Guest guest Posted April 22, 2002 Report Share Posted April 22, 2002 > Hi, > > I'm switching to PTU from 5mg Carbimazole daily, and have gone > slightly hyper and feel dreadful. > > Really keen to know if anyone else has switched to or from PTU, > and if so what drug and what dose they were on before and after > the switch, and why they switched. > > I can't find anything on dose equivalence between PTU and > Carbimazole. > > The doctor did some research but he clearly underestimated, I > suspect it is the short life of the PTU that is the problem. > > Anyway anyone who switched successfully (or otherwise?) please > tell me how the doses worked out. > > I've taken an extra half tab this evening, but I've been > sweating buckets on and off all day and could really do with a > sanity check on the dosing. > > Simon Hi Simon, welcome to the group :-) What dosage of PTU are you on? C Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2002 Report Share Posted April 22, 2002 Crawford wrote: > > > I'm switching to PTU from 5mg Carbimazole daily, and have gone > > slightly hyper and feel dreadful. > > welcome to the group :-) I've been dealing with this Graves thing a while (Started 1985, diagnosed 1991 grr, subtotal thyroidectomy 1995, hyper again 2000). Just never needed to know about PTU before, last time Carbimazole worked fine. > What dosage of PTU are you on? 50mg once daily. This is day three since switching from 5 mg Carbimazole daily. Yesterday I was hot and sweaty in the afternoon. I'm sitting here with a towel around me to mop up the sweat today, and a nasty headache lurking. The switch was because of alcohol intolerance whilst taking Carbimazole, and a strange ache in my left side just below the ribs which came and went. Right now I'm thinking not being able to sleep on your left side is a small price to pay for NOT being hyper The ache has gone - but then it came and went... Took an extra half tab (25mg) when I crawled out of bed for dinner this evening. Told doctor I'd try splitting dose into 25mg twice a day if I felt bad today. He trusts me not to do anything too radical with the dosing without checking with him. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2002 Report Share Posted April 22, 2002 Crawford wrote: > > > I'm switching to PTU from 5mg Carbimazole daily, and have gone > > slightly hyper and feel dreadful. > > welcome to the group :-) I've been dealing with this Graves thing a while (Started 1985, diagnosed 1991 grr, subtotal thyroidectomy 1995, hyper again 2000). Just never needed to know about PTU before, last time Carbimazole worked fine. > What dosage of PTU are you on? 50mg once daily. This is day three since switching from 5 mg Carbimazole daily. Yesterday I was hot and sweaty in the afternoon. I'm sitting here with a towel around me to mop up the sweat today, and a nasty headache lurking. The switch was because of alcohol intolerance whilst taking Carbimazole, and a strange ache in my left side just below the ribs which came and went. Right now I'm thinking not being able to sleep on your left side is a small price to pay for NOT being hyper The ache has gone - but then it came and went... Took an extra half tab (25mg) when I crawled out of bed for dinner this evening. Told doctor I'd try splitting dose into 25mg twice a day if I felt bad today. He trusts me not to do anything too radical with the dosing without checking with him. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2002 Report Share Posted April 22, 2002 Crawford wrote: > > > I'm switching to PTU from 5mg Carbimazole daily, and have gone > > slightly hyper and feel dreadful. > > welcome to the group :-) I've been dealing with this Graves thing a while (Started 1985, diagnosed 1991 grr, subtotal thyroidectomy 1995, hyper again 2000). Just never needed to know about PTU before, last time Carbimazole worked fine. > What dosage of PTU are you on? 50mg once daily. This is day three since switching from 5 mg Carbimazole daily. Yesterday I was hot and sweaty in the afternoon. I'm sitting here with a towel around me to mop up the sweat today, and a nasty headache lurking. The switch was because of alcohol intolerance whilst taking Carbimazole, and a strange ache in my left side just below the ribs which came and went. Right now I'm thinking not being able to sleep on your left side is a small price to pay for NOT being hyper The ache has gone - but then it came and went... Took an extra half tab (25mg) when I crawled out of bed for dinner this evening. Told doctor I'd try splitting dose into 25mg twice a day if I felt bad today. He trusts me not to do anything too radical with the dosing without checking with him. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2002 Report Share Posted April 22, 2002 I switched from 50 mg PTU 3X day to 10 mg. methimazole 2 X a day last October and went REALLY hypo. There was a discussion last week on what dose of PTU is equivalent to methimazole. I wonder if carbimazole is the same as methimazole dose-wise. If so, I don't remember exactly (you should check the archives), but I'm thinking methimazole was 10 times stronger than PTU. With that said, my doc probably should have put me on 15 mg a day instead of 20. How much PTU have you been on? Holly Switching to PTU Hi, I'm switching to PTU from 5mg Carbimazole daily, and have gone slightly hyper and feel dreadful. Really keen to know if anyone else has switched to or from PTU, and if so what drug and what dose they were on before and after the switch, and why they switched. I can't find anything on dose equivalence between PTU and Carbimazole. The doctor did some research but he clearly underestimated, I suspect it is the short life of the PTU that is the problem. Anyway anyone who switched successfully (or otherwise?) please tell me how the doses worked out. I've taken an extra half tab this evening, but I've been sweating buckets on and off all day and could really do with a sanity check on the dosing. Simon Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2002 Report Share Posted April 22, 2002 I switched from 50 mg PTU 3X day to 10 mg. methimazole 2 X a day last October and went REALLY hypo. There was a discussion last week on what dose of PTU is equivalent to methimazole. I wonder if carbimazole is the same as methimazole dose-wise. If so, I don't remember exactly (you should check the archives), but I'm thinking methimazole was 10 times stronger than PTU. With that said, my doc probably should have put me on 15 mg a day instead of 20. How much PTU have you been on? Holly Switching to PTU Hi, I'm switching to PTU from 5mg Carbimazole daily, and have gone slightly hyper and feel dreadful. Really keen to know if anyone else has switched to or from PTU, and if so what drug and what dose they were on before and after the switch, and why they switched. I can't find anything on dose equivalence between PTU and Carbimazole. The doctor did some research but he clearly underestimated, I suspect it is the short life of the PTU that is the problem. Anyway anyone who switched successfully (or otherwise?) please tell me how the doses worked out. I've taken an extra half tab this evening, but I've been sweating buckets on and off all day and could really do with a sanity check on the dosing. Simon Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2002 Report Share Posted April 22, 2002 I switched from 50 mg PTU 3X day to 10 mg. methimazole 2 X a day last October and went REALLY hypo. There was a discussion last week on what dose of PTU is equivalent to methimazole. I wonder if carbimazole is the same as methimazole dose-wise. If so, I don't remember exactly (you should check the archives), but I'm thinking methimazole was 10 times stronger than PTU. With that said, my doc probably should have put me on 15 mg a day instead of 20. How much PTU have you been on? Holly Switching to PTU Hi, I'm switching to PTU from 5mg Carbimazole daily, and have gone slightly hyper and feel dreadful. Really keen to know if anyone else has switched to or from PTU, and if so what drug and what dose they were on before and after the switch, and why they switched. I can't find anything on dose equivalence between PTU and Carbimazole. The doctor did some research but he clearly underestimated, I suspect it is the short life of the PTU that is the problem. Anyway anyone who switched successfully (or otherwise?) please tell me how the doses worked out. I've taken an extra half tab this evening, but I've been sweating buckets on and off all day and could really do with a sanity check on the dosing. Simon Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2002 Report Share Posted April 22, 2002 50 mg a day does not seem like much... and also I thought PTU only lasted for 8 hours at a time. I am on 150 mg a day, a pill every 8 hours, but then I have only been having treatment for a few months, and I am currently hyper (once again). I hope you get your doses sorted Simon. Take care, Katy. Re: Switching to PTU Crawford wrote: > > > I'm switching to PTU from 5mg Carbimazole daily, and have gone > > slightly hyper and feel dreadful. > > welcome to the group :-) I've been dealing with this Graves thing a while (Started 1985, diagnosed 1991 grr, subtotal thyroidectomy 1995, hyper again 2000). Just never needed to know about PTU before, last time Carbimazole worked fine. > What dosage of PTU are you on? 50mg once daily. This is day three since switching from 5 mg Carbimazole daily. Yesterday I was hot and sweaty in the afternoon. I'm sitting here with a towel around me to mop up the sweat today, and a nasty headache lurking. The switch was because of alcohol intolerance whilst taking Carbimazole, and a strange ache in my left side just below the ribs which came and went. Right now I'm thinking not being able to sleep on your left side is a small price to pay for NOT being hyper The ache has gone - but then it came and went... Took an extra half tab (25mg) when I crawled out of bed for dinner this evening. Told doctor I'd try splitting dose into 25mg twice a day if I felt bad today. He trusts me not to do anything too radical with the dosing without checking with him. ------------------------------------- The Graves' list is intended for informational purposes only and is not intended to replace expert medical care. Please consult your doctor before changing or trying new treatments. ---------------------------------------- DISCLAIMER Advertisments placed on this yahoo groups list does not have the endorsement of the listowner. I have no input as to what ads are attached to emails. ---------------------------------------------------------------------------- ---------- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2002 Report Share Posted April 22, 2002 50 mg a day does not seem like much... and also I thought PTU only lasted for 8 hours at a time. I am on 150 mg a day, a pill every 8 hours, but then I have only been having treatment for a few months, and I am currently hyper (once again). I hope you get your doses sorted Simon. Take care, Katy. Re: Switching to PTU Crawford wrote: > > > I'm switching to PTU from 5mg Carbimazole daily, and have gone > > slightly hyper and feel dreadful. > > welcome to the group :-) I've been dealing with this Graves thing a while (Started 1985, diagnosed 1991 grr, subtotal thyroidectomy 1995, hyper again 2000). Just never needed to know about PTU before, last time Carbimazole worked fine. > What dosage of PTU are you on? 50mg once daily. This is day three since switching from 5 mg Carbimazole daily. Yesterday I was hot and sweaty in the afternoon. I'm sitting here with a towel around me to mop up the sweat today, and a nasty headache lurking. The switch was because of alcohol intolerance whilst taking Carbimazole, and a strange ache in my left side just below the ribs which came and went. Right now I'm thinking not being able to sleep on your left side is a small price to pay for NOT being hyper The ache has gone - but then it came and went... Took an extra half tab (25mg) when I crawled out of bed for dinner this evening. Told doctor I'd try splitting dose into 25mg twice a day if I felt bad today. He trusts me not to do anything too radical with the dosing without checking with him. ------------------------------------- The Graves' list is intended for informational purposes only and is not intended to replace expert medical care. Please consult your doctor before changing or trying new treatments. ---------------------------------------- DISCLAIMER Advertisments placed on this yahoo groups list does not have the endorsement of the listowner. I have no input as to what ads are attached to emails. ---------------------------------------------------------------------------- ---------- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2002 Report Share Posted April 22, 2002 Hi Simon, Welcome to the group. What dose of ptu are you currently on? To get the best effect from ptu you need to split your dose into every 8 hours because of the short half life of ptu. The Carbimazole is closer to Tapazole in how it works, this can be taken once or twice a day. PTU needs every 8 hours. When were your labs checked last? Might be a good idea to request they be done now, and adjust your ptu accordingly with your doctor. When I took 75mg of ptu a day, my doctor told me it was essential to take 1/2 tablet every 8 hours for max. benefit, she was right. Take care, Jody _________________________________________________________________ MSN Photos is the easiest way to share and print your photos: http://photos.msn.com/support/worldwide.aspx Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2002 Report Share Posted April 22, 2002 Hi Simon, Welcome to the group. What dose of ptu are you currently on? To get the best effect from ptu you need to split your dose into every 8 hours because of the short half life of ptu. The Carbimazole is closer to Tapazole in how it works, this can be taken once or twice a day. PTU needs every 8 hours. When were your labs checked last? Might be a good idea to request they be done now, and adjust your ptu accordingly with your doctor. When I took 75mg of ptu a day, my doctor told me it was essential to take 1/2 tablet every 8 hours for max. benefit, she was right. Take care, Jody _________________________________________________________________ MSN Photos is the easiest way to share and print your photos: http://photos.msn.com/support/worldwide.aspx Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2002 Report Share Posted April 22, 2002 Hi Simon, Welcome to the group. What dose of ptu are you currently on? To get the best effect from ptu you need to split your dose into every 8 hours because of the short half life of ptu. The Carbimazole is closer to Tapazole in how it works, this can be taken once or twice a day. PTU needs every 8 hours. When were your labs checked last? Might be a good idea to request they be done now, and adjust your ptu accordingly with your doctor. When I took 75mg of ptu a day, my doctor told me it was essential to take 1/2 tablet every 8 hours for max. benefit, she was right. Take care, Jody _________________________________________________________________ MSN Photos is the easiest way to share and print your photos: http://photos.msn.com/support/worldwide.aspx Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2002 Report Share Posted April 22, 2002 Hi Simon, Try breaking your pill into half, then one of the halfs to 1/4. Take the 1/4 in the morning and afternoon, then the half at bed time, just so they are 8 hours apart. Even that little 1/4 does help. Pam L has shared so much in group about how to do this and how much it helped. I took her advice and low and behold it did work. If you are going to take the extra 1/2 tab at night, then split the whole pill in half and take 1/2 every 8 hours. It shouldn't take too long to feel a difference. The big trick with PTU is EVERY 8 HOURS! Good luck, Jody _________________________________________________________________ Send and receive Hotmail on your mobile device: http://mobile.msn.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2002 Report Share Posted April 22, 2002 Hi Simon, Try breaking your pill into half, then one of the halfs to 1/4. Take the 1/4 in the morning and afternoon, then the half at bed time, just so they are 8 hours apart. Even that little 1/4 does help. Pam L has shared so much in group about how to do this and how much it helped. I took her advice and low and behold it did work. If you are going to take the extra 1/2 tab at night, then split the whole pill in half and take 1/2 every 8 hours. It shouldn't take too long to feel a difference. The big trick with PTU is EVERY 8 HOURS! Good luck, Jody _________________________________________________________________ Send and receive Hotmail on your mobile device: http://mobile.msn.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2002 Report Share Posted April 22, 2002 Hi Simon, Try breaking your pill into half, then one of the halfs to 1/4. Take the 1/4 in the morning and afternoon, then the half at bed time, just so they are 8 hours apart. Even that little 1/4 does help. Pam L has shared so much in group about how to do this and how much it helped. I took her advice and low and behold it did work. If you are going to take the extra 1/2 tab at night, then split the whole pill in half and take 1/2 every 8 hours. It shouldn't take too long to feel a difference. The big trick with PTU is EVERY 8 HOURS! Good luck, Jody _________________________________________________________________ Send and receive Hotmail on your mobile device: http://mobile.msn.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2002 Report Share Posted April 22, 2002 > 50mg once daily. This is day three since switching from 5 mg > Carbimazole daily. Others may have already answered, but usually 50mg is a pretty small dose used to just maintain an already euthyroid state... it also needs to be taken 8 hours apart. Even so, with 50mg 2 times a day, you may still get some roller coaster action. Before I went into remission, I was euthyoid on 75mg's a day taken twice a day, so I think 50mg's is really quite small. Val Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2002 Report Share Posted April 22, 2002 > 50mg once daily. This is day three since switching from 5 mg > Carbimazole daily. Others may have already answered, but usually 50mg is a pretty small dose used to just maintain an already euthyroid state... it also needs to be taken 8 hours apart. Even so, with 50mg 2 times a day, you may still get some roller coaster action. Before I went into remission, I was euthyoid on 75mg's a day taken twice a day, so I think 50mg's is really quite small. Val Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2002 Report Share Posted April 22, 2002 > 50mg once daily. This is day three since switching from 5 mg > Carbimazole daily. Others may have already answered, but usually 50mg is a pretty small dose used to just maintain an already euthyroid state... it also needs to be taken 8 hours apart. Even so, with 50mg 2 times a day, you may still get some roller coaster action. Before I went into remission, I was euthyoid on 75mg's a day taken twice a day, so I think 50mg's is really quite small. Val Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2002 Report Share Posted April 22, 2002 " Valkyrie J. Liles " wrote: > > Others may have already answered, but usually 50mg is a pretty small > dose used to just maintain an already euthyroid state... it also > needs to be taken 8 hours apart. Thanks Valkyrie and Everyone, I was euthyroid (possibly slightly hypo, but it varied week to week) on 5mg of Carbimazole, which is the smallest practical dose of Carbimazole (The tablets are small with no scoring to assist cutting). So a low dose of PTU seems not unreasonable. I suspect the need for such a low dose is a direct result of the subtotal thyroidectomy I had a few years back, as in 1992 I was stable on 15mg Carbimazole a day. I think it is the need to spread it out that was underestimated, I did query the 'once a day' dosing with my doctor when it was prescribed as I had seen advice to space it out before, but he sounded confident. Took half a pill this afternoon, and have stopped sweating. Hmm 1/4, 1/4, 1/2 sounds a reasonable next step to try, argh why do they make them in such large doses. I think practical considerations might push me to 1/2 a pill twice a day. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2002 Report Share Posted April 22, 2002 " Valkyrie J. Liles " wrote: > > Others may have already answered, but usually 50mg is a pretty small > dose used to just maintain an already euthyroid state... it also > needs to be taken 8 hours apart. Thanks Valkyrie and Everyone, I was euthyroid (possibly slightly hypo, but it varied week to week) on 5mg of Carbimazole, which is the smallest practical dose of Carbimazole (The tablets are small with no scoring to assist cutting). So a low dose of PTU seems not unreasonable. I suspect the need for such a low dose is a direct result of the subtotal thyroidectomy I had a few years back, as in 1992 I was stable on 15mg Carbimazole a day. I think it is the need to spread it out that was underestimated, I did query the 'once a day' dosing with my doctor when it was prescribed as I had seen advice to space it out before, but he sounded confident. Took half a pill this afternoon, and have stopped sweating. Hmm 1/4, 1/4, 1/2 sounds a reasonable next step to try, argh why do they make them in such large doses. I think practical considerations might push me to 1/2 a pill twice a day. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2002 Report Share Posted April 22, 2002 Hi Simon! Welcome to the group! I do not have Grave's but the love of my life, Joe, does. He had RAI treatment almost two months ago and had been on 20mg Methimazole 1x/day before treatment. He had to switch to PTU as the Mez was giving him hives. He currently is taking 50mg PTU every 8 hours (short life again -- it's strange that you were told once a day) and is generally doing very well on this dose. He's had trouble remembering to take his PTU on time -- sometimes missing up to 2 doses in a row, but he's making a larger commitment to remember as last time he did that -- last week -- he went, well, nuts! As long as he's taking his PTU on time he feels good. I have come to recognize when he's missed a dose (or two!) as his whole persona begins to change. That would put YOU, too, on a roller coaster on a daily basis, one would think, on just one dose per day. I don't think it would be unreasonable for you to contact your doctor and ask if you could take 25mg 3x a day. Or, just do it. 25mg may be too high, but everyone's given you what seems to be the logical reasoning behind your excessive sweating bouts, etc., and if nothing else, it begs a call to you doctor! The important thing is that you feel good! I hope you are here to share with us all when you can! It's great to have you here! Ann Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2002 Report Share Posted April 22, 2002 I switched from PTU to Tapazole. I was taking 750 mg of PTU and am not taking 40 mg Tap. The reason I switched is because I had an allergic reaction to the PTU - I broke out in all all-over-the-body rash. I haven't had any problems on the Tap and my dosage is higher (when you do the conversion). Simon Waters wrote: Hi, I'm switching to PTU from 5mg Carbimazole daily, and have gone slightly hyper and feel dreadful. Really keen to know if anyone else has switched to or from PTU, and if so what drug and what dose they were on before and after the switch, and why they switched. I can't find anything on dose equivalence between PTU and Carbimazole. The doctor did some research but he clearly underestimated, I suspect it is the short life of the PTU that is the problem. Anyway anyone who switched successfully (or otherwise?) please tell me how the doses worked out. I've taken an extra half tab this evening, but I've been sweating buckets on and off all day and could really do with a sanity check on the dosing. Simon Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2002 Report Share Posted April 22, 2002 I switched from PTU to Tapazole. I was taking 750 mg of PTU and am not taking 40 mg Tap. The reason I switched is because I had an allergic reaction to the PTU - I broke out in all all-over-the-body rash. I haven't had any problems on the Tap and my dosage is higher (when you do the conversion). Simon Waters wrote: Hi, I'm switching to PTU from 5mg Carbimazole daily, and have gone slightly hyper and feel dreadful. Really keen to know if anyone else has switched to or from PTU, and if so what drug and what dose they were on before and after the switch, and why they switched. I can't find anything on dose equivalence between PTU and Carbimazole. The doctor did some research but he clearly underestimated, I suspect it is the short life of the PTU that is the problem. Anyway anyone who switched successfully (or otherwise?) please tell me how the doses worked out. I've taken an extra half tab this evening, but I've been sweating buckets on and off all day and could really do with a sanity check on the dosing. Simon Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2002 Report Share Posted April 22, 2002 Sorry Simon, I'm no help here! I am newly diagnosed and on Methimazole I would like to take PTU. I was put on Methimazole when I first went to the Endro and I was thinking " survival " not baby land! Now I know that I don't have to have RAI right off the bat or Surgery so what I'm thinking of doing this Friday is asking Endro about PTU I'm not sure why he put me on the Methimazole is it stronger? Is PTU or Methimazole better? Hmm I will have to make a note of it and ask Endro. I think you should consult your Endro on all this cutting of pills though. Alyssa Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2002 Report Share Posted April 22, 2002 Sorry Simon, I'm no help here! I am newly diagnosed and on Methimazole I would like to take PTU. I was put on Methimazole when I first went to the Endro and I was thinking " survival " not baby land! Now I know that I don't have to have RAI right off the bat or Surgery so what I'm thinking of doing this Friday is asking Endro about PTU I'm not sure why he put me on the Methimazole is it stronger? Is PTU or Methimazole better? Hmm I will have to make a note of it and ask Endro. I think you should consult your Endro on all this cutting of pills though. Alyssa Quote Link to comment Share on other sites More sharing options...
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