Oat Beta Glucan

[Guest guest]

Organization: Sheldon Marketing

cures for cancer

From: Sheldon Marketing <info@...>

Date sent: Sat, 09 Jun 2001 17:46:18 -0700

Send reply to: cures for cancer

Subject: oat beta glucan

> Dear Moonbeam/Sunshine and all,

> Does anyone have any info on oat beta glucan? I need to get started

> taking it right away, and I found a site that states that oat is better

> than yeast? Anyone? in Arizona

Hi ,

there is much less published data on the effects of oat glucan.

It has been shown to be good for lowering cholesterol though.

Nearly all the studies have been done on mushroom or yeast derived beta

glucan.

That guy that says it is better is only giving his personal point of view.

moonbeam

[Guest guest]

Wow, does sound amazing ! !

Thank you for sharing ! !

Hugs DedeThe year's hottest artists on the red carpet at the Grammy Awards. AOL Music takes you there.

[Guest guest]

I thought some of you might be interested in this. Looks like some

pretty amazing stuff! Looks like it would be a great one to include

in our post-explant detox. )

BETA-1,3-D-GLUCAN

BETA-1,3-D-GLUCAN MAY WELL BE THE SINGLE MOST POTENT IMMUNE MODULATOR

TO POTENTIALLY ALLOW YOUR OWN BODY TO RETURN ITSELF TO NORMAL.

IMMUNE ACTIVATORS: ENHANCES IMMUNITY WHERE IT STARTS AT THE

MACROPHAGES.

ANTIOXIDANT: A POTENT INTRACELLULAR FREE-RADICAL SCAVENGER.

TISSUE REGENERATION AND REPAIR: SPEEDS RECOVERY OF DAMAGED TISSUE.

RADIOPROTECTIVE: OFFERS IMMUNE SYSTEM PROTECTION AGAINST RADIATION.

TISSUE REGENERATION AND REPAIR: SPEEDS RECOVERY OF DAMAGED TISSUE.

ADJUVANT EFFECT: ENHANCES EFFECTS OF ANTIBIOTICS, ANT-FUNGAL, ANTI-

VIRAL AND ANTI-PARASITIC SUBSTANCES.

ANTI-NEOPLASTIC EFFECT: MAKES MACROPHAGES RECOGNIZE, ATTACK AND

DESTROY MUTATED CELLS AND COMMUNICATE TO OTHER IMMUNE CELLS FOR AN

ATTACK ON THE INVADERS.

THE PRODUCT CONTAINS BETA-1,3-D-GLUCAN, A UNIQUE INGREDIENT DERIVED

FROM THE CELL WALLS OF BAKERS' YEAST(SACCHAROMYCES CEREVISIAE). ONCE

OUR IMMUNE SYSTEM IS ACTIVATED BY BETA-1,3-D-GLUCAN, THE IMMUNE

SYSTEM CREATES A PERMANENT DEFENSE AGAINST VIRAL, BACTERIAL, FUNGAL,

PARASITIC OR NEOPLASTIC ASSAILANTS. UNLIKE OTHER IMMUNE ENHANCING

SUPPLEMENTS AND PHARMACOLOGICAL DRUGS, BETA-1,3-D-GLUCAN TRIGGERS THE

CELL-MEDIATED IMMUNE RESPONSE SELECTIVELY-IT BEGINS WITH THE

MACROPHAGE CELLS

http://www.vitacost.com/NSI-Organic-Oat-Beta-Glucan-Complex

[Guest guest]

No problemo! )

I found another article that's a little more in-depth. The clinical

studies are amazing! I'm going to start putting some in my oatmeal

for breakfast!

Beta Glucan Articles and Medical Summary

Copyright by A. J. Lanigan

Clinical Applications (conclusions of investigators) Cancer: Numerous

studies report that beta-1, 3-D glucan has anti-tumor and anti-cancer

activity.[1],[2] In one study, intralesional administration of beta-

1, 3-D glucans resulted in rapid tumor shrinkage. [3] In another

study with mice, beta-1, 3-D glucan in conjunction with interferon

gamma (INF-gamma) inhibited both the establishment of tumors and

liver metastasis.[4] In some studies, beta-1, 3-D glucans enhanced

the effects of chemotherapy. In studies on bladder cancer with mice,

administration of cyclophosphamide, in conjunction with beta-1, 3-D

glucans derived from yeast resulted in reduced mortality.[5] In

human patients with advanced gastric or colorectal cancer, the

administration of beta-1, 3-D glucans derived from shiitake

mushrooms, in conjunction with chemotherapy (mitomycin C + 5-

Fluorouracil) resulted in prolonged survival times compared to a

control group receiving identical chemotherapy.[6]

Elevated cholesterol: Beta-glucans appear to be the major cholesterol

lowering agents in oat bran fiber. Studies reveal that soluble

glucans in oat bran can lower total cholesterol and LDL cholesterol

levels in patients with hypercholesterolemia.[7],[8] Similar

cholesterol lowering effects are reported in studies where barley is

the source of beta glucans.[9]

Prevention of infection: 41 patients with multiple trauma (but no

infections) were admitted to a double-blind trial to receive beta-1,

3-D glucan or a placebo. 11 of 20 controls contracted pneumonia vs

only 2 of 21 treated with beta-1, 3-D glucan. Sepsis developed in 35%

of controls vs 9.5% of those treated with glucan; deaths due to

infection and general mortality in controls was 30% and 42.1%

compared to 4.8% and 23.5% in the beta-1, 3-D glucan-treated group.

[10]

Radiation exposure: In animal experiments, therapy with beta-1, 3-D

glucans reportedly enhances recovery after radiation exposure and

results in improvements in the bone marrow, spleen and white blood

count.[11],[12]

Septic shock: Toxins from either external or internal (infections)

sources cause leukocytes to release pro-inflammatory cytokines that

can produce a series of biochemical events that ends in septic

shock. Administration of soluble beta-1, 3/1/6 glucans reduces the

production of pro-inflammatory cytokines, most notably Tumor Necrosis

Factor-alpha (TNF-alpha), which reduced mortality.[13]

Surgery: In mice, treatment with beta-1, 3-D glucans either pre-or

post-surgically reduced the production of nuclear factor-kappa B (NF-

kappa and nuclear factor interleukin 6 (NF-IL6), which increased

long-term survival approximately 40%.[14]

Wound healing: Macrophage activity is known to play a key role in

wound healing from surgery or trauma. In both animal and human

studies, therapy with beta glucan has provided improvements such as

fewer infections, reduced mortality, and stronger tensile strength of

scar tissue.

Glucans are long-chained polysaccharides that only contain glucose as

structural components. Beta-1, 3-D glucans are chains of

polysaccharides (complex glucose molecules), with the six-sided

glucose rings connected at the 1 and 3 positions. Smaller side

chains branch off the 1,3 polysaccharide backbone. The most active

form of beta-1, 3-D glucans are apparently those that contain 1,6

side-chains branching off from the longer beta-1, 3-D glucan

backbone. Sometimes you may see the expression of beta-1, 3-D glucan

as 1, 3/1,6 glucan. Some researchers have suggested that it is the

frequency, location, and length of the side-chains rather than the

backbone of beta glucans that determine their immune system

activity. Another variable found is the existence of single strand

chains, while the backbones of other beta-1, 3-D glucans exist as

double or triple stranded helix chains. Although these compounds

have exciting potential for enhancement of the immune system, it must

be emphasized that this research is in its infancy, and there are

differing opinions on which molecular weight, shape, structure, and

source of beta-1, 3-D glucans provide the greatest therapeutic

benefit.

One of the most common sources of beta-1, 3-D glucans is derived from

the cell walls of baker's yeast (Saccharomyces cerevisiae). However,

some glucans are also extracted from the bran of some grains such as

oats and barley. The beta-1, 3-D glucans from yeast are insoluble

whereas the glucans extracted from grains and mushrooms tend to be

soluble. Other sources include some types of seaweed[15], and

various species of mushrooms such as Reishi, Shiitake, and Maitake.

[16] Beta-1, 3-D glucans are being referred to as biological

response modifiers (BRMs) because of their ability to potentiate

(making ready) the immune system.[17] However, it should be noted

that the activity of beta-1, 3-D glucans is different from agents

that stimulate the immune system.

Agents that stimulate the immune system can push the system to over-

reactivity, and hence are contraindicated in individuals with

autoimmune diseases. Beta-1, 3-D glucans seem to make the immune

system work better without becoming overactive. They accomplish this

by potentiating the macrophages, which are immune system cells whose

function is to trap and destroy foreign substances in our bodies such

as bacteria, virus, fungi, and parasites.[18] In addition to

enhancing the activity of macrophages, beta-1, 3-D glucans also

reportedly lower elevated LDL cholesterol, aid in wound healing, help

prevent infections, and help in the prevention and treatment of

cancer.

Functions in the Body Macrophage activity: Beta-1, 3-D glucans

improve the body's immune system defense against foreign invaders by

enhancing the ability of macrophages to respond to and fight a wide

range of toxic substances such as bacteria, viruses, fungi, and

parasites.[19] Immune system activity: Beta-1, 3-D glucans also

increase the production of cytokines such as tumor necrosis factor

[20] and certain subsets of T-lymphocytes.[21] Although this research

has been done in animals, the results suggest that beta-1, 3-D

glucans enhance both non-specific host defense and cellular immune

response. Lowers elevated cholesterol levels: Studies have

reported that the beta glucans, found in grains such as oats and

barley, are effective at lowering elevated total and LDL cholesterol

levels.[22],[23] Beta-1, 3-D glucans do not occur naturally in

humans, hence no deficiency condition exists.

Absorption: For best results, beta-1, 3-D glucans should be taken on

an empty stomach. Enterocytes reportedly facilitate the

transportation of beta-1, 3-D glucans and similar compounds across

the intestinal cell wall into the lymph where they begin to interact

with macrophages to activate immune function.[24] Radiolabeled

studies have verified that both small and large fragments of beta

glucans are found in the serum, which indicates they are absorbed

from the intestinal tract.[25]

Dietary Sources: Although beta-1, 3-D glucans occurs in bakers yeast,

grains such as oats and barley, and several types of mushrooms, they

are not readily useable in their unpurified natural state. The

indigestible cell walls of these substances must be processed in

order to free up the beta-1, 3-D glucans and make them available for

useful purposes. [26]