychomotor difficulties at a very young age.

Mutations that we can get as a result of poison in the air or simply the UV from the sun cannot be passed on to our children. Men who returned from the Gulf War, for example, should not get children with autism because of their exposure to chemicals. This is important to know.

There is actually research that shows that Army men tend to father more kids with ADHD, but less than the average with autism. Other research shows that men with ADHD tend to be attracted to careers like the Army (that's where the action is, no dull moment there..) In other words, men who came back from Iraq had ADHD before they went there. They did not get it while they were there.

How do you know that you have a genetic mutation as opposed to a inherited or passes on gene?

Liz

To: sList Sent: Mon, June 14, 2010 10:53:37 AMSubject: RE: Re:: Big study identifies new genes that may be involved in autism

has it not been already a known that genetic mutations can occur after birth? or are we still thinking that genetic mutations can only happen prebirth and through inherited circumstances? it's been discovered that genetic mutations can and have occured after birth through other forms that are not necassarily inherited, look at the Gulf War Syndrome vets, who have succumbed to numerous genetic mutations.there are adults, probably tossed away under some other label. i am one adult. and i do have a genetic mutation, i'm 41 but have adapted and assimilated well although i was largely non verbal until age 5-6. and had limited speech for years, functional speech occured very late, i was echolic for years. i'm not so sensory senstive as i was when younger and move much better in the world now, it did take awhile to catch up on things but i did do so eventually, apparently i still get anxious enough to

get baker acted, which i'm still sore about. i was not daignosed as being on the spectrum when i was younger because at that time it wasn't recognized well enough to be diagnosed with it. i was diagnosed as mentally retarded until age 12. until that didn't fit, and i was in MR, LD and emotionally disturbed clasrooms growing up. diagnosis was LD, MR, mental illness in a child, OCD, anxiety disorder, speech impaired. the term 'autistic characteristics' was never even brought up in regards to me until i was in my early teens and back then no one really knew what that meant anyhow, the term was brought up again only after my child and neices and nephews came about and i was cornered by their neurologist who requested my full medical history after meeting me. many adults that would have fit into the autistic spectrum today were never diagnosed as such when they were a child. there are adults. and there are

numerous undiagnosed adults. i was fist penned the 'autistic characteristics' term idly at age 12. not that it meant anything back then.my child is much greater affected and her prognosis isn't good, she also has Rett Syndrome, which is the severest form of the autistic spectrum, it came with a physical regession as well as social one, and all of my sisters and brothers kids are on the spectrum as well. her youngest was not vaccinated but she is still on the spectrum but she is the higher functioning one and the one with least medical issues. she is more 'different' than 'disabled' more in the just quirky and eccentric arena. my brothers son and borther's daughter are higher functioning and are still diagnosed as being on the spectrum but they are no different if not higher functioning than i was when i was a child. had they been born back when i was they would not have been diagnosed as being

on the autistic spectrum as they are now. so there is a mix of issues at play. greater awareness, genetics, and of course the environmental triggers involved that i feel play a big part of what is autism today.Juli RE: Re:: Big study identifies new genes that may be involved in autism Diane,I always thought they were the same. What fascinates me about psychologicallabels is that it displays a percentage. If a person has a certainpsychological condition there is a higher chance a sibling will also

develop theproblem than the general public. And the percentage goes even higher for identicaltwins. But how do you explain those people in those groups who do not developthe problem. Idon't think genetics can explain how fast the numbers have grown. If we reallydidn't fully understand the problem before and we placed all those people intoinstitutions that means there should be a large decrease in institutionalizedadults. And speaking of adults, where are they? From:sList [mailto:sList ] On BehalfOf Diane RosensteinSent: Sunday, June 13, 2010 1:22 AMTo: sList Subject: Re:: Big study identifies new genes that may beinvolved in autism WhatI found most interesting in the blurb about the study was that there were somechildren who had gene (alterations or deletions) that their parents DID NOThave. I'vealways assumed that "genetic" was the same as"inherited". Obviously, this is not true. (Ialso wondered how they fit just under 7 generations into just 30 years with100% inheritance rate too whenever I heard "autism is genetic"; that is 1 in 10,000 to 1 in 91 in just 30 years!) Didanyone else think that "autism is genetic" meant "passed downfrom the parent" also?

[Guest guest]

Juli and other readers,

Retts is not part of ASD and must not be confused with ASD. Retts and autism are both Pervasive Developmental Disorders, that's all what they have in common. Retts is very different from ASD, and typically visible due to the baby's large head and severe psychomotor difficulties at a very young age.

Mutations that we can get as a result of poison in the air or simply the UV from the sun cannot be passed on to our children. Men who returned from the Gulf War, for example, should not get children with autism because of their exposure to chemicals. This is important to know.

There is actually research that shows that Army men tend to father more kids with ADHD, but less than the average with autism. Other research shows that men with ADHD tend to be attracted to careers like the Army (that's where the action is, no dull moment there..) In other words, men who came back from Iraq had ADHD before they went there. They did not get it while they were there.

How do you know that you have a genetic mutation as opposed to a inherited or passes on gene?

Liz

To: sList Sent: Mon, June 14, 2010 10:53:37 AMSubject: RE: Re:: Big study identifies new genes that may be involved in autism

has it not been already a known that genetic mutations can occur after birth? or are we still thinking that genetic mutations can only happen prebirth and through inherited circumstances? it's been discovered that genetic mutations can and have occured after birth through other forms that are not necassarily inherited, look at the Gulf War Syndrome vets, who have succumbed to numerous genetic mutations.there are adults, probably tossed away under some other label. i am one adult. and i do have a genetic mutation, i'm 41 but have adapted and assimilated well although i was largely non verbal until age 5-6. and had limited speech for years, functional speech occured very late, i was echolic for years. i'm not so sensory senstive as i was when younger and move much better in the world now, it did take awhile to catch up on things but i did do so eventually, apparently i still get anxious enough to

get baker acted, which i'm still sore about. i was not daignosed as being on the spectrum when i was younger because at that time it wasn't recognized well enough to be diagnosed with it. i was diagnosed as mentally retarded until age 12. until that didn't fit, and i was in MR, LD and emotionally disturbed clasrooms growing up. diagnosis was LD, MR, mental illness in a child, OCD, anxiety disorder, speech impaired. the term 'autistic characteristics' was never even brought up in regards to me until i was in my early teens and back then no one really knew what that meant anyhow, the term was brought up again only after my child and neices and nephews came about and i was cornered by their neurologist who requested my full medical history after meeting me. many adults that would have fit into the autistic spectrum today were never diagnosed as such when they were a child. there are adults. and there are

numerous undiagnosed adults. i was fist penned the 'autistic characteristics' term idly at age 12. not that it meant anything back then.my child is much greater affected and her prognosis isn't good, she also has Rett Syndrome, which is the severest form of the autistic spectrum, it came with a physical regession as well as social one, and all of my sisters and brothers kids are on the spectrum as well. her youngest was not vaccinated but she is still on the spectrum but she is the higher functioning one and the one with least medical issues. she is more 'different' than 'disabled' more in the just quirky and eccentric arena. my brothers son and borther's daughter are higher functioning and are still diagnosed as being on the spectrum but they are no different if not higher functioning than i was when i was a child. had they been born back when i was they would not have been diagnosed as being

on the autistic spectrum as they are now. so there is a mix of issues at play. greater awareness, genetics, and of course the environmental triggers involved that i feel play a big part of what is autism today.Juli RE: Re:: Big study identifies new genes that may be involved in autism Diane,I always thought they were the same. What fascinates me about psychologicallabels is that it displays a percentage. If a person has a certainpsychological condition there is a higher chance a sibling will also

develop theproblem than the general public. And the percentage goes even higher for identicaltwins. But how do you explain those people in those groups who do not developthe problem. Idon't think genetics can explain how fast the numbers have grown. If we reallydidn't fully understand the problem before and we placed all those people intoinstitutions that means there should be a large decrease in institutionalizedadults. And speaking of adults, where are they? From:sList [mailto:sList ] On BehalfOf Diane RosensteinSent: Sunday, June 13, 2010 1:22 AMTo: sList Subject: Re:: Big study identifies new genes that may beinvolved in autism WhatI found most interesting in the blurb about the study was that there were somechildren who had gene (alterations or deletions) that their parents DID NOThave. I'vealways assumed that "genetic" was the same as"inherited". Obviously, this is not true. (Ialso wondered how they fit just under 7 generations into just 30 years with100% inheritance rate too whenever I heard "autism is genetic"; that is 1 in 10,000 to 1 in 91 in just 30 years!) Didanyone else think that "autism is genetic" meant "passed downfrom the parent" also?

[Guest guest]

Juli and other readers,

Retts is not part of ASD and must not be confused with ASD. Retts and autism are both Pervasive Developmental Disorders, that's all what they have in common. Retts is very different from ASD, and typically visible due to the baby's large head and severe psychomotor difficulties at a very young age.

Mutations that we can get as a result of poison in the air or simply the UV from the sun cannot be passed on to our children. Men who returned from the Gulf War, for example, should not get children with autism because of their exposure to chemicals. This is important to know.

There is actually research that shows that Army men tend to father more kids with ADHD, but less than the average with autism. Other research shows that men with ADHD tend to be attracted to careers like the Army (that's where the action is, no dull moment there..) In other words, men who came back from Iraq had ADHD before they went there. They did not get it while they were there.

How do you know that you have a genetic mutation as opposed to a inherited or passes on gene?

Liz

To: sList Sent: Mon, June 14, 2010 10:53:37 AMSubject: RE: Re:: Big study identifies new genes that may be involved in autism

has it not been already a known that genetic mutations can occur after birth? or are we still thinking that genetic mutations can only happen prebirth and through inherited circumstances? it's been discovered that genetic mutations can and have occured after birth through other forms that are not necassarily inherited, look at the Gulf War Syndrome vets, who have succumbed to numerous genetic mutations.there are adults, probably tossed away under some other label. i am one adult. and i do have a genetic mutation, i'm 41 but have adapted and assimilated well although i was largely non verbal until age 5-6. and had limited speech for years, functional speech occured very late, i was echolic for years. i'm not so sensory senstive as i was when younger and move much better in the world now, it did take awhile to catch up on things but i did do so eventually, apparently i still get anxious enough to

get baker acted, which i'm still sore about. i was not daignosed as being on the spectrum when i was younger because at that time it wasn't recognized well enough to be diagnosed with it. i was diagnosed as mentally retarded until age 12. until that didn't fit, and i was in MR, LD and emotionally disturbed clasrooms growing up. diagnosis was LD, MR, mental illness in a child, OCD, anxiety disorder, speech impaired. the term 'autistic characteristics' was never even brought up in regards to me until i was in my early teens and back then no one really knew what that meant anyhow, the term was brought up again only after my child and neices and nephews came about and i was cornered by their neurologist who requested my full medical history after meeting me. many adults that would have fit into the autistic spectrum today were never diagnosed as such when they were a child. there are adults. and there are

numerous undiagnosed adults. i was fist penned the 'autistic characteristics' term idly at age 12. not that it meant anything back then.my child is much greater affected and her prognosis isn't good, she also has Rett Syndrome, which is the severest form of the autistic spectrum, it came with a physical regession as well as social one, and all of my sisters and brothers kids are on the spectrum as well. her youngest was not vaccinated but she is still on the spectrum but she is the higher functioning one and the one with least medical issues. she is more 'different' than 'disabled' more in the just quirky and eccentric arena. my brothers son and borther's daughter are higher functioning and are still diagnosed as being on the spectrum but they are no different if not higher functioning than i was when i was a child. had they been born back when i was they would not have been diagnosed as being

on the autistic spectrum as they are now. so there is a mix of issues at play. greater awareness, genetics, and of course the environmental triggers involved that i feel play a big part of what is autism today.Juli RE: Re:: Big study identifies new genes that may be involved in autism Diane,I always thought they were the same. What fascinates me about psychologicallabels is that it displays a percentage. If a person has a certainpsychological condition there is a higher chance a sibling will also

develop theproblem than the general public. And the percentage goes even higher for identicaltwins. But how do you explain those people in those groups who do not developthe problem. Idon't think genetics can explain how fast the numbers have grown. If we reallydidn't fully understand the problem before and we placed all those people intoinstitutions that means there should be a large decrease in institutionalizedadults. And speaking of adults, where are they? From:sList [mailto:sList ] On BehalfOf Diane RosensteinSent: Sunday, June 13, 2010 1:22 AMTo: sList Subject: Re:: Big study identifies new genes that may beinvolved in autism WhatI found most interesting in the blurb about the study was that there were somechildren who had gene (alterations or deletions) that their parents DID NOThave. I'vealways assumed that "genetic" was the same as"inherited". Obviously, this is not true. (Ialso wondered how they fit just under 7 generations into just 30 years with100% inheritance rate too whenever I heard "autism is genetic"; that is 1 in 10,000 to 1 in 91 in just 30 years!) Didanyone else think that "autism is genetic" meant "passed downfrom the parent" also?

[Guest guest]

hello, i am aware that many in the military have ADHD i was unaware

that their numbers of autistics weren't as much as the rest of the

population.

my mom had five brothers and they were drafted into the military years

ago, and our family seemed all okay until then. none of them are ADHD

although they had some kids with ADHD after. my mom wasn't in the

military but married my dad who was. that first crop of 'problem kids'

showed up in the sixties and thats when they heard the term ADHD for

the first time with some of my cousins, when i came around i showed up

with a whole different set of problems that they didn't know what to

make of.

my mom along with another uncle all had kids with ADHD, my mom also had

me; retarded and the same uncle with another amongst the ADHD kids he

had was also termed retarded. that was alarming back then, kids that

couldn't keep still, or shut up, or behave in school and two that

couldn't come out of their worlds. Resource rooms, and remedial

classes, special ed schools seemed to affect every one of my mom and

her brothers with this new crop of kids pepered in with their 'normals'

that they didn't understand what was happening or why. the " cousins

normal " as we called them, did okay and it was more the ones not

labeled ADHD that didn't go into the military as much. my mom being the

first one who had sons that did not join because they were ADHD, and my

one uncle who had one ADHD son who was tossed out after just a year

in, another uncle that didn't push for his ADHD son to go in, but that

cousin joined anyway not wanting to be left out by his 'normal'

brothers, and another uncle who felt that the military will be good for

his one ADHD son and encouraged his enlistment only later, both these

cousins were later to suffer Gulf War Syndrome, the one tossed out was

still very ADHD with a dishonorable discharge for the experience but

did get out Gulf Syndrome free. the 'cousins normals' came back okay.

the Gulf War cousins, (from different uncles) both had children that

died before the age of one, as well as having their wives suffer

miscarriages. when they both finally had a child born seemingly okay

the blessings soon turned to despair as in less than two years old both

boys ended up severely autistic. seemed like the next wave was worse

than the first as this time it was autism instead of out of control

ADHD kids. my family thought maybe being in the military had something

to do with things but that theory fell flat when my mom who had no

children join the military ended up with all her grandchildren being on

the spectrum, and my uncle's ADHD children who did not join the

military still ended up having autistic kids. then we thought about the

ADHD and maybe autism connection because it seemed that they suffered

the most. it was after all the two ADHD cousins who DID join that ended

up with Gulf War Syndrome and who had in turn suffered many autoimmune

issues. But the ADHD cousins and us, who did not join the military also

were beset with autistic kids.

so they thought that the first crop of problem ADHD generation seemed

to give birth to the next crop of even worse off autism generation.

only this fell flat too when two 'normal' cousins who were not

afflicted with ADHD and who had had some normal kids, all of a sudden

they themselves were affected with children that showed clear signs of

autism.

For awhile there it seemed safe to conclude that those of us who were

afflicted with ADHD will likely end up with autistic kids, since that

seemed to be the case, but that those of us that were 'normals' could

have kids that would likely be okay. with these two new cases any

solace in that thinking we had ended.

strangely we did have some of us that with some modifications like my

sister and one out of control ADHD cousin who were both affected with

autistic kids did change things like no vaccinating and no antibiotics

and live this grow your own food sort of lifestyle which is just too

much for me to follow or get into but they are growing their own food

in South Carolina and living preservative and additive free and somehow

ended up with three more kids that came out with far more positive

results.

We thought they were crazy because why would one severely affected ADHD

cousin with his two autistic kids, and my sister with severe ADHD

herself with three of hers on the autistic spectrum, ended up grouping

together, taking their spouses and convince them to actually bring more

children into the world? even if it was with hardcore inconvenient

practices, but their outcome did seem much better than the rest, even

very normal seeming, and beleive me we look them over for any signs

that may be amiss. now these new kids did also test positive for some

mutations as well but were not affected with symptoms or issues as the

rest of the kids, they were even normal seeming mostly, except for my

youngest neices quirkines and literal language issues, they came out

pretty normal and healthier. mind you that we are beset with other

medical conditions, a lot of autoimmune issues and other medical

problems like asthma, gastro issues, seizures, and blood problems, and

the sort. but we react strongly to many things, like my brother is

allergic to everything and most meds, me too, a flu shot almost killed

me at age 15, when i suffered Guillain Barre Syndrome, another shot

almost killed a cousin who ended up with Immune Thrombocytopenia

Purpora where her body was killing it's own blood platelets, this

condition also affected our Gulf War cousins, who also suffered immune

rheumatoid arthritis and their own bodies seemed to insist on attacking

itself, both of these cousins are in wheelchairs now and are disabled

and have severely affected autistic kids to boot, which is tragic.

it does seem that my crazy overactive cousin with ADHD and my just as

affected sis, who although had five kids on the spectrum seemed not to

have this deter them any, and they are living okay although i can't eat

all that tasteless squirrel food, or have patience in growing or

killing my own dinner. i mean they seem nuts, maybe i'm too addicted to

Macdonald's and cable and well everything that is convenient, but i

have to admit that their last three kids they are raising in their farm

are not affected or sick as the rest of us and their spectrum kids do

seem healthier even if they are just as autistic as they were before.

life does seem easier when there are less seizures, chronic medical

problems and gastro issues to deal with even if those five are still

just as autistic as before. so i do feel in OUR case a lot has to do

with genetic problems, but just as much so with environmental triggers.

My daughter reacted strongly from her vaccines and we saw a reaction

right away, she was actually in the hospital five hours later and was

admitted with back to back seizures for two weeks, but after they

stated later that it was Rett syndrome it seemed it didn't matter to

anyone how rapid or extreme her reaction was. we later discovered that

there were Rett cases that occured from vaccine reactions. but we were

told it was genetic. but if we have a genetic weakness wouldn't things

trigger us on many issues that wouldn't be triggered if some caution

was taken beforehand? i've thought this since i realized that there are

people with the Rett mutated gene who have the mildest symptoms or even

no symptoms at all.

mostly with us any who are planning kids many are considering a

strident lifestyle to prevent reactions from the environment in

triggering a genetic response that we feel can and will be triggered or

if that is too difficult some have decided on not having any children

at all. One cousin of my cousin insited in having her children through

IVF with donated eggs to prevent such genetic weakness from occuring in

her brood and even then she plans a modifed lifestyle.

we have no answers but many unaswered questions. and even as we are

picked and probbed we live life the best we can with hopes that one day

somewhow some answers may come, and even then knowing that it may not

make us feel any better or change anything maybe, but we just try the

best we can.

Juli

Re:: Big study identifies new genes that may

beinvolved in autism

  WhatI found most interesting in the blurb about the study was that

there were somechildren who had gene (alterations or deletions) that

their parents DID NOThave.

Â

I'vealways assumed that " genetic " was the same as " inherited " .Â

Obviously, this is not true.

Â

 (Ialso wondered how they fit just under 7 generations into just 30

years with100% inheritance rate too whenever I heard " autism is

genetic " ;Â that is 1 in 10,000 to 1 in 91 in just 30 years!)

Â

Didanyone else think t hat " autism is genetic " meant " passed downfrom

the parent " also?

Â

Â