Phthalates: FDA research back to 1995 they knew this was making us sick and did nothing

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Phthalates: FDA

research back to 1995 they knew this was making us sick and did nothing Description: There is concern over the

potential exposure in the general population- especially during fetal or early postnatal

development- to estrogeniclike compounds -bisphenol A, nonyl phenol,

phthalates- present in polymeric medical devices. In the body, these chemicals

can emulate estrogen and trigger unwanted biological effects. Development of a

physiologically-based pharmacokinetic model (PBPK) would allow a more

quantitative assessment of the potential risks associated with low dose

exposure of endocrine disruptors leached from medical devices.

Description: Some components of

materials; used in medical devices have been shown to have estrogenic

properties. However, no systematic survey of these materials for estrogenic

activity has been undertaken. We are beginning to survey the classes of

rnaterials found in medical devices f or estrogenic activity using a cell culture

screen, confirmed when necessary by the mouse uterotrophic assay, when deemed

suitable to the Center's needs, by a molecular gene activation assay Endocrine Disruptor

Research Project Level Inventory Breakdown by ... Endocrine Disruptor Knowledge Base · Development of a PBPK model to predict

exposure to xenoestrogens leached from polymeric medical devices ...

http://oaspub.epa.gov/gedri/pack_edri.SponsorByFocus?p_Sponsor=USFDA - 7k - similar pages Research Project Level Inventory by Agency Involvement

Agency: USFDA Primary

Focus Human:

(9)

Endocrine

Disruptor Knowledge Base Development

of a PBPK model to predict exposure to xenoestrogens leached from

polymeric medical devices BIOLOGICAL

RESPONSES TO PARTICULATE MATERIAL MEASUREMENT

OF ESTROGENIC EFFECTS OF MATERIALS ASSOCIATED WITH MEDICAL

DEVICES:DEVELOPMENT OF A MOLECULAR ASSAY FOR ESTROGENIC EFFECTS The

effects of dietary genistein on the growth of chemically-induced mammary

tumors in ovariectomized and intact rats DETERMINATION

OF ANTI-THYROID PROPERTIES OF DIETARY GENISTEIN MEASUREMENT

OF ESTROGENIC EFFECTS OF MATERIALS ASSOCIATED WITH MEDICAL DEVICES VALIDATION

OF AN IN VITRO RAT UTERINE ESTROGEN RECEPTOR BINDING ASSAY TO GENERATE

RBA DATA FOR USE IN 3D-QSAR MODELING OF POTENTIAL ENDOCRINE DISRUPTORS

Evaluation

of the genotoxic potential of genistein in human lymphoblastoid cells

Ecology:

(0) Exposure:

(6)

Market

basket analysis of dairy products and commercial fish for dioxins and

furans Determination

of the endocrine disruptors dibutylphthalate and butyl benzyl phthlate

migrating to foods from food packaging. DNA

Addutcts of Tamoxifen Annual

market basket analysis of the United States Food Supply for pesticides,

elemental contaminants and nutrients and industrial contaminants DETERMINATION

OF THE ENDOCRINE DISRUPTEORS, BISPHENOL-A AND NONYL PHENOL, MIGRATING TO

FOODS AS THE RESULT OF THEIR USE AS APPROVED INDIRECT ADDITIVE CHEMICALS IN

FOOD PACKAGING Development

of in vitro human cell culture systems to screen compounds expected to

have estrogenic or anti-estrogenic activity.

Secondary

Focus Human:

(4)

Determination

of the endocrine disruptors dibutylphthalate and butyl benzyl phthlate

migrating to foods from food packaging. Development

of a PBPK model to predict exposure to xenoestrogens leached from

polymeric medical devices DETERMINATION

OF THE ENDOCRINE DISRUPTEORS, BISPHENOL-A AND NONYL PHENOL, MIGRATING TO

FOODS AS THE RESULT OF THEIR USE AS APPROVED INDIRECT ADDITIVE CHEMICALS

IN FOOD PACKAGING Development

of in vitro human cell culture systems to screen compounds expected to

have estrogenic or anti-estrogenic activity.

Ecology:

(2)

VALIDATION

OF AN IN VITRO RAT UTERINE ESTROGEN RECEPTOR BINDING ASSAY TO GENERATE

RBA DATA FOR USE IN 3D-QSAR MODELING OF POTENTIAL ENDOCRINE DISRUPTORS

Endocrine

Disruptor Knowledge Base

Exposure

(5)

MEASUREMENT

OF ESTROGENIC EFFECTS OF MATERIALS ASSOCIATED WITH MEDICAL DEVICES BIOLOGICAL

RESPONSES TO PARTICULATE MATERIAL MEASUREMENT

OF ESTROGENIC EFFECTS OF MATERIALS ASSOCIATED WITH MEDICAL

DEVICES:DEVELOPMENT OF A MOLECULAR ASSAY FOR ESTROGENIC EFFECTS The

effects of dietary genistein on the growth of chemically-induced mammary

tumors in ovariectomized and intact rats DETERMINATION

OF ANTI-THYROID PROPERTIES OF DIETARY GENISTEIN

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