Silicone in ALL capsules, and found in Joint Synovium

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: Plast Reconstr Surg. 1995 Mar;95(3):513-9.Links

Electron probe microanalysis of silicon and the role of the macrophage in proximal (capsule) and distant sites in augmentation mammaplasty patients.

Greene WB, Raso DS, Walsh LG, Harley RA, Silver RM.

Department of Pathology and Laboratory Medicine, Medical University of South Carolina, ton.

Electron probe x-ray microanalysis was used to locate silicon (Si) within macrophages from 12 women who had previously undergone polymer prosthesis augmentation or reconstruction. Silicon was identified within macrophages and extracellularly in all fibrous breast capsules. In four women with arthritic joint pain and one woman with sclerodermatous skin lesions, silicon also was identified within macrophages residing in joint synovium and skin, respectively. It is suggested that the silicon-laden macrophages observed in the remote lesions may have accumulated silicon from other macrophages that had previously resided in the connective-tissue capsule around the silicone breast implants.

PMID: 7870776 [PubMed - indexed for MEDLINE]

Electron probe microanalysis of silicon and the ro...[Plast Reconstr Surg. 1995] - PubMed Result

1: J Am Acad Dermatol. 1996 Jul;35(1):32-6. Links

Silicone deposition in reconstruction scars of women with silicone breast implants.

Raso DS, Greene WB, Harley RA, Maize JC.

Department of Pathology and Laboratory Medicine, Medical University of South Carolina, ton 29425, USA.

BACKGROUND: The possible association of silicone breast implants and disease is a subject of continuous debate and concern. OBJECTIVE: Our purpose was to examine microscopically and ultrastructurally the periprosthetic fibrous capsules and reconstruction scars of women with silicone breast implants. METHODS: Representative samples from the periprosthetic capsules and reconstruction scars from six women with silicone breast implants were examined by a variety of light microscopy techniques, transmission electron microscopy, and electron probe microanalysis. RESULTS: Silicone globules of various sizes were identified in** EVERY ** periprosthetic capsule and reconstruction scar. CONCLUSION: Extrusion and seeding of the incision tract during surgery most likely accounts for the presence of silicone in the reconstruction scar specimens. This observation suggests that the identification of silicone in the reconstruction scars of women with silicone breast implants does not necessarily implicate rupture of the silicone breast implant with systemic dissemination of silicone gel.

PMID: 8682960 [PubMed - indexed for MEDLINE]

Silicone deposition in reconstruction scars of wom...[J Am Acad Dermatol. 1996] - PubMed Result

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